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Comparison of elicitation potential of chloroatranol and atranol - 2 allergens in oak moss absolute

Johansen, JD; Bernard, G; Gimenez-Arnau, E; Lepoittevin, JP; Bruze, Magnus LU and Andersen, KE (2006) In Contact Dermatitis 54(4). p.192-195
Abstract
Chloroatranol and atranol are degradation products of chloroatranorin and atranorin, respectively, and have recently been identified as important contact allergens in the natural fragrance extract, oak moss absolute. Oak moss absolute is widely used in perfumery and is the cause of many cases of fragrance allergic contact dermatitis. Chloroatranol elicits reactions at very low levels of exposure. In oak moss absolute, chloroatranol and atranol are present together and both may contribute to the allergenicity and eliciting capacity of the natural extract. In this study, 10 eczema patients with known sensitization to chloroatranol and oak moss absolute were tested simultaneously to a serial dilution of chloroatranol and atranol in ethanol,... (More)
Chloroatranol and atranol are degradation products of chloroatranorin and atranorin, respectively, and have recently been identified as important contact allergens in the natural fragrance extract, oak moss absolute. Oak moss absolute is widely used in perfumery and is the cause of many cases of fragrance allergic contact dermatitis. Chloroatranol elicits reactions at very low levels of exposure. In oak moss absolute, chloroatranol and atranol are present together and both may contribute to the allergenicity and eliciting capacity of the natural extract. In this study, 10 eczema patients with known sensitization to chloroatranol and oak moss absolute were tested simultaneously to a serial dilution of chloroatranol and atranol in ethanol, in equimolar concentrations (0.0034-1072 mu M). Dose-response curves were estimated and analysed by logistic regression. The estimated difference in elicitation potency of chloroatranol relative to atranol based on testing with equimolar concentrations was 217% (95% confidence interval 116-409%). Both substances elicited reactions at very low levels of exposure. It is concluded that the differences in elicitation capacity between the 2 substances are counterbalanced by exposure being greater to atranol than to chloroatranol and that both substances contribute to the clinical problems seen in oak moss absolute-sensitized individuals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
oak moss absolute, relative, potency, natural extracts, lichens, elicitation, dose-response relationships, contact allergy, atranol, chloroatranol
in
Contact Dermatitis
volume
54
issue
4
pages
192 - 195
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:16650093
  • wos:000237195200003
  • scopus:33645718721
ISSN
0105-1873
DOI
10.1111/j.0105-1873.2006.00814.x
language
English
LU publication?
yes
id
03579762-05b7-4670-acd2-d47f05270f7c (old id 693291)
date added to LUP
2008-01-05 13:45:03
date last changed
2019-05-14 02:08:43
@article{03579762-05b7-4670-acd2-d47f05270f7c,
  abstract     = {Chloroatranol and atranol are degradation products of chloroatranorin and atranorin, respectively, and have recently been identified as important contact allergens in the natural fragrance extract, oak moss absolute. Oak moss absolute is widely used in perfumery and is the cause of many cases of fragrance allergic contact dermatitis. Chloroatranol elicits reactions at very low levels of exposure. In oak moss absolute, chloroatranol and atranol are present together and both may contribute to the allergenicity and eliciting capacity of the natural extract. In this study, 10 eczema patients with known sensitization to chloroatranol and oak moss absolute were tested simultaneously to a serial dilution of chloroatranol and atranol in ethanol, in equimolar concentrations (0.0034-1072 mu M). Dose-response curves were estimated and analysed by logistic regression. The estimated difference in elicitation potency of chloroatranol relative to atranol based on testing with equimolar concentrations was 217% (95% confidence interval 116-409%). Both substances elicited reactions at very low levels of exposure. It is concluded that the differences in elicitation capacity between the 2 substances are counterbalanced by exposure being greater to atranol than to chloroatranol and that both substances contribute to the clinical problems seen in oak moss absolute-sensitized individuals.},
  author       = {Johansen, JD and Bernard, G and Gimenez-Arnau, E and Lepoittevin, JP and Bruze, Magnus and Andersen, KE},
  issn         = {0105-1873},
  keyword      = {oak moss absolute,relative,potency,natural extracts,lichens,elicitation,dose-response relationships,contact allergy,atranol,chloroatranol},
  language     = {eng},
  number       = {4},
  pages        = {192--195},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Comparison of elicitation potential of chloroatranol and atranol - 2 allergens in oak moss absolute},
  url          = {http://dx.doi.org/10.1111/j.0105-1873.2006.00814.x},
  volume       = {54},
  year         = {2006},
}