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Prognostic sub-classifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark's level of invasion. Results of a population-based study from the Swedish Melanoma Register.

Lyth, J; Hansson, J; Ingvar, Christian LU ; Månsson-Brahme, E; Naredi, P; Stierner, U; Wagenius, G and Lindholm, C (2013) In British Journal of Dermatology 168(4). p.779-786
Abstract
Background: Survival and prognostic factors for thin melanomas have been relatively little studied in population-based settings. This patient group account for the majority of melanomas diagnosed in western countries today and better prognostic information is needed. Objective: The aim of this study is to use established prognostic factors such as ulceration, tumour thickness and Clark's level of invasion for risk stratification of T1 cutaneous melanoma. Methods: During 1990-2008, the Swedish Melanoma Register (SMR) included 97% of all melanomas diagnosed in Sweden. All together 13 026 patients with T1 melanomas in clinical stage I were used for estimating melanoma-specific 10- and 15-year mortality rates. Cox regression model was used for... (More)
Background: Survival and prognostic factors for thin melanomas have been relatively little studied in population-based settings. This patient group account for the majority of melanomas diagnosed in western countries today and better prognostic information is needed. Objective: The aim of this study is to use established prognostic factors such as ulceration, tumour thickness and Clark's level of invasion for risk stratification of T1 cutaneous melanoma. Methods: During 1990-2008, the Swedish Melanoma Register (SMR) included 97% of all melanomas diagnosed in Sweden. All together 13 026 patients with T1 melanomas in clinical stage I were used for estimating melanoma-specific 10- and 15-year mortality rates. Cox regression model was used for further survival analysis on 11 165 patients with complete data. Results: Ulceration, tumour thickness and Clark's level of invasion all showed significant independent long-term prognostic information. By combining these factors the patients could be subdivided into three risk groups: a low risk group (67·9% of T1 cases) with a 10-year melanoma-specific mortality rate of 1·5% (1·2-1·9%), an intermediate risk group (28·6% of T1 cases) with a 10-year mortality rate of 6·1% (5·0-7·3%) and a high risk group (3·5% of T1 cases) with a 10-year mortality rate of 15·6% (11·2-21·4%). The high- and intermediate risk group accounted for 66% of melanoma deaths within T1. Conclusions: Using a population-based melanoma register and combining ulceration, tumour thickness and Clark's level of invasion three distinct prognostic subgroups were identified. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
British Journal of Dermatology
volume
168
issue
4
pages
779 - 786
publisher
Wiley-Blackwell
external identifiers
  • wos:000317016100030
  • pmid:23066913
  • scopus:84875449056
ISSN
1365-2133
DOI
10.1111/bjd.12095
language
English
LU publication?
yes
id
05a3312e-f2ce-4ec4-94ef-3e75daa1f27e (old id 3160678)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23066913?dopt=Abstract
date added to LUP
2012-11-01 13:49:49
date last changed
2019-08-28 01:18:42
@article{05a3312e-f2ce-4ec4-94ef-3e75daa1f27e,
  abstract     = {Background: Survival and prognostic factors for thin melanomas have been relatively little studied in population-based settings. This patient group account for the majority of melanomas diagnosed in western countries today and better prognostic information is needed. Objective: The aim of this study is to use established prognostic factors such as ulceration, tumour thickness and Clark's level of invasion for risk stratification of T1 cutaneous melanoma. Methods: During 1990-2008, the Swedish Melanoma Register (SMR) included 97% of all melanomas diagnosed in Sweden. All together 13 026 patients with T1 melanomas in clinical stage I were used for estimating melanoma-specific 10- and 15-year mortality rates. Cox regression model was used for further survival analysis on 11 165 patients with complete data. Results: Ulceration, tumour thickness and Clark's level of invasion all showed significant independent long-term prognostic information. By combining these factors the patients could be subdivided into three risk groups: a low risk group (67·9% of T1 cases) with a 10-year melanoma-specific mortality rate of 1·5% (1·2-1·9%), an intermediate risk group (28·6% of T1 cases) with a 10-year mortality rate of 6·1% (5·0-7·3%) and a high risk group (3·5% of T1 cases) with a 10-year mortality rate of 15·6% (11·2-21·4%). The high- and intermediate risk group accounted for 66% of melanoma deaths within T1. Conclusions: Using a population-based melanoma register and combining ulceration, tumour thickness and Clark's level of invasion three distinct prognostic subgroups were identified.},
  author       = {Lyth, J and Hansson, J and Ingvar, Christian and Månsson-Brahme, E and Naredi, P and Stierner, U and Wagenius, G and Lindholm, C},
  issn         = {1365-2133},
  language     = {eng},
  number       = {4},
  pages        = {779--786},
  publisher    = {Wiley-Blackwell},
  series       = {British Journal of Dermatology},
  title        = {Prognostic sub-classifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark's level of invasion. Results of a population-based study from the Swedish Melanoma Register.},
  url          = {http://dx.doi.org/10.1111/bjd.12095},
  volume       = {168},
  year         = {2013},
}