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Blood pressure in 6-year-old children born extremely preterm

Bonamy, Anna Karin Edstedt; Mohlkert, Lilly Ann; Hallberg, Jenny; Liuba, Petru LU ; Fellman, Vineta LU ; Domellöf, Magnus and Norman, Mikael (2017) In Journal of the American Heart Association 6(8).
Abstract

Background--Advances in perinatal medicine have increased infant survival after very preterm birth. Although this progress is welcome, there is increasing concern that preterm birth is an emerging risk factor for hypertension at young age, with implications for the lifetime risk of cardiovascular disease. Methods and Results--We measured casual blood pressures (BPs) in a population-based cohort of 6-year-old survivors of extremely preterm birth (< 27 gestational weeks; n=171) and in age- and sex-matched controls born at term (n=172). Measured BP did not differ, but sex, age-, and height-adjusted median z scores were 0.14 SD higher (P=0.02) for systolic BP and 0.10 SD higher (P=0.01) for diastolic BP in children born extremely preterm... (More)

Background--Advances in perinatal medicine have increased infant survival after very preterm birth. Although this progress is welcome, there is increasing concern that preterm birth is an emerging risk factor for hypertension at young age, with implications for the lifetime risk of cardiovascular disease. Methods and Results--We measured casual blood pressures (BPs) in a population-based cohort of 6-year-old survivors of extremely preterm birth (< 27 gestational weeks; n=171) and in age- and sex-matched controls born at term (n=172). Measured BP did not differ, but sex, age-, and height-adjusted median z scores were 0.14 SD higher (P=0.02) for systolic BP and 0.10 SD higher (P=0.01) for diastolic BP in children born extremely preterm than in controls. Among children born extremely preterm, shorter gestation, higher body mass index, and higher heart rate at follow-up were all independently associated with higher BP at 6 years of age, whereas preeclampsia, smoking in pregnancy, neonatal morbidity, and perinatal corticosteroid therapy were not. In multivariate regression analyses, systolic BP decreased by 0.10 SD (P=0.08) and diastolic BP by 0.09 SD (P=0.02) for each weeklonger gestation. Conclusions--Six-year-old children born extremely preterm have normal but slightly higher BP than their peers born at term. Although this finding is reassuring for children born preterm and their families, follow-up at older age is warranted.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Follow-up study, Hypertension, Pediatrics, Preterm birth
in
Journal of the American Heart Association
volume
6
issue
8
publisher
Wiley-Blackwell
external identifiers
  • scopus:85030663120
ISSN
2047-9980
DOI
10.1161/JAHA.117.005858
language
English
LU publication?
yes
id
063c9a98-eecb-4cd8-8a45-be34fea96ffc
date added to LUP
2017-11-03 08:47:35
date last changed
2018-04-15 04:48:27
@article{063c9a98-eecb-4cd8-8a45-be34fea96ffc,
  abstract     = {<p>Background--Advances in perinatal medicine have increased infant survival after very preterm birth. Although this progress is welcome, there is increasing concern that preterm birth is an emerging risk factor for hypertension at young age, with implications for the lifetime risk of cardiovascular disease. Methods and Results--We measured casual blood pressures (BPs) in a population-based cohort of 6-year-old survivors of extremely preterm birth (&lt; 27 gestational weeks; n=171) and in age- and sex-matched controls born at term (n=172). Measured BP did not differ, but sex, age-, and height-adjusted median z scores were 0.14 SD higher (P=0.02) for systolic BP and 0.10 SD higher (P=0.01) for diastolic BP in children born extremely preterm than in controls. Among children born extremely preterm, shorter gestation, higher body mass index, and higher heart rate at follow-up were all independently associated with higher BP at 6 years of age, whereas preeclampsia, smoking in pregnancy, neonatal morbidity, and perinatal corticosteroid therapy were not. In multivariate regression analyses, systolic BP decreased by 0.10 SD (P=0.08) and diastolic BP by 0.09 SD (P=0.02) for each weeklonger gestation. Conclusions--Six-year-old children born extremely preterm have normal but slightly higher BP than their peers born at term. Although this finding is reassuring for children born preterm and their families, follow-up at older age is warranted.</p>},
  articleno    = {e005858},
  author       = {Bonamy, Anna Karin Edstedt and Mohlkert, Lilly Ann and Hallberg, Jenny and Liuba, Petru and Fellman, Vineta and Domellöf, Magnus and Norman, Mikael},
  issn         = {2047-9980},
  keyword      = {Follow-up study,Hypertension,Pediatrics,Preterm birth},
  language     = {eng},
  month        = {08},
  number       = {8},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of the American Heart Association},
  title        = {Blood pressure in 6-year-old children born extremely preterm},
  url          = {http://dx.doi.org/10.1161/JAHA.117.005858},
  volume       = {6},
  year         = {2017},
}