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Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline : Findings from the European Male Ageing Study

Overman, Margot J.; Pendleton, Neil; O'Neill, Terence W.; Bartfai, Gyorgy; Casanueva, Felipe; Forti, Gianni; Rastrelli, Giulia; Giwercman, Aleksander LU ; Han, Thang S and Huhtaniemi, Ilpo T., et al. (2017) In American Journal of Geriatric Psychiatry 25(6). p.662-671
Abstract

Objective: Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. Methods: Over a mean of 4.4 years (SD ± 0.3), men aged 40-79 years from the multicenter European Male Ageing Study were recruited. Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST).... (More)

Objective: Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. Methods: Over a mean of 4.4 years (SD ± 0.3), men aged 40-79 years from the multicenter European Male Ageing Study were recruited. Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results: Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models the presence of baseline MetS was not associated with cognitive decline over time (p > 0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β = -0.42, p < 0.05) and the DSST (β = -0.39, p < 0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline. Conclusion: No evidence was found for a relationship between MetS or inflammation and cognitive decline in this sample of aging men. However, glycemia was negatively associated with visuoconstructional abilities and processing speed.

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publication status
published
subject
keywords
Aging, Cognition, Male health, Metabolic syndrome, Multicenter study
in
American Journal of Geriatric Psychiatry
volume
25
issue
6
pages
662 - 671
publisher
Elsevier
external identifiers
  • scopus:85014102091
  • wos:000405478800015
ISSN
1064-7481
DOI
10.1016/j.jagp.2017.02.004
language
English
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yes
id
043d85c8-aca2-4180-a8d0-f539d3f3933c
date added to LUP
2017-03-16 10:19:34
date last changed
2018-01-07 11:55:47
@article{043d85c8-aca2-4180-a8d0-f539d3f3933c,
  abstract     = {<p>Objective: Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. Methods: Over a mean of 4.4 years (SD ± 0.3), men aged 40-79 years from the multicenter European Male Ageing Study were recruited. Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay. Results: Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models the presence of baseline MetS was not associated with cognitive decline over time (p &gt; 0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β = -0.42, p &lt; 0.05) and the DSST (β = -0.39, p &lt; 0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline. Conclusion: No evidence was found for a relationship between MetS or inflammation and cognitive decline in this sample of aging men. However, glycemia was negatively associated with visuoconstructional abilities and processing speed.</p>},
  author       = {Overman, Margot J. and Pendleton, Neil and O'Neill, Terence W. and Bartfai, Gyorgy and Casanueva, Felipe and Forti, Gianni and Rastrelli, Giulia and Giwercman, Aleksander and Han, Thang S and Huhtaniemi, Ilpo T. and Kula, Krzysztof and Lean, Michael E J and Punab, Margus and Lee, David M. and Correa, Elon S. and Ahern, Tomas and Laurent, Michaël R and Verschueren, Sabine M P and Antonio, Leen and Gielen, Evelien and Rutter, Martin K. and Vanderschueren, Dirk and Wu, Frederick C. W. and Tournoy, Jos},
  issn         = {1064-7481},
  keyword      = {Aging,Cognition,Male health,Metabolic syndrome,Multicenter study},
  language     = {eng},
  month        = {02},
  number       = {6},
  pages        = {662--671},
  publisher    = {Elsevier},
  series       = {American Journal of Geriatric Psychiatry},
  title        = {Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline : Findings from the European Male Ageing Study},
  url          = {http://dx.doi.org/10.1016/j.jagp.2017.02.004},
  volume       = {25},
  year         = {2017},
}