Tendon mechanobiology in small animal experiments during post-transection healing
(2021) In European Cells and Materials 42. p.375-391- Abstract
- Ruptures to tendons are common and costly, and no clinical consensus exists on the appropriate treatment and rehabilitation regimen to promote their healing as well as full recovery of functionality. Although mechanobiology is known to play an important role in tendon regeneration, the understanding of how mechano-regulated processes affect tendon healing needs further clarification. Many small-animal studies, particularly in rats and mice, have characterized the progression of healing in terms of geometrical, structural, compositional, mechanical, and cellular properties. Some of the properties are also studied under different mechanical loading regimens. The focus of this review is to summarize and generalize the information in the... (More)
- Ruptures to tendons are common and costly, and no clinical consensus exists on the appropriate treatment and rehabilitation regimen to promote their healing as well as full recovery of functionality. Although mechanobiology is known to play an important role in tendon regeneration, the understanding of how mechano-regulated processes affect tendon healing needs further clarification. Many small-animal studies, particularly in rats and mice, have characterized the progression of healing in terms of geometrical, structural, compositional, mechanical, and cellular properties. Some of the properties are also studied under different mechanical loading regimens. The focus of this review is to summarize and generalize the information in the literature regarding spatial and temporal differentiation of tendon properties during rodent tendon healing following full-tendon transection, as well as how this is affected by altered in vivo loading regimens. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/057a5846-074c-48d9-9e9a-f491b1dec099
- author
- Notermans, Thomas LU ; Hammerman, Malin LU ; Eliasson, Pernilla and Isaksson, Hanna LU
- organization
- publishing date
- 2021-11-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Collagen, extracellular matrix, rupture, achilles tendon, cells, unloading, Immobilization, tissue differentiation, mechanical, heterogeneous
- in
- European Cells and Materials
- volume
- 42
- pages
- 17 pages
- publisher
- Swiss Society for Biomaterials
- external identifiers
-
- pmid:34725807
- scopus:85121483858
- ISSN
- 1473-2262
- DOI
- 10.22203/eCM.v042a23
- language
- English
- LU publication?
- yes
- id
- 057a5846-074c-48d9-9e9a-f491b1dec099
- date added to LUP
- 2021-11-22 12:07:24
- date last changed
- 2023-12-21 13:03:56
@article{057a5846-074c-48d9-9e9a-f491b1dec099, abstract = {{Ruptures to tendons are common and costly, and no clinical consensus exists on the appropriate treatment and rehabilitation regimen to promote their healing as well as full recovery of functionality. Although mechanobiology is known to play an important role in tendon regeneration, the understanding of how mechano-regulated processes affect tendon healing needs further clarification. Many small-animal studies, particularly in rats and mice, have characterized the progression of healing in terms of geometrical, structural, compositional, mechanical, and cellular properties. Some of the properties are also studied under different mechanical loading regimens. The focus of this review is to summarize and generalize the information in the literature regarding spatial and temporal differentiation of tendon properties during rodent tendon healing following full-tendon transection, as well as how this is affected by altered in vivo loading regimens.}}, author = {{Notermans, Thomas and Hammerman, Malin and Eliasson, Pernilla and Isaksson, Hanna}}, issn = {{1473-2262}}, keywords = {{Collagen; extracellular matrix; rupture; achilles tendon; cells; unloading; Immobilization; tissue differentiation; mechanical; heterogeneous}}, language = {{eng}}, month = {{11}}, pages = {{375--391}}, publisher = {{Swiss Society for Biomaterials}}, series = {{European Cells and Materials}}, title = {{Tendon mechanobiology in small animal experiments during post-transection healing}}, url = {{https://lup.lub.lu.se/search/files/167261912/Notermans_eCM_2021.pdf}}, doi = {{10.22203/eCM.v042a23}}, volume = {{42}}, year = {{2021}}, }