Induction chemotherapy with versus without hormonal synchronisation in locally advanced breast cancer
(1997) In Acta oncologica (Stockholm, Sweden) 36(2). p.12-207- Abstract
Sixty-nine patients with locally advanced breast cancer were given induction chemotherapy with doxorubicin and cyclophosphamide (day 1) followed by methotrexate and 5-Fu (day 8). Thirty-two of these patients were also given tamoxifen (days 2-6) in an attempt to induce a G1 arrest in cancer cells, and oestrogen (days 7-8) to stimulate proliferation and thus induce a synchronized wave of proliferating cells. The induction therapy response rate was 61% in the series as a whole (n = 69), but was found to be significantly better in the group on the tamoxifen/oestrogen synchronization regimen than in the remainder on chemotherapy alone (82% vs. 43%). This difference was particularly marked in the respective receptor-positive subgroups [90%... (More)
Sixty-nine patients with locally advanced breast cancer were given induction chemotherapy with doxorubicin and cyclophosphamide (day 1) followed by methotrexate and 5-Fu (day 8). Thirty-two of these patients were also given tamoxifen (days 2-6) in an attempt to induce a G1 arrest in cancer cells, and oestrogen (days 7-8) to stimulate proliferation and thus induce a synchronized wave of proliferating cells. The induction therapy response rate was 61% in the series as a whole (n = 69), but was found to be significantly better in the group on the tamoxifen/oestrogen synchronization regimen than in the remainder on chemotherapy alone (82% vs. 43%). This difference was particularly marked in the respective receptor-positive subgroups [90% (9/10) vs. 30% (3/10); p < 0.001]. The findings suggest that, in combination with chemotherapy, tamoxifen/oestrogen therapy, given in the sequence outlined here, constitutes a promising regimen for the treatment of locally advanced receptor-positive breast cancer patients.
(Less)
- author
- Palm Sjövall, Margareta and Malmström, Per LU
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Hormonal/adverse effects, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Breast Neoplasms/drug therapy, Cell Division/drug effects, Disease Progression, Estrogens/administration & dosage, Female, Fluorouracil/administration & dosage, G1 Phase/drug effects, Humans, Methotrexate/administration & dosage, Middle Aged, Neoplasms, Hormone-Dependent/drug therapy, Remission Induction, Tamoxifen/administration & dosage
- in
- Acta oncologica (Stockholm, Sweden)
- volume
- 36
- issue
- 2
- pages
- 12 - 207
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:0030612261
- pmid:9140439
- ISSN
- 0284-186X
- DOI
- 10.3109/02841869709109231
- language
- English
- LU publication?
- no
- id
- 04dd748c-b01c-42db-b3e1-4b489e8a83b7
- date added to LUP
- 2022-03-01 09:27:21
- date last changed
- 2024-01-04 23:16:11
@article{04dd748c-b01c-42db-b3e1-4b489e8a83b7,
abstract = {{<p>Sixty-nine patients with locally advanced breast cancer were given induction chemotherapy with doxorubicin and cyclophosphamide (day 1) followed by methotrexate and 5-Fu (day 8). Thirty-two of these patients were also given tamoxifen (days 2-6) in an attempt to induce a G1 arrest in cancer cells, and oestrogen (days 7-8) to stimulate proliferation and thus induce a synchronized wave of proliferating cells. The induction therapy response rate was 61% in the series as a whole (n = 69), but was found to be significantly better in the group on the tamoxifen/oestrogen synchronization regimen than in the remainder on chemotherapy alone (82% vs. 43%). This difference was particularly marked in the respective receptor-positive subgroups [90% (9/10) vs. 30% (3/10); p < 0.001]. The findings suggest that, in combination with chemotherapy, tamoxifen/oestrogen therapy, given in the sequence outlined here, constitutes a promising regimen for the treatment of locally advanced receptor-positive breast cancer patients.</p>}},
author = {{Palm Sjövall, Margareta and Malmström, Per}},
issn = {{0284-186X}},
keywords = {{Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal/adverse effects; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Breast Neoplasms/drug therapy; Cell Division/drug effects; Disease Progression; Estrogens/administration & dosage; Female; Fluorouracil/administration & dosage; G1 Phase/drug effects; Humans; Methotrexate/administration & dosage; Middle Aged; Neoplasms, Hormone-Dependent/drug therapy; Remission Induction; Tamoxifen/administration & dosage}},
language = {{eng}},
number = {{2}},
pages = {{12--207}},
publisher = {{Taylor & Francis}},
series = {{Acta oncologica (Stockholm, Sweden)}},
title = {{Induction chemotherapy with versus without hormonal synchronisation in locally advanced breast cancer}},
url = {{http://dx.doi.org/10.3109/02841869709109231}},
doi = {{10.3109/02841869709109231}},
volume = {{36}},
year = {{1997}},
}