Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene
(2005) In Biochemical and Biophysical Research Communications 329(4). p.1193-1199- Abstract
- We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells. (c) 2005 Elsevier Inc. All rights reserved.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/151526
- author
- Zierhut, B ; Daneva, T ; Gartner, W ; Brunnmaier, B ; Mineva, I ; Berggård, Tord LU and Wagner, L
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemical and Biophysical Research Communications
- volume
- 329
- issue
- 4
- pages
- 1193 - 1199
- publisher
- Elsevier
- external identifiers
-
- pmid:15766553
- wos:000227886300004
- scopus:17644408724
- ISSN
- 1090-2104
- DOI
- 10.1016/j.bbrc.2005.02.093
- language
- English
- LU publication?
- yes
- id
- 05f8c375-c177-45ed-8e14-83e7089baac6 (old id 151526)
- date added to LUP
- 2016-04-01 16:59:49
- date last changed
- 2022-01-28 23:39:16
@article{05f8c375-c177-45ed-8e14-83e7089baac6, abstract = {{We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells. (c) 2005 Elsevier Inc. All rights reserved.}}, author = {{Zierhut, B and Daneva, T and Gartner, W and Brunnmaier, B and Mineva, I and Berggård, Tord and Wagner, L}}, issn = {{1090-2104}}, language = {{eng}}, number = {{4}}, pages = {{1193--1199}}, publisher = {{Elsevier}}, series = {{Biochemical and Biophysical Research Communications}}, title = {{Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene}}, url = {{http://dx.doi.org/10.1016/j.bbrc.2005.02.093}}, doi = {{10.1016/j.bbrc.2005.02.093}}, volume = {{329}}, year = {{2005}}, }