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Amyloid PET and cognitive decline in cognitively normal individuals : the SCIENCe project

Timmers, Tessa ; Ossenkoppele, Rik LU ; Verfaillie, Sander C.J. ; van der Weijden, Chris W.J. ; Slot, Rosalinde E.R. ; Wesselman, Linda M.P. ; Windhorst, Albert D. ; Wolters, Emma E. ; Yaqub, Maqsood and Prins, Niels D. , et al. (2019) In Neurobiology of Aging 79. p.50-58
Abstract


We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [
18
F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [
18
... (More)


We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [
18
F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [
18
F]florbetapir binding potential (BP
ND
), and we performed linear mixed models to assess the relationships between global [
18
F]florbetapir BP
ND
and neuropsychological performance. Higher [
18
F]florbetapir BP
ND
was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amyloid-β, Cognition, Positron emission tomography (PET), Preclinical Alzheimer's disease, Subjective cognitive decline (SCD)
in
Neurobiology of Aging
volume
79
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85064544165
  • pmid:31026622
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2019.02.020
language
English
LU publication?
yes
id
068ca9c0-8d3e-4e55-877a-d83a4b974dd1
date added to LUP
2019-05-02 15:03:33
date last changed
2024-04-16 03:09:48
@article{068ca9c0-8d3e-4e55-877a-d83a4b974dd1,
  abstract     = {{<p><br>
                                                         We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [                             <br>
                            <sup>18</sup><br>
                                                         F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [                             <br>
                            <sup>18</sup><br>
                                                         F]florbetapir binding potential (BP                             <br>
                            <sub>ND</sub><br>
                                                         ), and we performed linear mixed models to assess the relationships between global [                             <br>
                            <sup>18</sup><br>
                                                         F]florbetapir BP                             <br>
                            <sub>ND</sub><br>
                                                          and neuropsychological performance. Higher [                             <br>
                            <sup>18</sup><br>
                                                         F]florbetapir BP                             <br>
                            <sub>ND</sub><br>
                                                          was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p &lt; 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p &lt; 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p &lt; 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p &lt; 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p &lt; 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p &lt; 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.                         <br>
                        </p>}},
  author       = {{Timmers, Tessa and Ossenkoppele, Rik and Verfaillie, Sander C.J. and van der Weijden, Chris W.J. and Slot, Rosalinde E.R. and Wesselman, Linda M.P. and Windhorst, Albert D. and Wolters, Emma E. and Yaqub, Maqsood and Prins, Niels D. and Lammertsma, Adriaan A. and Scheltens, Philip and van der Flier, Wiesje M. and van Berckel, Bart N.M.}},
  issn         = {{0197-4580}},
  keywords     = {{Amyloid-β; Cognition; Positron emission tomography (PET); Preclinical Alzheimer's disease; Subjective cognitive decline (SCD)}},
  language     = {{eng}},
  pages        = {{50--58}},
  publisher    = {{Elsevier}},
  series       = {{Neurobiology of Aging}},
  title        = {{Amyloid PET and cognitive decline in cognitively normal individuals : the SCIENCe project}},
  url          = {{http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.020}},
  doi          = {{10.1016/j.neurobiolaging.2019.02.020}},
  volume       = {{79}},
  year         = {{2019}},
}