BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
(1997) In Genes, Chromosomes and Cancer 20(3). p.299-304- Abstract
- A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112562
- author
- Andreasson, Patrik ; Johansson, Bertil LU ; Carlsson, Magnus ; Jarlsfelt, Ingvar ; Fioretos, Thoas LU ; Mitelman, Felix LU and Höglund, Mattias LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genes, Chromosomes and Cancer
- volume
- 20
- issue
- 3
- pages
- 299 - 304
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:9365838
- scopus:0030780203
- ISSN
- 1045-2257
- DOI
- 10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K
- language
- English
- LU publication?
- yes
- id
- 0413314c-840e-4260-8f7f-d62a565b12d8 (old id 1112562)
- date added to LUP
- 2016-04-01 12:01:04
- date last changed
- 2022-04-21 01:09:06
@article{0413314c-840e-4260-8f7f-d62a565b12d8, abstract = {{A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.}}, author = {{Andreasson, Patrik and Johansson, Bertil and Carlsson, Magnus and Jarlsfelt, Ingvar and Fioretos, Thoas and Mitelman, Felix and Höglund, Mattias}}, issn = {{1045-2257}}, language = {{eng}}, number = {{3}}, pages = {{299--304}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Genes, Chromosomes and Cancer}}, title = {{BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion}}, url = {{http://dx.doi.org/10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K}}, doi = {{10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K}}, volume = {{20}}, year = {{1997}}, }