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Abnormal auditory brainstem response in the pons region in youth with autism

Claesdotter-Knutsson, Emma LU ; Åkerlund, Sofia LU ; Cervin, Matti LU ; Råstam, Maria LU and Lindvall, Magnus LU (2019) In Neurology Psychiatry and Brain Research 32. p.122-125
Abstract

Purpose of the article: Autism spectrum disorder (ASD)is an impairing neurodevelopmental disorder with an unknown etiology. The present study aims to investigate if the auditory brainstem response (ABR)to complex stimuli in children and adolescents diagnosed with ASD can be a possible objective biomarker in autism. Materials and methods: The ABR of 39 youth with ASD (7–18 years)were compared to the ABR of 34 typically developed youth (TD). The ABR consists of seven positive peaks (waves I–VII)that occur during 10 Ms following a sound stimulus. Results: The amplitude of wave III (region 2.5–4.0 Ms)was higher in the ASD group compared to the TD group. The TD males showed a significant lower degree of correlation, between left and right... (More)

Purpose of the article: Autism spectrum disorder (ASD)is an impairing neurodevelopmental disorder with an unknown etiology. The present study aims to investigate if the auditory brainstem response (ABR)to complex stimuli in children and adolescents diagnosed with ASD can be a possible objective biomarker in autism. Materials and methods: The ABR of 39 youth with ASD (7–18 years)were compared to the ABR of 34 typically developed youth (TD). The ABR consists of seven positive peaks (waves I–VII)that occur during 10 Ms following a sound stimulus. Results: The amplitude of wave III (region 2.5–4.0 Ms)was higher in the ASD group compared to the TD group. The TD males showed a significant lower degree of correlation, between left and right ear compared to the ASD groups and the TD females. Conclusions: Altered auditory processing was evident in the pons region of the brainstem for the ASD group when compared to the TD group. Implications of the findings are discussed in relation to the neurobiology and assessment of autism spectrum disorder in youth.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ABR, Adolescents, ASD, Biomarker, Children
in
Neurology Psychiatry and Brain Research
volume
32
pages
4 pages
publisher
Elsevier GmbH
external identifiers
  • scopus:85066112116
ISSN
0941-9500
DOI
10.1016/j.npbr.2019.03.009
language
English
LU publication?
yes
id
0672b35b-a545-46db-9240-844b74535d5d
date added to LUP
2019-06-11 12:11:43
date last changed
2020-01-13 01:59:09
@article{0672b35b-a545-46db-9240-844b74535d5d,
  abstract     = {<p>Purpose of the article: Autism spectrum disorder (ASD)is an impairing neurodevelopmental disorder with an unknown etiology. The present study aims to investigate if the auditory brainstem response (ABR)to complex stimuli in children and adolescents diagnosed with ASD can be a possible objective biomarker in autism. Materials and methods: The ABR of 39 youth with ASD (7–18 years)were compared to the ABR of 34 typically developed youth (TD). The ABR consists of seven positive peaks (waves I–VII)that occur during 10 Ms following a sound stimulus. Results: The amplitude of wave III (region 2.5–4.0 Ms)was higher in the ASD group compared to the TD group. The TD males showed a significant lower degree of correlation, between left and right ear compared to the ASD groups and the TD females. Conclusions: Altered auditory processing was evident in the pons region of the brainstem for the ASD group when compared to the TD group. Implications of the findings are discussed in relation to the neurobiology and assessment of autism spectrum disorder in youth.</p>},
  author       = {Claesdotter-Knutsson, Emma and Åkerlund, Sofia and Cervin, Matti and Råstam, Maria and Lindvall, Magnus},
  issn         = {0941-9500},
  language     = {eng},
  pages        = {122--125},
  publisher    = {Elsevier GmbH},
  series       = {Neurology Psychiatry and Brain Research},
  title        = {Abnormal auditory brainstem response in the pons region in youth with autism},
  url          = {http://dx.doi.org/10.1016/j.npbr.2019.03.009},
  doi          = {10.1016/j.npbr.2019.03.009},
  volume       = {32},
  year         = {2019},
}