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The prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer : a multi-center study with a propensity score-adjusted analysis

Miyamoto, Emiri ; Suzuki, Hironori ; Yoshihara, Masato ; Mogi, Kazumasa ; Iyoshi, Shohei ; Uno, Kaname LU orcid ; Fujimoto, Hiroki ; Kitami, Kazuhisa ; Tano, Sho and Emoto, Ryo , et al. (2023) In Japanese journal of clinical oncology 53(8). p.698-703
Abstract

Objective: Complete-staging surgery is recommended for stage IA ovarian cancer, but may be omitted for various reasons, including the preservation of fertility and an advanced age. We herein investigated the prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer. Methods: We retrospectively collected data on 4730 patients with malignant ovarian tumors from the databases of multiple institutions and ultimately included 293 with stage IA epithelial ovarian cancer. Limited-staging surgery was defined as one that did not involve hysterectomy, systematic retroperitoneal lymphadenectomy or the collection of ascites cytology. We used an inverse probability of treatment weighting analysis with... (More)

Objective: Complete-staging surgery is recommended for stage IA ovarian cancer, but may be omitted for various reasons, including the preservation of fertility and an advanced age. We herein investigated the prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer. Methods: We retrospectively collected data on 4730 patients with malignant ovarian tumors from the databases of multiple institutions and ultimately included 293 with stage IA epithelial ovarian cancer. Limited-staging surgery was defined as one that did not involve hysterectomy, systematic retroperitoneal lymphadenectomy or the collection of ascites cytology. We used an inverse probability of treatment weighting analysis with propensity scores and estimated the hazard ratios of recurrence and death with limited-staging surgery. Results: In total, 176 out of 293 patients (39.9%) were assigned to the limited-staging surgery group. After propensity score adjustments, no significant differences were observed in recurrence-free survival or overall survival between the limited- and complete-staging surgery groups. Even in the subgroup analysis with age stratification, recurrence-free survival and overall survival were similar in the limited- and complete-staging surgery groups. Conclusions: The present results indicate the limited prognostic impact of limited-staging surgery for stage IA epithelial ovarian cancer.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ascites cytology, fertility-sparing surgery, lymphadenectomy, ovarian cancer
in
Japanese journal of clinical oncology
volume
53
issue
8
pages
6 pages
publisher
Oxford University Press
external identifiers
  • pmid:37236812
  • scopus:85166387009
ISSN
0368-2811
DOI
10.1093/jjco/hyad039
language
English
LU publication?
yes
id
052b2823-eaf0-470f-9d87-dd47228322fb
date added to LUP
2023-11-02 12:16:30
date last changed
2024-04-19 03:27:43
@article{052b2823-eaf0-470f-9d87-dd47228322fb,
  abstract     = {{<p>Objective: Complete-staging surgery is recommended for stage IA ovarian cancer, but may be omitted for various reasons, including the preservation of fertility and an advanced age. We herein investigated the prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer. Methods: We retrospectively collected data on 4730 patients with malignant ovarian tumors from the databases of multiple institutions and ultimately included 293 with stage IA epithelial ovarian cancer. Limited-staging surgery was defined as one that did not involve hysterectomy, systematic retroperitoneal lymphadenectomy or the collection of ascites cytology. We used an inverse probability of treatment weighting analysis with propensity scores and estimated the hazard ratios of recurrence and death with limited-staging surgery. Results: In total, 176 out of 293 patients (39.9%) were assigned to the limited-staging surgery group. After propensity score adjustments, no significant differences were observed in recurrence-free survival or overall survival between the limited- and complete-staging surgery groups. Even in the subgroup analysis with age stratification, recurrence-free survival and overall survival were similar in the limited- and complete-staging surgery groups. Conclusions: The present results indicate the limited prognostic impact of limited-staging surgery for stage IA epithelial ovarian cancer.</p>}},
  author       = {{Miyamoto, Emiri and Suzuki, Hironori and Yoshihara, Masato and Mogi, Kazumasa and Iyoshi, Shohei and Uno, Kaname and Fujimoto, Hiroki and Kitami, Kazuhisa and Tano, Sho and Emoto, Ryo and Matsui, Shigeyuki and Kajiyama, Hiroaki}},
  issn         = {{0368-2811}},
  keywords     = {{ascites cytology; fertility-sparing surgery; lymphadenectomy; ovarian cancer}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{698--703}},
  publisher    = {{Oxford University Press}},
  series       = {{Japanese journal of clinical oncology}},
  title        = {{The prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer : a multi-center study with a propensity score-adjusted analysis}},
  url          = {{http://dx.doi.org/10.1093/jjco/hyad039}},
  doi          = {{10.1093/jjco/hyad039}},
  volume       = {{53}},
  year         = {{2023}},
}