Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns
(2023) In Alzheimer's and Dementia- Abstract
INTRODUCTION: We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups. METHODS: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory. RESULTS: There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language,... (More)
INTRODUCTION: We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups. METHODS: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory. RESULTS: There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive, and posterior lower GMV for AD-Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD-Language group than any other group (p = 1.15 × 10−10). For overlap between imaging-defined and cognitively defined subgroups, AD-Memory matched up with an imaging-defined limbic predominant group. DISCUSSION: MRI findings differ across cognitively defined AD subgroups.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- Alzheimer's disease dementia, asymmetry, atrophy, cognitive heterogeneity, neurodegeneration, subgroups
- in
- Alzheimer's and Dementia
- publisher
- Wiley
- external identifiers
-
- pmid:38093529
- scopus:85179679940
- ISSN
- 1552-5260
- DOI
- 10.1002/alz.13567
- language
- English
- LU publication?
- yes
- id
- 05ebfc87-e992-4562-82ed-0e1e03ad7b14
- date added to LUP
- 2024-01-09 14:46:36
- date last changed
- 2024-04-24 10:42:01
@article{05ebfc87-e992-4562-82ed-0e1e03ad7b14,
abstract = {{<p>INTRODUCTION: We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups. METHODS: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory. RESULTS: There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive, and posterior lower GMV for AD-Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD-Language group than any other group (p = 1.15 × 10<sup>−10</sup>). For overlap between imaging-defined and cognitively defined subgroups, AD-Memory matched up with an imaging-defined limbic predominant group. DISCUSSION: MRI findings differ across cognitively defined AD subgroups.</p>}},
author = {{Crane, Paul K. and Groot, Colin and Ossenkoppele, Rik and Mukherjee, Shubhabrata and Choi, Seo Eun and Lee, Michael and Scollard, Phoebe and Gibbons, Laura E. and Sanders, R. Elizabeth and Trittschuh, Emily and Saykin, Andrew J. and Mez, Jesse and Nakano, Connie and Donald, Christine Mac and Sohi, Harkirat and Risacher, Shannon}},
issn = {{1552-5260}},
keywords = {{Alzheimer's disease dementia; asymmetry; atrophy; cognitive heterogeneity; neurodegeneration; subgroups}},
language = {{eng}},
publisher = {{Wiley}},
series = {{Alzheimer's and Dementia}},
title = {{Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns}},
url = {{http://dx.doi.org/10.1002/alz.13567}},
doi = {{10.1002/alz.13567}},
year = {{2023}},
}