Neuropeptide Y : prejunctional inhibition of vagally induced contractions in the guinea pig trachea
(1988) In Regulatory Peptides 23(3). p.309-313- Abstract
The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.
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- author
- Grundemar, L LU ; Widmark, Erik ; Waldeck, B LU and Håkanson, R LU
- organization
- publishing date
- 1988-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Carbachol/pharmacology, Dose-Response Relationship, Drug, Electric Stimulation, Guinea Pigs, Male, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Neuropeptide Y/pharmacology, Trachea/drug effects, Vagus Nerve/drug effects
- in
- Regulatory Peptides
- volume
- 23
- issue
- 3
- pages
- 309 - 313
- publisher
- Elsevier
- external identifiers
-
- pmid:3238053
- scopus:0024240930
- ISSN
- 0167-0115
- DOI
- 10.1016/0167-0115(88)90231-5
- language
- English
- LU publication?
- yes
- id
- 05243db3-8f18-4c88-b64e-baddfd25ab4a
- date added to LUP
- 2019-09-03 14:14:42
- date last changed
- 2024-01-01 18:56:55
@article{05243db3-8f18-4c88-b64e-baddfd25ab4a, abstract = {{<p>The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.</p>}}, author = {{Grundemar, L and Widmark, Erik and Waldeck, B and Håkanson, R}}, issn = {{0167-0115}}, keywords = {{Animals; Carbachol/pharmacology; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Male; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Neuropeptide Y/pharmacology; Trachea/drug effects; Vagus Nerve/drug effects}}, language = {{eng}}, number = {{3}}, pages = {{309--313}}, publisher = {{Elsevier}}, series = {{Regulatory Peptides}}, title = {{Neuropeptide Y : prejunctional inhibition of vagally induced contractions in the guinea pig trachea}}, url = {{http://dx.doi.org/10.1016/0167-0115(88)90231-5}}, doi = {{10.1016/0167-0115(88)90231-5}}, volume = {{23}}, year = {{1988}}, }