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Neuropeptide Y : prejunctional inhibition of vagally induced contractions in the guinea pig trachea

Grundemar, L LU ; Widmark, Erik ; Waldeck, B LU and Håkanson, R LU (1988) In Regulatory Peptides 23(3). p.309-313
Abstract

The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Animals, Carbachol/pharmacology, Dose-Response Relationship, Drug, Electric Stimulation, Guinea Pigs, Male, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Neuropeptide Y/pharmacology, Trachea/drug effects, Vagus Nerve/drug effects
in
Regulatory Peptides
volume
23
issue
3
pages
309 - 313
publisher
Elsevier
external identifiers
  • pmid:3238053
  • scopus:0024240930
ISSN
0167-0115
DOI
10.1016/0167-0115(88)90231-5
language
English
LU publication?
yes
id
05243db3-8f18-4c88-b64e-baddfd25ab4a
date added to LUP
2019-09-03 14:14:42
date last changed
2020-01-13 02:19:33
@article{05243db3-8f18-4c88-b64e-baddfd25ab4a,
  abstract     = {<p>The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.</p>},
  author       = {Grundemar, L and Widmark, Erik and Waldeck, B and Håkanson, R},
  issn         = {0167-0115},
  language     = {eng},
  number       = {3},
  pages        = {309--313},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {Neuropeptide Y : prejunctional inhibition of vagally induced contractions in the guinea pig trachea},
  url          = {http://dx.doi.org/10.1016/0167-0115(88)90231-5},
  doi          = {10.1016/0167-0115(88)90231-5},
  volume       = {23},
  year         = {1988},
}