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The nasal mucosa contains a large diversity of human papillomavirus from the Beta- and Gammapapillomavirus genera.

Forslund, Ola LU ; Johansson, Hanna K LU ; Madsen, Klaus Gregaard and Kofoed, Kristian (2013) In Journal of Infectious Diseases 208(8). p.1335-1341
Abstract
Background. Human papillomavirus (HPV) types from the Beta- and Gammapapillomavirus genera are common at cutaneous sites. The aim of this study was to analyze the prevalence of these HPV types in oral and nasal samples.Methods. Nasal and oral samples were taken from 312 volunteers of Danish health-care staff (240 women and 72 males, with mean age of 42 years). Of these 311 oral and 304 nasal samples were eligible for HPV DNA analysis.HPV types were detected by the use of PCR with MGP- and FAP-primers and identified by Luminex (MGP), and direct sequencing or cloning prior to sequencing (FAP).Results. HPV DNA was detected in 6% of the oral samples and 50% of the nasal samples. A large diversity of 75 HPV types/putative HPV types was... (More)
Background. Human papillomavirus (HPV) types from the Beta- and Gammapapillomavirus genera are common at cutaneous sites. The aim of this study was to analyze the prevalence of these HPV types in oral and nasal samples.Methods. Nasal and oral samples were taken from 312 volunteers of Danish health-care staff (240 women and 72 males, with mean age of 42 years). Of these 311 oral and 304 nasal samples were eligible for HPV DNA analysis.HPV types were detected by the use of PCR with MGP- and FAP-primers and identified by Luminex (MGP), and direct sequencing or cloning prior to sequencing (FAP).Results. HPV DNA was detected in 6% of the oral samples and 50% of the nasal samples. A large diversity of 75 HPV types/putative HPV types was identified. HPV types within genus Alpha-, Beta- and Gammapapillomaviruses were detected in 3%, 31%, and 23% of the nasal samples, respectively. A putative subtype of HPV76, originally isolated from a feline oral SCC, was detected in seven nasal samples.Conclusion. A large spectrum of HPV types from Beta- and Gammapapillomavirus have tropism for the nasal mucosa. The implication of the relatively high prevalence of these viruses in the nasal mucosa is unknown. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
208
issue
8
pages
1335 - 1341
publisher
Oxford University Press
external identifiers
  • wos:000324832800019
  • pmid:23878325
  • scopus:84885073133
ISSN
1537-6613
DOI
10.1093/infdis/jit326
language
English
LU publication?
yes
id
03bd2c5c-6459-4ec4-8916-55a78529b3e7 (old id 3955656)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23878325?dopt=Abstract
date added to LUP
2013-08-02 14:14:10
date last changed
2018-11-21 19:50:54
@article{03bd2c5c-6459-4ec4-8916-55a78529b3e7,
  abstract     = {Background. Human papillomavirus (HPV) types from the Beta- and Gammapapillomavirus genera are common at cutaneous sites. The aim of this study was to analyze the prevalence of these HPV types in oral and nasal samples.Methods. Nasal and oral samples were taken from 312 volunteers of Danish health-care staff (240 women and 72 males, with mean age of 42 years). Of these 311 oral and 304 nasal samples were eligible for HPV DNA analysis.HPV types were detected by the use of PCR with MGP- and FAP-primers and identified by Luminex (MGP), and direct sequencing or cloning prior to sequencing (FAP).Results. HPV DNA was detected in 6% of the oral samples and 50% of the nasal samples. A large diversity of 75 HPV types/putative HPV types was identified. HPV types within genus Alpha-, Beta- and Gammapapillomaviruses were detected in 3%, 31%, and 23% of the nasal samples, respectively. A putative subtype of HPV76, originally isolated from a feline oral SCC, was detected in seven nasal samples.Conclusion. A large spectrum of HPV types from Beta- and Gammapapillomavirus have tropism for the nasal mucosa. The implication of the relatively high prevalence of these viruses in the nasal mucosa is unknown.},
  author       = {Forslund, Ola and Johansson, Hanna K and Madsen, Klaus Gregaard and Kofoed, Kristian},
  issn         = {1537-6613},
  language     = {eng},
  number       = {8},
  pages        = {1335--1341},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {The nasal mucosa contains a large diversity of human papillomavirus from the Beta- and Gammapapillomavirus genera.},
  url          = {http://dx.doi.org/10.1093/infdis/jit326},
  volume       = {208},
  year         = {2013},
}