Post-covid medical complaints following infection with SARS-CoV-2 Omicron vs Delta variants
Magnusson, Karin LU ; Kristoffersen, Doris Tove ; Dell’isola, Andrea LU ; Kiadaliri, Ali LU
; Turkiewicz, Aleksandra
LU
; Runhaar, Jos
; Bierma-Zeinstra, Sita
; Englund, Martin
LU
; Magnus, Per Minor
and Kinge, Jonas Minet
(2022)
In Nature Communications
13(1).
- Abstract
- The SARS-CoV-2 Omicron (B.1.1.529) variant has been associated with less
severe acute disease, however, concerns remain as to whether long-term
complaints persist to a similar extent as for earlier variants. Studying 1 323 145
persons aged 18-70 years living in Norway with and without SARS-CoV-2
infection in a prospective cohort study, we found that individuals infected with
Omicron had a similar risk of post-covid complaints (fatigue, cough, heart
palpitations, shortness of breath and anxiety/depression) as individuals
infected with Delta (B.1.617.2), from 14 to up to 126 days after testing positive,
both in the acute (14 to 29 days), sub-acute (30 to 89 days) and chronic post-
covid (≥90 days) phases.... (More) - The SARS-CoV-2 Omicron (B.1.1.529) variant has been associated with less
severe acute disease, however, concerns remain as to whether long-term
complaints persist to a similar extent as for earlier variants. Studying 1 323 145
persons aged 18-70 years living in Norway with and without SARS-CoV-2
infection in a prospective cohort study, we found that individuals infected with
Omicron had a similar risk of post-covid complaints (fatigue, cough, heart
palpitations, shortness of breath and anxiety/depression) as individuals
infected with Delta (B.1.617.2), from 14 to up to 126 days after testing positive,
both in the acute (14 to 29 days), sub-acute (30 to 89 days) and chronic post-
covid (≥90 days) phases. However, at ≥90 days after testing positive, indivi-
duals infected with Omicron had a lower risk of having any complaint (43 (95%
CI = 14 to 72) fewer per 10,000), as well as a lower risk of musculoskeletal pain
(23 (95%CI = 2-43) fewer per 10,000) than individuals infected with Delta. Our
findings suggest that the acute and sub-acute burden of post-covid complaints
on health services is similar for Omicron and Delta. The chronic burden may be
lower for Omicron vs Delta when considering musculoskeletal pain, but not
when considering other typical post-covid complaints. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/0428eb80-56ae-43fc-93b4-f0e067e14c95
- author
- Magnusson, Karin
LU
; Kristoffersen, Doris Tove
; Dell’isola, Andrea
LU
; Kiadaliri, Ali
LU
; Turkiewicz, Aleksandra
LU
; Runhaar, Jos
; Bierma-Zeinstra, Sita
; Englund, Martin
LU
; Magnus, Per Minor
and Kinge, Jonas Minet
- organization
- publishing date
- 2022-11-30
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Rehabilitation, SARS-CoV-2, Viral infection
- in
- Nature Communications
- volume
- 13
- issue
- 1
- article number
- 7363
- pages
- 9 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85143110142
- pmid:36450749
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-022-35240-2
- language
- English
- LU publication?
- yes
- id
- 0428eb80-56ae-43fc-93b4-f0e067e14c95
- date added to LUP
- 2022-11-30 16:37:27
- date last changed
- 2025-04-04 15:02:23
@article{0428eb80-56ae-43fc-93b4-f0e067e14c95,
abstract = {{The SARS-CoV-2 Omicron (B.1.1.529) variant has been associated with less<br/>severe acute disease, however, concerns remain as to whether long-term<br/>complaints persist to a similar extent as for earlier variants. Studying 1 323 145<br/>persons aged 18-70 years living in Norway with and without SARS-CoV-2<br/>infection in a prospective cohort study, we found that individuals infected with<br/>Omicron had a similar risk of post-covid complaints (fatigue, cough, heart<br/>palpitations, shortness of breath and anxiety/depression) as individuals<br/>infected with Delta (B.1.617.2), from 14 to up to 126 days after testing positive,<br/>both in the acute (14 to 29 days), sub-acute (30 to 89 days) and chronic post-<br/>covid (≥90 days) phases. However, at ≥90 days after testing positive, indivi-<br/>duals infected with Omicron had a lower risk of having any complaint (43 (95%<br/>CI = 14 to 72) fewer per 10,000), as well as a lower risk of musculoskeletal pain<br/>(23 (95%CI = 2-43) fewer per 10,000) than individuals infected with Delta. Our<br/>findings suggest that the acute and sub-acute burden of post-covid complaints<br/>on health services is similar for Omicron and Delta. The chronic burden may be<br/>lower for Omicron vs Delta when considering musculoskeletal pain, but not<br/>when considering other typical post-covid complaints.}},
author = {{Magnusson, Karin and Kristoffersen, Doris Tove and Dell’isola, Andrea and Kiadaliri, Ali and Turkiewicz, Aleksandra and Runhaar, Jos and Bierma-Zeinstra, Sita and Englund, Martin and Magnus, Per Minor and Kinge, Jonas Minet}},
issn = {{2041-1723}},
keywords = {{Rehabilitation; SARS-CoV-2; Viral infection}},
language = {{eng}},
month = {{11}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{Post-covid medical complaints following infection with SARS-CoV-2 Omicron vs Delta variants}},
url = {{http://dx.doi.org/10.1038/s41467-022-35240-2}},
doi = {{10.1038/s41467-022-35240-2}},
volume = {{13}},
year = {{2022}},
}