Circulating syndecans during critical illness
(2017) In APMIS 125(5). p.468-475- Abstract
Circulating syndecans are proposed to be markers of glycocalyx degradation and previous investigations have found higher plasma levels of syndecan-1 among patients with different pathological conditions. We wanted to investigate if levels of other syndecans (-2,-3 and -4) are altered during critical illness and compare the levels to syndecan-1. In 137 consecutive intensive care unit (ICU) patients with sepsis, cardiac arrest, gastrointestinal bleeding, intoxication or trauma, plasma levels of syndecan-1, -2, -3 and -4 were measured using ELISA. Syndecan-1 and syndecan-3 levels were similar among the different ICU patient groups but higher than controls. No differences in plasma levels of syndecan-2 or syndecan-4 were found neither among... (More)
Circulating syndecans are proposed to be markers of glycocalyx degradation and previous investigations have found higher plasma levels of syndecan-1 among patients with different pathological conditions. We wanted to investigate if levels of other syndecans (-2,-3 and -4) are altered during critical illness and compare the levels to syndecan-1. In 137 consecutive intensive care unit (ICU) patients with sepsis, cardiac arrest, gastrointestinal bleeding, intoxication or trauma, plasma levels of syndecan-1, -2, -3 and -4 were measured using ELISA. Syndecan-1 and syndecan-3 levels were similar among the different ICU patient groups but higher than controls. No differences in plasma levels of syndecan-2 or syndecan-4 were found neither among the different ICU patient groups nor compared to controls. All syndecans showed an association with mortality and the levels of syndecan-1 and -3 and correlated with each other. The results indicate that syndecan release is triggered by the physiological stress of critical illness in general and involves several subtypes such as syndecan-1 and syndecan-3.
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- author
- Nelson, Axel LU ; Johansson, Joakim ; Tydén, Jonas and Bodelsson, Mikael LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Critical illness, Glycocalyx, Syndecan
- in
- APMIS
- volume
- 125
- issue
- 5
- pages
- 468 - 475
- publisher
- Blackwell Munksgaard
- external identifiers
-
- pmid:28256016
- wos:000402174000006
- scopus:85014165680
- ISSN
- 0903-4641
- DOI
- 10.1111/apm.12662
- language
- English
- LU publication?
- yes
- id
- 047b7d53-00fa-4df9-90b7-57575485b9ad
- date added to LUP
- 2017-03-15 14:20:36
- date last changed
- 2025-02-03 12:28:43
@article{047b7d53-00fa-4df9-90b7-57575485b9ad,
abstract = {{<p>Circulating syndecans are proposed to be markers of glycocalyx degradation and previous investigations have found higher plasma levels of syndecan-1 among patients with different pathological conditions. We wanted to investigate if levels of other syndecans (-2,-3 and -4) are altered during critical illness and compare the levels to syndecan-1. In 137 consecutive intensive care unit (ICU) patients with sepsis, cardiac arrest, gastrointestinal bleeding, intoxication or trauma, plasma levels of syndecan-1, -2, -3 and -4 were measured using ELISA. Syndecan-1 and syndecan-3 levels were similar among the different ICU patient groups but higher than controls. No differences in plasma levels of syndecan-2 or syndecan-4 were found neither among the different ICU patient groups nor compared to controls. All syndecans showed an association with mortality and the levels of syndecan-1 and -3 and correlated with each other. The results indicate that syndecan release is triggered by the physiological stress of critical illness in general and involves several subtypes such as syndecan-1 and syndecan-3.</p>}},
author = {{Nelson, Axel and Johansson, Joakim and Tydén, Jonas and Bodelsson, Mikael}},
issn = {{0903-4641}},
keywords = {{Critical illness; Glycocalyx; Syndecan}},
language = {{eng}},
number = {{5}},
pages = {{468--475}},
publisher = {{Blackwell Munksgaard}},
series = {{APMIS}},
title = {{Circulating syndecans during critical illness}},
url = {{http://dx.doi.org/10.1111/apm.12662}},
doi = {{10.1111/apm.12662}},
volume = {{125}},
year = {{2017}},
}