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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W; Chu, Audrey Y.; Mahajan, Anubha and Hadley, David, et al. (2017) In PLoS Genetics 13(4).
Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not... (More)

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

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PLoS Genetics
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13
issue
4
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Public Library of Science
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  • scopus:85018450983
  • wos:000402549200002
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1553-7390
DOI
10.1371/journal.pgen.1006528
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English
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yes
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057bd662-bc36-4f95-9de4-51eb11e3461a
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2017-05-19 08:58:09
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2018-10-16 02:48:19
@article{057bd662-bc36-4f95-9de4-51eb11e3461a,
  abstract     = {<p>Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.</p>},
  articleno    = {e1006528},
  author       = {Graff, Mariaelisa and Scott, Robert A. and Justice, Anne E and Young, Kristin L. and Feitosa, Mary F. and Barata, Llilda and Winkler, Thomas W and Chu, Audrey Y. and Mahajan, Anubha and Hadley, David and Xue, Luting and Workalemahu, Tsegaselassie and Heard-Costa, Nancy L. and den Hoed, Marcel and Ahluwalia, Tarunveer S and Qi, Qibin and Ngwa, Julius S and Renström, Frida and Quaye, Lydia and Eicher, John D. and Hayes, James E and Cornelis, Marilyn and Kutalik, Zoltan and Lim, Elise and Luan, Jian’an and Huffman, Jennifer E and Zhang, Weihua and Zhao, Wei and Griffin, Paula J. and Haller, Toomas and Ahmad, Shafqat and Marques-Vidal, Pedro and Bien, Stephanie and Yengo, Loic and Teumer, Alexander and Smith, Albert Vernon and Kumari, Meena and Harder, Marie Neergaard and Justesen, Johanne Marie and Kleber, Marcus E and Hollensted, Mette and Lohman, Kurt and Rivera, Natalia V. and Whitfield, John B and Zhao, Jing Hua and Stringham, Heather M. and Lyytikäinen, Leo-Pekka and Huppertz, Charlotte and Willemsen, Gonneke and Franks, Paul W. and ,  and ,  and , },
  issn         = {1553-7390},
  language     = {eng},
  month        = {04},
  number       = {4},
  publisher    = {Public Library of Science},
  series       = {PLoS Genetics},
  title        = {Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults},
  url          = {http://dx.doi.org/10.1371/journal.pgen.1006528},
  volume       = {13},
  year         = {2017},
}