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Greater osseointegration potential with nanostructured surfaces on TiZsr : Accelerated vs. real‐time ageing

Stavropoulos, Andreas ; Sandgren, Rebecca LU ; Bellon, Benjamin ; Sculean, Anton and Pippenger, Benjamin E. (2021) In Materials 14(7).
Abstract

Surface chemistry and nanotopography of dental implants can have a substantial impact on osseointegration. The aim of this investigation was to evaluate the effects of surface chemistry and nanotopography on the osseointegration of titanium‐zirconium (TiZr; Roxolid®) discs, using a biomechanical pull‐out model in rabbits. Two discs each were placed in both the right and left tibiae of 16 rabbits. Five groups of sandblasted acid etched (SLA) discs were tested: (1) hydrophobic without nanostructures (dry/micro) (n = 13); (2) hydrophobic with nanostructures, accelerated aged (dry/nano/AA) (n = 12); (3) hydrophilic without nanostructures (wet/micro) (n = 13); (4) hydrophilic with nanostructures, accelerated aged (wet/nano/AA; SLActive®) (n... (More)

Surface chemistry and nanotopography of dental implants can have a substantial impact on osseointegration. The aim of this investigation was to evaluate the effects of surface chemistry and nanotopography on the osseointegration of titanium‐zirconium (TiZr; Roxolid®) discs, using a biomechanical pull‐out model in rabbits. Two discs each were placed in both the right and left tibiae of 16 rabbits. Five groups of sandblasted acid etched (SLA) discs were tested: (1) hydrophobic without nanostructures (dry/micro) (n = 13); (2) hydrophobic with nanostructures, accelerated aged (dry/nano/AA) (n = 12); (3) hydrophilic without nanostructures (wet/micro) (n = 13); (4) hydrophilic with nanostructures, accelerated aged (wet/nano/AA; SLActive®) (n = 13); (5) hydrophilic with nanostructures, real‐time aged (wet/nano/RTA). The animals were sacrificed after four weeks and the biomechanical pull‐out force required to remove the discs was evaluated. Adjusted mean pullout force was greatest for group wet/nano/RTA (64.5 ± 17.7 N) and lowest for group dry/micro (33.8 ± 10.7 N). Multivariate mixed model analysis showed that the pull‐out force was significantly greater for all other disc types compared to the dry/micro group. Surface chemistry and topography both had a significant effect on pull‐out force (p < 0.0001 for both), but the effect of the interaction between chemistry and topography was not significant (p = 0.1056). The introduction of nanostructures on the TiZr surface significantly increases osseointegration. The introduction of hydrophilicity to the TiZr implant surface significantly increases the capacity for osseointegration, irrespective of the presence or absence of nanotopography.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hydrophilicity, Nanostructured materials, Osseointegration, Rabbits, Roxolid, SLA, SLActive
in
Materials
volume
14
issue
7
article number
1678
publisher
MDPI AG
external identifiers
  • pmid:33805477
  • scopus:85103953700
ISSN
1996-1944
DOI
10.3390/ma14071678
language
English
LU publication?
yes
id
03438cd9-8ae8-45a8-b1bc-d6cc15406537
date added to LUP
2021-04-20 12:47:06
date last changed
2025-03-09 11:53:51
@article{03438cd9-8ae8-45a8-b1bc-d6cc15406537,
  abstract     = {{<p>Surface chemistry and nanotopography of dental implants can have a substantial impact on osseointegration. The aim of this investigation was to evaluate the effects of surface chemistry and nanotopography on the osseointegration of titanium‐zirconium (TiZr; Roxolid®) discs, using a biomechanical pull‐out model in rabbits. Two discs each were placed in both the right and left tibiae of 16 rabbits. Five groups of sandblasted acid etched (SLA) discs were tested: (1) hydrophobic without nanostructures (dry/micro) (n = 13); (2) hydrophobic with nanostructures, accelerated aged (dry/nano/AA) (n = 12); (3) hydrophilic without nanostructures (wet/micro) (n = 13); (4) hydrophilic with nanostructures, accelerated aged (wet/nano/AA; SLActive®) (n = 13); (5) hydrophilic with nanostructures, real‐time aged (wet/nano/RTA). The animals were sacrificed after four weeks and the biomechanical pull‐out force required to remove the discs was evaluated. Adjusted mean pullout force was greatest for group wet/nano/RTA (64.5 ± 17.7 N) and lowest for group dry/micro (33.8 ± 10.7 N). Multivariate mixed model analysis showed that the pull‐out force was significantly greater for all other disc types compared to the dry/micro group. Surface chemistry and topography both had a significant effect on pull‐out force (p &lt; 0.0001 for both), but the effect of the interaction between chemistry and topography was not significant (p = 0.1056). The introduction of nanostructures on the TiZr surface significantly increases osseointegration. The introduction of hydrophilicity to the TiZr implant surface significantly increases the capacity for osseointegration, irrespective of the presence or absence of nanotopography.</p>}},
  author       = {{Stavropoulos, Andreas and Sandgren, Rebecca and Bellon, Benjamin and Sculean, Anton and Pippenger, Benjamin E.}},
  issn         = {{1996-1944}},
  keywords     = {{Hydrophilicity; Nanostructured materials; Osseointegration; Rabbits; Roxolid; SLA; SLActive}},
  language     = {{eng}},
  number       = {{7}},
  publisher    = {{MDPI AG}},
  series       = {{Materials}},
  title        = {{Greater osseointegration potential with nanostructured surfaces on TiZsr : Accelerated vs. real‐time ageing}},
  url          = {{http://dx.doi.org/10.3390/ma14071678}},
  doi          = {{10.3390/ma14071678}},
  volume       = {{14}},
  year         = {{2021}},
}