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Circulating syndecans during critical illness

Nelson, Axel LU ; Johansson, Joakim; Tydén, Jonas and Bodelsson, Mikael LU (2017) In APMIS1988-01-01+01:00 125(5). p.468-475
Abstract

Circulating syndecans are proposed to be markers of glycocalyx degradation and previous investigations have found higher plasma levels of syndecan-1 among patients with different pathological conditions. We wanted to investigate if levels of other syndecans (-2,-3 and -4) are altered during critical illness and compare the levels to syndecan-1. In 137 consecutive intensive care unit (ICU) patients with sepsis, cardiac arrest, gastrointestinal bleeding, intoxication or trauma, plasma levels of syndecan-1, -2, -3 and -4 were measured using ELISA. Syndecan-1 and syndecan-3 levels were similar among the different ICU patient groups but higher than controls. No differences in plasma levels of syndecan-2 or syndecan-4 were found neither among... (More)

Circulating syndecans are proposed to be markers of glycocalyx degradation and previous investigations have found higher plasma levels of syndecan-1 among patients with different pathological conditions. We wanted to investigate if levels of other syndecans (-2,-3 and -4) are altered during critical illness and compare the levels to syndecan-1. In 137 consecutive intensive care unit (ICU) patients with sepsis, cardiac arrest, gastrointestinal bleeding, intoxication or trauma, plasma levels of syndecan-1, -2, -3 and -4 were measured using ELISA. Syndecan-1 and syndecan-3 levels were similar among the different ICU patient groups but higher than controls. No differences in plasma levels of syndecan-2 or syndecan-4 were found neither among the different ICU patient groups nor compared to controls. All syndecans showed an association with mortality and the levels of syndecan-1 and -3 and correlated with each other. The results indicate that syndecan release is triggered by the physiological stress of critical illness in general and involves several subtypes such as syndecan-1 and syndecan-3.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Critical illness, Glycocalyx, Syndecan
in
APMIS1988-01-01+01:00
volume
125
issue
5
pages
468 - 475
publisher
John Wiley & Sons
external identifiers
  • scopus:85014165680
  • wos:000402174000006
ISSN
0903-4641
DOI
10.1111/apm.12662
language
English
LU publication?
yes
id
047b7d53-00fa-4df9-90b7-57575485b9ad
date added to LUP
2017-03-15 14:20:36
date last changed
2018-01-12 12:03:23
@article{047b7d53-00fa-4df9-90b7-57575485b9ad,
  abstract     = {<p>Circulating syndecans are proposed to be markers of glycocalyx degradation and previous investigations have found higher plasma levels of syndecan-1 among patients with different pathological conditions. We wanted to investigate if levels of other syndecans (-2,-3 and -4) are altered during critical illness and compare the levels to syndecan-1. In 137 consecutive intensive care unit (ICU) patients with sepsis, cardiac arrest, gastrointestinal bleeding, intoxication or trauma, plasma levels of syndecan-1, -2, -3 and -4 were measured using ELISA. Syndecan-1 and syndecan-3 levels were similar among the different ICU patient groups but higher than controls. No differences in plasma levels of syndecan-2 or syndecan-4 were found neither among the different ICU patient groups nor compared to controls. All syndecans showed an association with mortality and the levels of syndecan-1 and -3 and correlated with each other. The results indicate that syndecan release is triggered by the physiological stress of critical illness in general and involves several subtypes such as syndecan-1 and syndecan-3.</p>},
  author       = {Nelson, Axel and Johansson, Joakim and Tydén, Jonas and Bodelsson, Mikael},
  issn         = {0903-4641},
  keyword      = {Critical illness,Glycocalyx,Syndecan},
  language     = {eng},
  number       = {5},
  pages        = {468--475},
  publisher    = {John Wiley & Sons},
  series       = {APMIS1988-01-01+01:00},
  title        = {Circulating syndecans during critical illness},
  url          = {http://dx.doi.org/10.1111/apm.12662},
  volume       = {125},
  year         = {2017},
}