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The contest between internal and external-beam dosimetry : The Zeno's paradox of Achilles and the tortoise

Cicone, Francesco ; Sjögreen Gleisner, Katarina LU ; Sarnelli, Anna ; Indovina, Luca ; Gear, Jonathan ; Gnesin, Silvano ; Kraeber-Bodéré, Françoise ; Bischof Delaloye, Angelika ; Valentini, Vincenzo and Cremonesi, Marta (2024) In Physica Medica 117.
Abstract

Radionuclide therapy, also called molecular radiotherapy (MRT), has come of age, with several novel radiopharmaceuticals being approved for clinical use or under development in the last decade. External beam radiotherapy (EBRT) is a well-established treatment modality, with about half of all oncologic patients expected to receive at least one external radiation treatment over their disease course. The efficacy and the toxicity of both types of treatment rely on the interaction of radiation with biological tissues. Dosimetry played a fundamental role in the scientific and technological evolution of EBRT, and absorbed doses to the target and to the organs at risk are calculated on a routine basis. In contrast, in MRT the usefulness of... (More)

Radionuclide therapy, also called molecular radiotherapy (MRT), has come of age, with several novel radiopharmaceuticals being approved for clinical use or under development in the last decade. External beam radiotherapy (EBRT) is a well-established treatment modality, with about half of all oncologic patients expected to receive at least one external radiation treatment over their disease course. The efficacy and the toxicity of both types of treatment rely on the interaction of radiation with biological tissues. Dosimetry played a fundamental role in the scientific and technological evolution of EBRT, and absorbed doses to the target and to the organs at risk are calculated on a routine basis. In contrast, in MRT the usefulness of internal dosimetry has long been questioned, and a structured path to include absorbed dose calculation is missing. However, following a similar route of development as EBRT, MRT treatments could probably be optimized in a significant proportion of patients, likely based on dosimetry and radiobiology. In the present paper we describe the differences and the similarities between internal and external-beam dosimetry in the context of radiation treatments, and we retrace the main stages of their development over the last decades.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
External-beam dosimetry, External-beam radiation therapy, Internal dosimetry, Molecular radiotherapy, Radionuclide therapy
in
Physica Medica
volume
117
article number
103188
publisher
ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI
external identifiers
  • pmid:38042710
  • scopus:85179377576
ISSN
1120-1797
DOI
10.1016/j.ejmp.2023.103188
language
English
LU publication?
yes
id
058f2d08-0fb5-4f27-beda-71f9774320ad
date added to LUP
2024-01-11 13:32:47
date last changed
2024-11-09 06:47:49
@article{058f2d08-0fb5-4f27-beda-71f9774320ad,
  abstract     = {{<p>Radionuclide therapy, also called molecular radiotherapy (MRT), has come of age, with several novel radiopharmaceuticals being approved for clinical use or under development in the last decade. External beam radiotherapy (EBRT) is a well-established treatment modality, with about half of all oncologic patients expected to receive at least one external radiation treatment over their disease course. The efficacy and the toxicity of both types of treatment rely on the interaction of radiation with biological tissues. Dosimetry played a fundamental role in the scientific and technological evolution of EBRT, and absorbed doses to the target and to the organs at risk are calculated on a routine basis. In contrast, in MRT the usefulness of internal dosimetry has long been questioned, and a structured path to include absorbed dose calculation is missing. However, following a similar route of development as EBRT, MRT treatments could probably be optimized in a significant proportion of patients, likely based on dosimetry and radiobiology. In the present paper we describe the differences and the similarities between internal and external-beam dosimetry in the context of radiation treatments, and we retrace the main stages of their development over the last decades.</p>}},
  author       = {{Cicone, Francesco and Sjögreen Gleisner, Katarina and Sarnelli, Anna and Indovina, Luca and Gear, Jonathan and Gnesin, Silvano and Kraeber-Bodéré, Françoise and Bischof Delaloye, Angelika and Valentini, Vincenzo and Cremonesi, Marta}},
  issn         = {{1120-1797}},
  keywords     = {{External-beam dosimetry; External-beam radiation therapy; Internal dosimetry; Molecular radiotherapy; Radionuclide therapy}},
  language     = {{eng}},
  publisher    = {{ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI}},
  series       = {{Physica Medica}},
  title        = {{The contest between internal and external-beam dosimetry : The Zeno's paradox of Achilles and the tortoise}},
  url          = {{http://dx.doi.org/10.1016/j.ejmp.2023.103188}},
  doi          = {{10.1016/j.ejmp.2023.103188}},
  volume       = {{117}},
  year         = {{2024}},
}