Phosphatidylethanol: normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports
(2010) In Addiction Biology 15(1). p.88-95- Abstract
- Phosphatidylethanol (PEth) is a direct ethanol metabolite, and has recently attracted attention as biomarker of ethanol intake. The aims of the current study are: (1) to characterize the normalization time of PEth in larger samples than previously conducted; (2) to elucidate potential gender differences; and (3) to report the correlation of PEth with other biomarkers and self-reported alcohol consumption. Fifty-seven alcohol-dependent patients (ICD 10 F 10.25; 9 females, 48 males) entering medical detoxification at three study sites were enrolled. The study sample was comprised of 48 males and 9 females, with mean age 43.5. Mean gamma glutamyl transpeptidase (GGT) was 209.61 U/l, average mean corpuscular volume (MCV) was 97.35 fl, mean... (More)
- Phosphatidylethanol (PEth) is a direct ethanol metabolite, and has recently attracted attention as biomarker of ethanol intake. The aims of the current study are: (1) to characterize the normalization time of PEth in larger samples than previously conducted; (2) to elucidate potential gender differences; and (3) to report the correlation of PEth with other biomarkers and self-reported alcohol consumption. Fifty-seven alcohol-dependent patients (ICD 10 F 10.25; 9 females, 48 males) entering medical detoxification at three study sites were enrolled. The study sample was comprised of 48 males and 9 females, with mean age 43.5. Mean gamma glutamyl transpeptidase (GGT) was 209.61 U/l, average mean corpuscular volume (MCV) was 97.35 fl, mean carbohydrate deficient transferrin (%CDT) was 8.68, and mean total ethanol intake in the last 7 days was 1653 g. PEth was measured in heparinized whole blood with a high-pressure liquid chromatography method, while GGT, MCV and %CDT were measured using routine methods. PEth levels at day 1 of detoxification ranged between 0.63 and 26.95 mu mol/l (6.22 mean, 4.70 median, SD 4.97). There were no false negatives at day 1. Sensitivities for the other biomarkers were 40.4% for MCV, 73.1% for GGT and 69.2% for %CDT, respectively. No gender differences were found for PEth levels at any time point. Our data suggest that PEth is (1) a suitable intermediate term marker of ethanol intake in both sexes; and (2) sensitivity is extraordinary high in alcohol dependent patients. The results add further evidence to the data that suggest that PEth has potential as a candidate for a sensitive and specific biomarker, which reflects longer-lasting intake of higher amounts of alcohol and seemingly has the above mentioned certain advantages over traditional biomarkers. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1535654
- author
- Wurst, Friedrich Martin ; Thon, Natasha ; Aradottir, Steina LU ; Hartmann, Susanne ; Wiesbeck, Gerhard Adam ; Lesch, Otto ; Skala, Katrin ; Wolfersdorf, Manfred ; Weinmann, Wolfgang and Alling, Christer LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- harmful ethanol intake, gamma glutamyl transpeptidase, gender aspects, mean corpuscular volume, phosphatidylethanol, sensitivity
- in
- Addiction Biology
- volume
- 15
- issue
- 1
- pages
- 88 - 95
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000272565100009
- scopus:71949091346
- pmid:20002024
- ISSN
- 1369-1600
- DOI
- 10.1111/j.1369-1600.2009.00185.x
- language
- English
- LU publication?
- yes
- id
- 0480f69e-0d1a-4bbf-add0-b25cbff7b7bd (old id 1535654)
- date added to LUP
- 2016-04-01 11:12:41
- date last changed
- 2022-04-05 00:50:18
@article{0480f69e-0d1a-4bbf-add0-b25cbff7b7bd,
abstract = {{Phosphatidylethanol (PEth) is a direct ethanol metabolite, and has recently attracted attention as biomarker of ethanol intake. The aims of the current study are: (1) to characterize the normalization time of PEth in larger samples than previously conducted; (2) to elucidate potential gender differences; and (3) to report the correlation of PEth with other biomarkers and self-reported alcohol consumption. Fifty-seven alcohol-dependent patients (ICD 10 F 10.25; 9 females, 48 males) entering medical detoxification at three study sites were enrolled. The study sample was comprised of 48 males and 9 females, with mean age 43.5. Mean gamma glutamyl transpeptidase (GGT) was 209.61 U/l, average mean corpuscular volume (MCV) was 97.35 fl, mean carbohydrate deficient transferrin (%CDT) was 8.68, and mean total ethanol intake in the last 7 days was 1653 g. PEth was measured in heparinized whole blood with a high-pressure liquid chromatography method, while GGT, MCV and %CDT were measured using routine methods. PEth levels at day 1 of detoxification ranged between 0.63 and 26.95 mu mol/l (6.22 mean, 4.70 median, SD 4.97). There were no false negatives at day 1. Sensitivities for the other biomarkers were 40.4% for MCV, 73.1% for GGT and 69.2% for %CDT, respectively. No gender differences were found for PEth levels at any time point. Our data suggest that PEth is (1) a suitable intermediate term marker of ethanol intake in both sexes; and (2) sensitivity is extraordinary high in alcohol dependent patients. The results add further evidence to the data that suggest that PEth has potential as a candidate for a sensitive and specific biomarker, which reflects longer-lasting intake of higher amounts of alcohol and seemingly has the above mentioned certain advantages over traditional biomarkers.}},
author = {{Wurst, Friedrich Martin and Thon, Natasha and Aradottir, Steina and Hartmann, Susanne and Wiesbeck, Gerhard Adam and Lesch, Otto and Skala, Katrin and Wolfersdorf, Manfred and Weinmann, Wolfgang and Alling, Christer}},
issn = {{1369-1600}},
keywords = {{harmful ethanol intake; gamma glutamyl transpeptidase; gender aspects; mean corpuscular volume; phosphatidylethanol; sensitivity}},
language = {{eng}},
number = {{1}},
pages = {{88--95}},
publisher = {{Wiley-Blackwell}},
series = {{Addiction Biology}},
title = {{Phosphatidylethanol: normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports}},
url = {{http://dx.doi.org/10.1111/j.1369-1600.2009.00185.x}},
doi = {{10.1111/j.1369-1600.2009.00185.x}},
volume = {{15}},
year = {{2010}},
}