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The Role of Mutation Bias in Adaptive Evolution

Svensson, Erik I. LU and Berger, David (2019) In Trends in Ecology and Evolution 34(5). p.422-434
Abstract

Mutational input is the ultimate source of genetic variation, but mutations are not thought to affect the direction of adaptive evolution. Recently, critics of standard evolutionary theory have questioned the random and non-directional nature of mutations, claiming that the mutational process can be adaptive in its own right. We discuss here mutation bias in adaptive evolution. We find little support for mutation bias as an independent force in adaptive evolution, although it can interact with selection under conditions of small population size and when standing genetic variation is limited, entirely consistent with standard evolutionary theory. We further emphasize that natural selection can shape the phenotypic effects of mutations,... (More)

Mutational input is the ultimate source of genetic variation, but mutations are not thought to affect the direction of adaptive evolution. Recently, critics of standard evolutionary theory have questioned the random and non-directional nature of mutations, claiming that the mutational process can be adaptive in its own right. We discuss here mutation bias in adaptive evolution. We find little support for mutation bias as an independent force in adaptive evolution, although it can interact with selection under conditions of small population size and when standing genetic variation is limited, entirely consistent with standard evolutionary theory. We further emphasize that natural selection can shape the phenotypic effects of mutations, giving the false impression that directed mutations are driving adaptive evolution.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Ecology and Evolution
volume
34
issue
5
pages
422 - 434
publisher
Elsevier
external identifiers
  • pmid:31003616
  • scopus:85062185909
ISSN
0169-5347
DOI
10.1016/j.tree.2019.01.015
language
English
LU publication?
yes
id
03e95fc7-4899-4a40-95f2-bee89c7d749a
date added to LUP
2019-03-11 13:37:05
date last changed
2020-04-02 02:22:50
@article{03e95fc7-4899-4a40-95f2-bee89c7d749a,
  abstract     = {<p>Mutational input is the ultimate source of genetic variation, but mutations are not thought to affect the direction of adaptive evolution. Recently, critics of standard evolutionary theory have questioned the random and non-directional nature of mutations, claiming that the mutational process can be adaptive in its own right. We discuss here mutation bias in adaptive evolution. We find little support for mutation bias as an independent force in adaptive evolution, although it can interact with selection under conditions of small population size and when standing genetic variation is limited, entirely consistent with standard evolutionary theory. We further emphasize that natural selection can shape the phenotypic effects of mutations, giving the false impression that directed mutations are driving adaptive evolution.</p>},
  author       = {Svensson, Erik I. and Berger, David},
  issn         = {0169-5347},
  language     = {eng},
  number       = {5},
  pages        = {422--434},
  publisher    = {Elsevier},
  series       = {Trends in Ecology and Evolution},
  title        = {The Role of Mutation Bias in Adaptive Evolution},
  url          = {http://dx.doi.org/10.1016/j.tree.2019.01.015},
  doi          = {10.1016/j.tree.2019.01.015},
  volume       = {34},
  year         = {2019},
}