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Association of Epicardial Fat Volume With the Extent of Coronary Atherosclerosis and Cardiovascular Adverse Events in Asymptomatic Patients With Diabetes

Venuraju, Shreenidhi M. ; Lahiri, Avijit ; Jeevarethinam, Anand ; Rakhit, Roby D. ; Shah, Prediman K. and Nilsson, Jan LU (2021) In Angiology 72(5). p.442-450
Abstract

Epicardial adipose tissue has a paracrine effect, enhancing coronary artery atherosclerotic plaque development. This study evaluated epicardial fat volume (EFV), adipokines, coronary atherosclerosis, and adverse cardiovascular events in a cohort of asymptomatic patients with type 2 diabetes mellitus (T2DM). Epicardial fat volume was calculated using data from computed tomography coronary angiograms. Adipokines and inflammatory cytokines were also assayed and correlated with EFV. Epicardial fat volume was also assessed as a predictor of coronary artery calcium (CAC) score, number of coronary artery plaques, and significant plaque (>50% luminal stenosis). Data from the EFV analysis were available for 221 (85.7%) participants. Median... (More)

Epicardial adipose tissue has a paracrine effect, enhancing coronary artery atherosclerotic plaque development. This study evaluated epicardial fat volume (EFV), adipokines, coronary atherosclerosis, and adverse cardiovascular events in a cohort of asymptomatic patients with type 2 diabetes mellitus (T2DM). Epicardial fat volume was calculated using data from computed tomography coronary angiograms. Adipokines and inflammatory cytokines were also assayed and correlated with EFV. Epicardial fat volume was also assessed as a predictor of coronary artery calcium (CAC) score, number of coronary artery plaques, and significant plaque (>50% luminal stenosis). Data from the EFV analysis were available for 221 (85.7%) participants. Median EFV was 97.4 cm3, mean body mass index was 28.1 kg/m2, and mean duration of T2DM was 13 years. Statistically significant, but weak, correlations were observed between several adipokines, inflammatory cytokines, and EFV. Epicardial fat volume was a significant univariate (P =.01), but not multivariate, predictor of the number of coronary plaques, but not of CAC score or significant plaque. After a mean follow-up of 22.8 months, 12 adverse cardiovascular events were reported, exclusively in participants with EFV >97.4 cm3. Epicardial fat volume has limited utility as a marker of coronary artery plaque in patients with T2DM and is weakly correlated with adipokine expression.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarkers, coronary angiography, coronary atherosclerosis, epicardial adipose tissue thickness, major adverse cardiac events, type 2 diabetes mellitus
in
Angiology
volume
72
issue
5
pages
442 - 450
publisher
SAGE Publications
external identifiers
  • pmid:33467865
  • scopus:85099952281
ISSN
0003-3197
DOI
10.1177/0003319720984607
language
English
LU publication?
yes
id
054cb775-c63f-4126-9bae-ada37de022b5
date added to LUP
2021-02-10 09:30:51
date last changed
2024-04-03 23:37:45
@article{054cb775-c63f-4126-9bae-ada37de022b5,
  abstract     = {{<p>Epicardial adipose tissue has a paracrine effect, enhancing coronary artery atherosclerotic plaque development. This study evaluated epicardial fat volume (EFV), adipokines, coronary atherosclerosis, and adverse cardiovascular events in a cohort of asymptomatic patients with type 2 diabetes mellitus (T2DM). Epicardial fat volume was calculated using data from computed tomography coronary angiograms. Adipokines and inflammatory cytokines were also assayed and correlated with EFV. Epicardial fat volume was also assessed as a predictor of coronary artery calcium (CAC) score, number of coronary artery plaques, and significant plaque (&gt;50% luminal stenosis). Data from the EFV analysis were available for 221 (85.7%) participants. Median EFV was 97.4 cm<sup>3</sup>, mean body mass index was 28.1 kg/m<sup>2</sup>, and mean duration of T2DM was 13 years. Statistically significant, but weak, correlations were observed between several adipokines, inflammatory cytokines, and EFV. Epicardial fat volume was a significant univariate (P =.01), but not multivariate, predictor of the number of coronary plaques, but not of CAC score or significant plaque. After a mean follow-up of 22.8 months, 12 adverse cardiovascular events were reported, exclusively in participants with EFV &gt;97.4 cm<sup>3</sup>. Epicardial fat volume has limited utility as a marker of coronary artery plaque in patients with T2DM and is weakly correlated with adipokine expression.</p>}},
  author       = {{Venuraju, Shreenidhi M. and Lahiri, Avijit and Jeevarethinam, Anand and Rakhit, Roby D. and Shah, Prediman K. and Nilsson, Jan}},
  issn         = {{0003-3197}},
  keywords     = {{biomarkers; coronary angiography; coronary atherosclerosis; epicardial adipose tissue thickness; major adverse cardiac events; type 2 diabetes mellitus}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{5}},
  pages        = {{442--450}},
  publisher    = {{SAGE Publications}},
  series       = {{Angiology}},
  title        = {{Association of Epicardial Fat Volume With the Extent of Coronary Atherosclerosis and Cardiovascular Adverse Events in Asymptomatic Patients With Diabetes}},
  url          = {{http://dx.doi.org/10.1177/0003319720984607}},
  doi          = {{10.1177/0003319720984607}},
  volume       = {{72}},
  year         = {{2021}},
}