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Interaction between angiotensin type 1, type 2, and mas receptors to regulate adult neurogenesis in the brain ventricular–subventricular zone

Garcia-Garrote, Maria LU orcid ; Perez-Villalba, Ana ; Garrido-Gil, Pablo ; Belenguer, German ; Parga, Juan A. ; Perez-Sanchez, Francisco ; Labandeira-Garcia, Jose Luis ; Fariñas, Isabel and Rodriguez-Pallares, Jannette (2019) In Cells 8(12).
Abstract

The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have not been investigated. In the present study, we analyzed the role of major RAS receptors on neurogenesis in the V-SVZ of adult mice and rats. In mice, we showed that the increase in proliferation of cells in this neurogenic niche was induced by activation of AT2 receptors but depended partially on the AT2-dependent antagonism of AT1 receptor expression, which restricted proliferation. Furthermore, we... (More)

The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have not been investigated. In the present study, we analyzed the role of major RAS receptors on neurogenesis in the V-SVZ of adult mice and rats. In mice, we showed that the increase in proliferation of cells in this neurogenic niche was induced by activation of AT2 receptors but depended partially on the AT2-dependent antagonism of AT1 receptor expression, which restricted proliferation. Furthermore, we observed a functional dependence of AT2 receptor actions on Mas receptors. In rats, where the levels of the AT1 relative to those of AT2 receptor are much lower, pharmacological inhibition of the AT1 receptor alone was sufficient in increasing AT2 receptor levels and proliferation in the V-SVZ. Our data revealed that interactions between RAS receptors play a major role in the regulation of V-SVZ neurogenesis, particularly in proliferation, generation of neuroblasts, and migration to the olfactory bulb, both in young and aged brains, and suggest potential beneficial effects of RAS modulators on neurogenesis.

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author
; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, AT1 receptors, AT2 receptors, Neural stem cells, Neurospheres, Proliferation, Subventricular zone, Ventricular
in
Cells
volume
8
issue
12
article number
1551
publisher
MDPI AG
external identifiers
  • scopus:85086085009
  • pmid:31801296
ISSN
2073-4409
DOI
10.3390/cells8121551
language
English
LU publication?
no
additional info
Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
id
04a25fba-5ff6-4560-a8fc-01f60c47a1d0
date added to LUP
2025-01-24 12:05:33
date last changed
2025-07-12 13:03:30
@article{04a25fba-5ff6-4560-a8fc-01f60c47a1d0,
  abstract     = {{<p>The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have not been investigated. In the present study, we analyzed the role of major RAS receptors on neurogenesis in the V-SVZ of adult mice and rats. In mice, we showed that the increase in proliferation of cells in this neurogenic niche was induced by activation of AT2 receptors but depended partially on the AT2-dependent antagonism of AT1 receptor expression, which restricted proliferation. Furthermore, we observed a functional dependence of AT2 receptor actions on Mas receptors. In rats, where the levels of the AT1 relative to those of AT2 receptor are much lower, pharmacological inhibition of the AT1 receptor alone was sufficient in increasing AT2 receptor levels and proliferation in the V-SVZ. Our data revealed that interactions between RAS receptors play a major role in the regulation of V-SVZ neurogenesis, particularly in proliferation, generation of neuroblasts, and migration to the olfactory bulb, both in young and aged brains, and suggest potential beneficial effects of RAS modulators on neurogenesis.</p>}},
  author       = {{Garcia-Garrote, Maria and Perez-Villalba, Ana and Garrido-Gil, Pablo and Belenguer, German and Parga, Juan A. and Perez-Sanchez, Francisco and Labandeira-Garcia, Jose Luis and Fariñas, Isabel and Rodriguez-Pallares, Jannette}},
  issn         = {{2073-4409}},
  keywords     = {{Aging; AT1 receptors; AT2 receptors; Neural stem cells; Neurospheres; Proliferation; Subventricular zone; Ventricular}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{MDPI AG}},
  series       = {{Cells}},
  title        = {{Interaction between angiotensin type 1, type 2, and mas receptors to regulate adult neurogenesis in the brain ventricular–subventricular zone}},
  url          = {{http://dx.doi.org/10.3390/cells8121551}},
  doi          = {{10.3390/cells8121551}},
  volume       = {{8}},
  year         = {{2019}},
}