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Five homologous repeats of the protein G-related protein MIG cooperate in binding to goat immunoglobulin G

Vasi, J ; Svensson, J ; Frick, Inga-Maria LU and Muller, H P (1999) In Infection and Immunity 67(1). p.413-416
Abstract
Protein MIG, from Streptococcus dysgalactiae, binds alpha2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000- fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
67
issue
1
pages
413 - 416
publisher
American Society for Microbiology
external identifiers
  • pmid:9864244
  • scopus:0032918534
ISSN
1098-5522
language
English
LU publication?
yes
id
040dc67f-993a-4005-ab3b-7626ef762628 (old id 1114651)
alternative location
http://iai.highwire.org/cgi/content/full/67/1/413
date added to LUP
2016-04-01 12:04:39
date last changed
2025-10-14 10:41:58
@article{040dc67f-993a-4005-ab3b-7626ef762628,
  abstract     = {{Protein MIG, from Streptococcus dysgalactiae, binds alpha2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000- fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.}},
  author       = {{Vasi, J and Svensson, J and Frick, Inga-Maria and Muller, H P}},
  issn         = {{1098-5522}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{413--416}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Infection and Immunity}},
  title        = {{Five homologous repeats of the protein G-related protein MIG cooperate in binding to goat immunoglobulin G}},
  url          = {{http://iai.highwire.org/cgi/content/full/67/1/413}},
  volume       = {{67}},
  year         = {{1999}},
}