Advanced

High androgen levels protect against hypothyroidism

Schmidt, Johanna; Dahlgren, Eva; Bryman, Inger; Berntorp, Kerstin LU ; Trimpou, Penelope; Wilhelmsen, Lars and Landin-Wilhelmsen, Kerstin (2017) In Acta Obstetricia et Gynecologica Scandinavica 96(1). p.39-46
Abstract

Introduction: Hypothyroidism is a common disorder, appearing mainly in women although less frequently found in women with polycystic ovary syndrome (PCOS). The objective was to test the hypothesis that hyperandrogenism might protect against hypothyroidism. Material and methods: The data from three prospective follow-up studies (up to 21 years) and one register study were compared: women with PCOS (Rotterdam criteria), n = 25, women with Turner syndrome, n = 217, a random population sample of women, n = 315, and men, n = 95 (the WHO MONICA study). Findings were to be verified or rejected in all females, n = 553 716, from the same region. The proportion of hypothyroidism was calculated and thyroid peroxidase antibodies (TPO) in serum were... (More)

Introduction: Hypothyroidism is a common disorder, appearing mainly in women although less frequently found in women with polycystic ovary syndrome (PCOS). The objective was to test the hypothesis that hyperandrogenism might protect against hypothyroidism. Material and methods: The data from three prospective follow-up studies (up to 21 years) and one register study were compared: women with PCOS (Rotterdam criteria), n = 25, women with Turner syndrome, n = 217, a random population sample of women, n = 315, and men, n = 95 (the WHO MONICA study). Findings were to be verified or rejected in all females, n = 553 716, from the same region. The proportion of hypothyroidism was calculated and thyroid peroxidase antibodies (TPO) in serum were measured. Results: Hypothyroidism at >50 years of age was found in 8% of women with PCOS, 4% in men (PCOS vs. men; ns), 43% of women with Turner syndrome, irrespective of karyotype (p < 0.001 vs. PCOS), and in 17% of postmenopausal women in the population (p < 0.01 vs. PCOS). Elevated TPO were similar in PCOS and women and men in the population but higher in Turner syndrome. Hypothyroidism increased with age in all groups except PCOS women and men. In the register study, hypothyroidism was less common in women with PCOS >25 years (5.5%) than in women without PCOS (6.8%) from the same region (p < 0.01). Conclusions: Hypothyroidism was less frequently seen in women with PCOS and in men compared with women in the general population and among women with Turner syndrome. This was not explained by altered autoimmunity or the Y-chromosome. Androgens seem to protect against hypothyroidism.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Androgens, hypothyroidism, polycystic ovary syndrome, Turner syndrome
in
Acta Obstetricia et Gynecologica Scandinavica
volume
96
issue
1
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85006725472
  • wos:000391980100005
ISSN
0001-6349
DOI
10.1111/aogs.13054
language
English
LU publication?
yes
id
0603de3e-3afa-4839-9974-dbacc01cafa2
date added to LUP
2017-01-16 10:08:28
date last changed
2018-01-07 11:45:13
@article{0603de3e-3afa-4839-9974-dbacc01cafa2,
  abstract     = {<p>Introduction: Hypothyroidism is a common disorder, appearing mainly in women although less frequently found in women with polycystic ovary syndrome (PCOS). The objective was to test the hypothesis that hyperandrogenism might protect against hypothyroidism. Material and methods: The data from three prospective follow-up studies (up to 21 years) and one register study were compared: women with PCOS (Rotterdam criteria), n = 25, women with Turner syndrome, n = 217, a random population sample of women, n = 315, and men, n = 95 (the WHO MONICA study). Findings were to be verified or rejected in all females, n = 553 716, from the same region. The proportion of hypothyroidism was calculated and thyroid peroxidase antibodies (TPO) in serum were measured. Results: Hypothyroidism at &gt;50 years of age was found in 8% of women with PCOS, 4% in men (PCOS vs. men; ns), 43% of women with Turner syndrome, irrespective of karyotype (p &lt; 0.001 vs. PCOS), and in 17% of postmenopausal women in the population (p &lt; 0.01 vs. PCOS). Elevated TPO were similar in PCOS and women and men in the population but higher in Turner syndrome. Hypothyroidism increased with age in all groups except PCOS women and men. In the register study, hypothyroidism was less common in women with PCOS &gt;25 years (5.5%) than in women without PCOS (6.8%) from the same region (p &lt; 0.01). Conclusions: Hypothyroidism was less frequently seen in women with PCOS and in men compared with women in the general population and among women with Turner syndrome. This was not explained by altered autoimmunity or the Y-chromosome. Androgens seem to protect against hypothyroidism.</p>},
  author       = {Schmidt, Johanna and Dahlgren, Eva and Bryman, Inger and Berntorp, Kerstin and Trimpou, Penelope and Wilhelmsen, Lars and Landin-Wilhelmsen, Kerstin},
  issn         = {0001-6349},
  keyword      = {Androgens,hypothyroidism,polycystic ovary syndrome,Turner syndrome},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {39--46},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {High androgen levels protect against hypothyroidism},
  url          = {http://dx.doi.org/10.1111/aogs.13054},
  volume       = {96},
  year         = {2017},
}