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Prehospital administration of P2Y12 inhibitors and early coronary reperfusion in primary PCI : an observational comparative study

De Backer, Ole ; Ratcovich, Hanna ; Biasco, Luigi ; Pedersen, Frants ; Helqvist, Steffen ; Saunamäki, Kari ; Tilsted, Hans-Henrik ; Clemmensen, Peter ; Olivecrona, Goran LU and Kelbaek, Henning , et al. (2015) In Thrombosis and Haemostasis 114(3). p.31-623
Abstract

The newer oral P2Y12 inhibitors prasugrel and ticagrelor have been reported to be more potent and faster-acting antiplatelet agents than clopidogrel. This study aimed to investigate whether prehospital loading with prasugrel or ticagrelor improves early coronary reperfusion as compared to prehospital loading with clopidogrel in a real-world ST-elevation myocardial infarction (STEMI) setting. Over a 70-month period, 3497 patients with on-going STEMI of less than 6 hours and without cardiac arrest or cardiogenic shock underwent primary percutaneous coronary intervention (PPCI) at our centre. The primary endpoint of this study was the proportion of patients who did not meet the criteria for TIMI (Thrombolysis In Myocardial Infarction) flow... (More)

The newer oral P2Y12 inhibitors prasugrel and ticagrelor have been reported to be more potent and faster-acting antiplatelet agents than clopidogrel. This study aimed to investigate whether prehospital loading with prasugrel or ticagrelor improves early coronary reperfusion as compared to prehospital loading with clopidogrel in a real-world ST-elevation myocardial infarction (STEMI) setting. Over a 70-month period, 3497 patients with on-going STEMI of less than 6 hours and without cardiac arrest or cardiogenic shock underwent primary percutaneous coronary intervention (PPCI) at our centre. The primary endpoint of this study was the proportion of patients who did not meet the criteria for TIMI (Thrombolysis In Myocardial Infarction) flow grade 3 in the infarct-related artery at initial angiography before PPCI. Prehospital loading with prasugrel (n = 883) or ticagrelor (n = 491) did not significantly improve coronary reperfusion as compared to prehospital loading with clopidogrel (n = 1,532) - a TIMI-flow 3 at initial angiography was absent in 71.7 %, 69.0 % and 71.5 % of patients, respectively. Major adverse cardiac event (MACE) rates were low at 30 days (3.4 % to 4.0 %) and did not significantly differ between the different P2Y12 inhibitor regimens. In conclusion, this large observational, non-randomised study is the first to show that prehospital loading with the newer P2Y12 inhibitors does not improve early coronary reperfusion as compared to prehospital loading with clopidogrel in a PPCI cohort excluding cardiac arrest and cardiogenic shock.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenosine/administration & dosage, Aged, Clopidogrel, Coronary Angiography, Coronary Circulation/drug effects, Drug Administration Schedule, Emergency Medical Services, Female, Humans, Male, Middle Aged, Myocardial Infarction/blood, Percutaneous Coronary Intervention/adverse effects, Platelet Aggregation Inhibitors/administration & dosage, Prasugrel Hydrochloride/administration & dosage, Purinergic P2Y Receptor Antagonists/administration & dosage, Ticagrelor, Ticlopidine/administration & dosage, Time Factors, Treatment Outcome
in
Thrombosis and Haemostasis
volume
114
issue
3
pages
31 - 623
publisher
Schattauer GmbH
external identifiers
  • scopus:84940652937
  • pmid:25994355
ISSN
0340-6245
DOI
10.1160/TH15-01-0026
language
English
LU publication?
no
id
0675b413-9a7d-4259-8b6a-9c12283721c6
date added to LUP
2021-02-02 11:09:24
date last changed
2024-01-18 01:17:28
@article{0675b413-9a7d-4259-8b6a-9c12283721c6,
  abstract     = {{<p>The newer oral P2Y12 inhibitors prasugrel and ticagrelor have been reported to be more potent and faster-acting antiplatelet agents than clopidogrel. This study aimed to investigate whether prehospital loading with prasugrel or ticagrelor improves early coronary reperfusion as compared to prehospital loading with clopidogrel in a real-world ST-elevation myocardial infarction (STEMI) setting. Over a 70-month period, 3497 patients with on-going STEMI of less than 6 hours and without cardiac arrest or cardiogenic shock underwent primary percutaneous coronary intervention (PPCI) at our centre. The primary endpoint of this study was the proportion of patients who did not meet the criteria for TIMI (Thrombolysis In Myocardial Infarction) flow grade 3 in the infarct-related artery at initial angiography before PPCI. Prehospital loading with prasugrel (n = 883) or ticagrelor (n = 491) did not significantly improve coronary reperfusion as compared to prehospital loading with clopidogrel (n = 1,532) - a TIMI-flow 3 at initial angiography was absent in 71.7 %, 69.0 % and 71.5 % of patients, respectively. Major adverse cardiac event (MACE) rates were low at 30 days (3.4 % to 4.0 %) and did not significantly differ between the different P2Y12 inhibitor regimens. In conclusion, this large observational, non-randomised study is the first to show that prehospital loading with the newer P2Y12 inhibitors does not improve early coronary reperfusion as compared to prehospital loading with clopidogrel in a PPCI cohort excluding cardiac arrest and cardiogenic shock. </p>}},
  author       = {{De Backer, Ole and Ratcovich, Hanna and Biasco, Luigi and Pedersen, Frants and Helqvist, Steffen and Saunamäki, Kari and Tilsted, Hans-Henrik and Clemmensen, Peter and Olivecrona, Goran and Kelbaek, Henning and Jørgensen, Erik and Engstrøm, Thomas and Holmvang, Lene}},
  issn         = {{0340-6245}},
  keywords     = {{Adenosine/administration & dosage; Aged; Clopidogrel; Coronary Angiography; Coronary Circulation/drug effects; Drug Administration Schedule; Emergency Medical Services; Female; Humans; Male; Middle Aged; Myocardial Infarction/blood; Percutaneous Coronary Intervention/adverse effects; Platelet Aggregation Inhibitors/administration & dosage; Prasugrel Hydrochloride/administration & dosage; Purinergic P2Y Receptor Antagonists/administration & dosage; Ticagrelor; Ticlopidine/administration & dosage; Time Factors; Treatment Outcome}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{3}},
  pages        = {{31--623}},
  publisher    = {{Schattauer GmbH}},
  series       = {{Thrombosis and Haemostasis}},
  title        = {{Prehospital administration of P2Y12 inhibitors and early coronary reperfusion in primary PCI : an observational comparative study}},
  url          = {{http://dx.doi.org/10.1160/TH15-01-0026}},
  doi          = {{10.1160/TH15-01-0026}},
  volume       = {{114}},
  year         = {{2015}},
}