Human intestinal B cells in inflammatory diseases
Spencer, Jo and Bemark, Mats LU
(2023)
In Nature Reviews Gastroenterology and Hepatology
20(4).
p.254-265
- Abstract
The intestinal lumen contains an abundance of bacteria, viruses and fungi alongside ingested material that shape the chronically active intestinal immune system from early life to maintain the integrity of the gut epithelial barrier. In health, the response is intricately balanced to provide active protection against pathogen invasion whilst tolerating food and avoiding inflammation. B cells are central to achieving this protection. Their activation and maturation generates the body's largest plasma cell population that secretes IgA, and the niches they provide support systemic immune cell specialization. For example, the gut supports the development and maturation of a splenic B cell subset - the marginal zone B cells. In addition,... (More)
The intestinal lumen contains an abundance of bacteria, viruses and fungi alongside ingested material that shape the chronically active intestinal immune system from early life to maintain the integrity of the gut epithelial barrier. In health, the response is intricately balanced to provide active protection against pathogen invasion whilst tolerating food and avoiding inflammation. B cells are central to achieving this protection. Their activation and maturation generates the body's largest plasma cell population that secretes IgA, and the niches they provide support systemic immune cell specialization. For example, the gut supports the development and maturation of a splenic B cell subset - the marginal zone B cells. In addition, cells such as the T follicular helper cells, which are enriched in many autoinflammatory diseases, are intrinsically associated with the germinal centre microenvironment that is more abundant in the gut than in any other tissue in health. In this Review, we discuss intestinal B cells and their role when a loss of homeostasis results in intestinal and systemic inflammatory diseases.
(Less)
- author
- Spencer, Jo
and Bemark, Mats
LU
- publishing date
- 2023-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Intestines, B-Lymphocytes, Gastrointestinal Tract, Inflammation, Intestinal Mucosa
- in
- Nature Reviews Gastroenterology and Hepatology
- volume
- 20
- issue
- 4
- pages
- 12 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85149043778
- pmid:36849542
- ISSN
- 1759-5045
- DOI
- 10.1038/s41575-023-00755-6
- language
- English
- LU publication?
- no
- additional info
- © 2023. Springer Nature Limited.
- id
- 0605de83-fa1a-499a-8212-9437411c773d
- date added to LUP
- 2023-11-16 12:38:23
- date last changed
- 2024-04-14 17:42:07
@article{0605de83-fa1a-499a-8212-9437411c773d,
abstract = {{<p>The intestinal lumen contains an abundance of bacteria, viruses and fungi alongside ingested material that shape the chronically active intestinal immune system from early life to maintain the integrity of the gut epithelial barrier. In health, the response is intricately balanced to provide active protection against pathogen invasion whilst tolerating food and avoiding inflammation. B cells are central to achieving this protection. Their activation and maturation generates the body's largest plasma cell population that secretes IgA, and the niches they provide support systemic immune cell specialization. For example, the gut supports the development and maturation of a splenic B cell subset - the marginal zone B cells. In addition, cells such as the T follicular helper cells, which are enriched in many autoinflammatory diseases, are intrinsically associated with the germinal centre microenvironment that is more abundant in the gut than in any other tissue in health. In this Review, we discuss intestinal B cells and their role when a loss of homeostasis results in intestinal and systemic inflammatory diseases.</p>}},
author = {{Spencer, Jo and Bemark, Mats}},
issn = {{1759-5045}},
keywords = {{Humans; Intestines; B-Lymphocytes; Gastrointestinal Tract; Inflammation; Intestinal Mucosa}},
language = {{eng}},
number = {{4}},
pages = {{254--265}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews Gastroenterology and Hepatology}},
title = {{Human intestinal B cells in inflammatory diseases}},
url = {{http://dx.doi.org/10.1038/s41575-023-00755-6}},
doi = {{10.1038/s41575-023-00755-6}},
volume = {{20}},
year = {{2023}},
}