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A hidden cost of migration? Innate immune function versus antioxidant defense

Eikenaar, Cas; Isaksson, Caroline LU and Hegemann, Arne LU (2018) In Ecology and Evolution
Abstract

Migration is energetically demanding and physiologically challenging. Migrating birds, for example, need to boost their antioxidant defenses to defeat the pro-oxidants produced during high energetic activity. The enhanced antioxidant defense possibly withdraws limited resources (e.g., energy or micronutrients) from other physiological functions, such as immune defense. Such a trade-off might not occur outside the migration seasons or in resident individuals. Here, we investigate whether there is a negative relationship between innate immune function and antioxidant defense by sampling both migrating and resident blackbirds (Turdus merula) at the same location during the same period of the annual cycle. We show that in migrating... (More)

Migration is energetically demanding and physiologically challenging. Migrating birds, for example, need to boost their antioxidant defenses to defeat the pro-oxidants produced during high energetic activity. The enhanced antioxidant defense possibly withdraws limited resources (e.g., energy or micronutrients) from other physiological functions, such as immune defense. Such a trade-off might not occur outside the migration seasons or in resident individuals. Here, we investigate whether there is a negative relationship between innate immune function and antioxidant defense by sampling both migrating and resident blackbirds (Turdus merula) at the same location during the same period of the annual cycle. We show that in migrating blackbirds microbial killing capacity (BKA), an integrative measure of baseline innate immune function was negatively correlated with total nonenzymatic antioxidant capacity. In contrast, in resident conspecifics, sampled at the same time and location, these two physiological measures were not correlated. This suggests that migrating birds trade off innate immune function and antioxidant defense. Furthermore, and likely a consequence of this trade-off, in migrant blackbirds BKA was positively correlated with oxidative damage to lipids. In resident blackbirds BKA and degree of lipid oxidation were uncorrelated. The mechanism and currencies of the supposed trade-off are currently unknown, but energetic investments or micronutrients are likely candidates. Future experimental studies could provide more conclusive evidence for this trade-off; yet, our results open up a new level of thinking about the physiological costs of migration.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Avian migration, Ecophysiology, Immunity, Oxidative stress, Trade-off
in
Ecology and Evolution
publisher
Wiley-Blackwell
external identifiers
  • scopus:85041600061
ISSN
2045-7758
DOI
10.1002/ece3.3756
language
English
LU publication?
yes
id
05d7b52c-7e80-4aff-8d58-ce220736ce37
date added to LUP
2018-02-21 14:19:47
date last changed
2018-11-04 04:35:30
@article{05d7b52c-7e80-4aff-8d58-ce220736ce37,
  abstract     = {<p>Migration is energetically demanding and physiologically challenging. Migrating birds, for example, need to boost their antioxidant defenses to defeat the pro-oxidants produced during high energetic activity. The enhanced antioxidant defense possibly withdraws limited resources (e.g., energy or micronutrients) from other physiological functions, such as immune defense. Such a trade-off might not occur outside the migration seasons or in resident individuals. Here, we investigate whether there is a negative relationship between innate immune function and antioxidant defense by sampling both migrating and resident blackbirds (Turdus merula) at the same location during the same period of the annual cycle. We show that in migrating blackbirds microbial killing capacity (BKA), an integrative measure of baseline innate immune function was negatively correlated with total nonenzymatic antioxidant capacity. In contrast, in resident conspecifics, sampled at the same time and location, these two physiological measures were not correlated. This suggests that migrating birds trade off innate immune function and antioxidant defense. Furthermore, and likely a consequence of this trade-off, in migrant blackbirds BKA was positively correlated with oxidative damage to lipids. In resident blackbirds BKA and degree of lipid oxidation were uncorrelated. The mechanism and currencies of the supposed trade-off are currently unknown, but energetic investments or micronutrients are likely candidates. Future experimental studies could provide more conclusive evidence for this trade-off; yet, our results open up a new level of thinking about the physiological costs of migration.</p>},
  author       = {Eikenaar, Cas and Isaksson, Caroline and Hegemann, Arne},
  issn         = {2045-7758},
  keyword      = {Avian migration,Ecophysiology,Immunity,Oxidative stress,Trade-off},
  language     = {eng},
  month        = {02},
  publisher    = {Wiley-Blackwell},
  series       = {Ecology and Evolution},
  title        = {A hidden cost of migration? Innate immune function versus antioxidant defense},
  url          = {http://dx.doi.org/10.1002/ece3.3756},
  year         = {2018},
}