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Comorbidities in patients with antineutrophil cytoplasmic antibody-associated vasculitis versus the general population

Englund, Martin LU ; Merkel, Peter A.; Tomasson, Gunnar; Segelmark, Mårten LU and Mohammad, Aladdin J. LU (2016) In Journal of Rheumatology 43(8). p.1553-1558
Abstract

Objective. To evaluate the consultation rates of selected comorbidities in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) compared with the general population in southern Sweden. Methods. We used data from a population-based cohort of patients with AAV diagnosed between 1998 and 2010 in Southern Sweden (701,000 inhabitants). For each patient we identified 4 reference subjects randomly sampled from the general population and matched for year of birth, sex, area of residence, and index year. Using the population-based Skåne Healthcare Register, we identified relevant diagnostic codes, registered between 1998 and 2011, for selected comorbidities assigned after the date of diagnosis of AAV or the index date... (More)

Objective. To evaluate the consultation rates of selected comorbidities in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) compared with the general population in southern Sweden. Methods. We used data from a population-based cohort of patients with AAV diagnosed between 1998 and 2010 in Southern Sweden (701,000 inhabitants). For each patient we identified 4 reference subjects randomly sampled from the general population and matched for year of birth, sex, area of residence, and index year. Using the population-based Skåne Healthcare Register, we identified relevant diagnostic codes, registered between 1998 and 2011, for selected comorbidities assigned after the date of diagnosis of AAV or the index date for the reference subjects. We calculated rate ratios for comorbidities (AAV:reference subjects). Results. There were 186 patients with AAV (95 women, mean age 64.5 yrs) and 744 reference persons included in the analysis. The highest rate ratios (AAV:reference) were obtained for osteoporosis (4.6, 95% CI 3.0-7.0), followed by venous thromboembolism (4.0, 95% CI 1.9-8.3), thyroid diseases (2.1, 95% CI 1.3-3.3), and diabetes mellitus (2.0, 95% CI 1.3-2.9). For ischemic heart disease, the rate ratio of 1.5 (95% CI 1.0-2.3) did not reach statistical significance. No statistically significant differences were found for cerebrovascular accidents. Conclusion. AAV is associated with increased consultation rates of several comorbidities including osteoporosis and thromboembolic and endocrine disorders. Comorbid conditions should be taken into consideration when planning and providing care for patients with AAV.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anca-associated vasculitis, Antineutrophil cytoplasmic antibodies, Comorbidities, Outcome, Population-based study
in
Journal of Rheumatology
volume
43
issue
8
pages
6 pages
publisher
J Rheumatol Publ Co
external identifiers
  • Scopus:84982822199
  • WOS:000380882300017
ISSN
0315-162X
DOI
10.3899/jrheum.151151
language
English
LU publication?
yes
id
052c7447-c072-4d41-abfd-3db89aadedcf
date added to LUP
2016-09-20 18:00:32
date last changed
2017-01-03 14:35:38
@article{052c7447-c072-4d41-abfd-3db89aadedcf,
  abstract     = {<p>Objective. To evaluate the consultation rates of selected comorbidities in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) compared with the general population in southern Sweden. Methods. We used data from a population-based cohort of patients with AAV diagnosed between 1998 and 2010 in Southern Sweden (701,000 inhabitants). For each patient we identified 4 reference subjects randomly sampled from the general population and matched for year of birth, sex, area of residence, and index year. Using the population-based Skåne Healthcare Register, we identified relevant diagnostic codes, registered between 1998 and 2011, for selected comorbidities assigned after the date of diagnosis of AAV or the index date for the reference subjects. We calculated rate ratios for comorbidities (AAV:reference subjects). Results. There were 186 patients with AAV (95 women, mean age 64.5 yrs) and 744 reference persons included in the analysis. The highest rate ratios (AAV:reference) were obtained for osteoporosis (4.6, 95% CI 3.0-7.0), followed by venous thromboembolism (4.0, 95% CI 1.9-8.3), thyroid diseases (2.1, 95% CI 1.3-3.3), and diabetes mellitus (2.0, 95% CI 1.3-2.9). For ischemic heart disease, the rate ratio of 1.5 (95% CI 1.0-2.3) did not reach statistical significance. No statistically significant differences were found for cerebrovascular accidents. Conclusion. AAV is associated with increased consultation rates of several comorbidities including osteoporosis and thromboembolic and endocrine disorders. Comorbid conditions should be taken into consideration when planning and providing care for patients with AAV.</p>},
  author       = {Englund, Martin and Merkel, Peter A. and Tomasson, Gunnar and Segelmark, Mårten and Mohammad, Aladdin J.},
  issn         = {0315-162X},
  keyword      = {Anca-associated vasculitis,Antineutrophil cytoplasmic antibodies,Comorbidities,Outcome,Population-based study},
  language     = {eng},
  month        = {08},
  number       = {8},
  pages        = {1553--1558},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {Comorbidities in patients with antineutrophil cytoplasmic antibody-associated vasculitis versus the general population},
  url          = {http://dx.doi.org/10.3899/jrheum.151151},
  volume       = {43},
  year         = {2016},
}