Prognostic sub-classifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark's level of invasion. Results of a population-based study from the Swedish Melanoma Register.
(2013) In British Journal of Dermatology 168(4). p.779-786- Abstract
- Background: Survival and prognostic factors for thin melanomas have been relatively little studied in population-based settings. This patient group account for the majority of melanomas diagnosed in western countries today and better prognostic information is needed. Objective: The aim of this study is to use established prognostic factors such as ulceration, tumour thickness and Clark's level of invasion for risk stratification of T1 cutaneous melanoma. Methods: During 1990-2008, the Swedish Melanoma Register (SMR) included 97% of all melanomas diagnosed in Sweden. All together 13 026 patients with T1 melanomas in clinical stage I were used for estimating melanoma-specific 10- and 15-year mortality rates. Cox regression model was used for... (More)
- Background: Survival and prognostic factors for thin melanomas have been relatively little studied in population-based settings. This patient group account for the majority of melanomas diagnosed in western countries today and better prognostic information is needed. Objective: The aim of this study is to use established prognostic factors such as ulceration, tumour thickness and Clark's level of invasion for risk stratification of T1 cutaneous melanoma. Methods: During 1990-2008, the Swedish Melanoma Register (SMR) included 97% of all melanomas diagnosed in Sweden. All together 13 026 patients with T1 melanomas in clinical stage I were used for estimating melanoma-specific 10- and 15-year mortality rates. Cox regression model was used for further survival analysis on 11 165 patients with complete data. Results: Ulceration, tumour thickness and Clark's level of invasion all showed significant independent long-term prognostic information. By combining these factors the patients could be subdivided into three risk groups: a low risk group (67·9% of T1 cases) with a 10-year melanoma-specific mortality rate of 1·5% (1·2-1·9%), an intermediate risk group (28·6% of T1 cases) with a 10-year mortality rate of 6·1% (5·0-7·3%) and a high risk group (3·5% of T1 cases) with a 10-year mortality rate of 15·6% (11·2-21·4%). The high- and intermediate risk group accounted for 66% of melanoma deaths within T1. Conclusions: Using a population-based melanoma register and combining ulceration, tumour thickness and Clark's level of invasion three distinct prognostic subgroups were identified. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3160678
- author
- Lyth, J ; Hansson, J ; Ingvar, Christian LU ; Månsson-Brahme, E ; Naredi, P ; Stierner, U ; Wagenius, G and Lindholm, C
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Dermatology
- volume
- 168
- issue
- 4
- pages
- 779 - 786
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000317016100030
- pmid:23066913
- scopus:84875449056
- pmid:23066913
- ISSN
- 1365-2133
- DOI
- 10.1111/bjd.12095
- language
- English
- LU publication?
- yes
- id
- 05a3312e-f2ce-4ec4-94ef-3e75daa1f27e (old id 3160678)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23066913?dopt=Abstract
- date added to LUP
- 2016-04-01 10:23:49
- date last changed
- 2022-04-27 21:40:44
@article{05a3312e-f2ce-4ec4-94ef-3e75daa1f27e,
abstract = {{Background: Survival and prognostic factors for thin melanomas have been relatively little studied in population-based settings. This patient group account for the majority of melanomas diagnosed in western countries today and better prognostic information is needed. Objective: The aim of this study is to use established prognostic factors such as ulceration, tumour thickness and Clark's level of invasion for risk stratification of T1 cutaneous melanoma. Methods: During 1990-2008, the Swedish Melanoma Register (SMR) included 97% of all melanomas diagnosed in Sweden. All together 13 026 patients with T1 melanomas in clinical stage I were used for estimating melanoma-specific 10- and 15-year mortality rates. Cox regression model was used for further survival analysis on 11 165 patients with complete data. Results: Ulceration, tumour thickness and Clark's level of invasion all showed significant independent long-term prognostic information. By combining these factors the patients could be subdivided into three risk groups: a low risk group (67·9% of T1 cases) with a 10-year melanoma-specific mortality rate of 1·5% (1·2-1·9%), an intermediate risk group (28·6% of T1 cases) with a 10-year mortality rate of 6·1% (5·0-7·3%) and a high risk group (3·5% of T1 cases) with a 10-year mortality rate of 15·6% (11·2-21·4%). The high- and intermediate risk group accounted for 66% of melanoma deaths within T1. Conclusions: Using a population-based melanoma register and combining ulceration, tumour thickness and Clark's level of invasion three distinct prognostic subgroups were identified.}},
author = {{Lyth, J and Hansson, J and Ingvar, Christian and Månsson-Brahme, E and Naredi, P and Stierner, U and Wagenius, G and Lindholm, C}},
issn = {{1365-2133}},
language = {{eng}},
number = {{4}},
pages = {{779--786}},
publisher = {{Wiley-Blackwell}},
series = {{British Journal of Dermatology}},
title = {{Prognostic sub-classifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark's level of invasion. Results of a population-based study from the Swedish Melanoma Register.}},
url = {{http://dx.doi.org/10.1111/bjd.12095}},
doi = {{10.1111/bjd.12095}},
volume = {{168}},
year = {{2013}},
}