Analysis of 5-hydroxy-N-methyl-2-pyrrolidone and 2-hydroxy-N-methylsuccinimide in plasma
(1997) In Chromatographia 46(3-4). p.141-144- Abstract
- A method for the determination of 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP) and 2-hydroxy-N-methylsuccinimide (2-HMSI) in plasma was developed. 5-HNMP and 2-HMSI are metabolites to the widely used organic solvent N-methyl-2pyrrolidone (NMP). The 5-HNMP and 2-HMSI were purified from plasma by C8 solid phase extraction, derivatised by bistrimethylsilyl trifluoroacetamid, and analysed by gas chromatography with mass spectrometric detection. For 5-HNMP, the precision was 2–7 % (120 and 780 ng mL−1) and the detection limit was 6 ng mL−1 (m/z 98). For 2-HMSI, the precision was 2–9 % (160 and 1000 ng mL−1) and the detection limit was 4 ng mL−1 (m/z 144). The method is applicable for analysis of plasma samples from workers exposed to NMP.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111900
- author
- Jonsson, B A G and Åkesson, Bengt LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Gas chromatography-mass spectrometry, Biological monitoring, 5-hydroxy-N-methyl-2-pyrrolidone, 2-hydroxy-N-methylsuccinimide, Plasma samples
- in
- Chromatographia
- volume
- 46
- issue
- 3-4
- pages
- 141 - 144
- publisher
- Vieweg Verlag
- external identifiers
-
- scopus:0030810963
- ISSN
- 0009-5893
- DOI
- 10.1007/BF02495324
- language
- English
- LU publication?
- yes
- id
- 05abd1f8-9cb5-40cc-b54e-f4330581eb87 (old id 1111900)
- date added to LUP
- 2016-04-01 17:15:24
- date last changed
- 2022-04-15 18:15:47
@article{05abd1f8-9cb5-40cc-b54e-f4330581eb87, abstract = {{A method for the determination of 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP) and 2-hydroxy-N-methylsuccinimide (2-HMSI) in plasma was developed. 5-HNMP and 2-HMSI are metabolites to the widely used organic solvent N-methyl-2pyrrolidone (NMP). The 5-HNMP and 2-HMSI were purified from plasma by C8 solid phase extraction, derivatised by bistrimethylsilyl trifluoroacetamid, and analysed by gas chromatography with mass spectrometric detection. For 5-HNMP, the precision was 2–7 % (120 and 780 ng mL−1) and the detection limit was 6 ng mL−1 (m/z 98). For 2-HMSI, the precision was 2–9 % (160 and 1000 ng mL−1) and the detection limit was 4 ng mL−1 (m/z 144). The method is applicable for analysis of plasma samples from workers exposed to NMP.}}, author = {{Jonsson, B A G and Åkesson, Bengt}}, issn = {{0009-5893}}, keywords = {{Gas chromatography-mass spectrometry; Biological monitoring; 5-hydroxy-N-methyl-2-pyrrolidone; 2-hydroxy-N-methylsuccinimide; Plasma samples}}, language = {{eng}}, number = {{3-4}}, pages = {{141--144}}, publisher = {{Vieweg Verlag}}, series = {{Chromatographia}}, title = {{Analysis of 5-hydroxy-N-methyl-2-pyrrolidone and 2-hydroxy-N-methylsuccinimide in plasma}}, url = {{http://dx.doi.org/10.1007/BF02495324}}, doi = {{10.1007/BF02495324}}, volume = {{46}}, year = {{1997}}, }