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Recent advances on CD4+ T cells in atherosclerosis and its implications for therapy

Grönberg, Caitríona LU ; Nilsson, Jan LU and Wigren, Maria LU (2017) In European Journal of Pharmacology 816. p.58-66
Abstract

Atherosclerosis is an arterial inflammatory disease and the primary cause of cardiovascular disease. T helper (Th) cells are an important part in atherosclerotic plaque as they can be either disease promoting or protective. A body of evidence points to a pro-atherosclerotic role of Th1 cells, whereas the role of Th2, Th17 and iNKT cells seems more complex and dependent on surrounding factors, including the developmental stage of the disease. Opposed to Th1 cells, there is convincing support for an anti-atherogenic role of Tregs. Recent data identify the plasticity of Th cells as an important challenge in understanding the functional role of different Th cell subsets in atherosclerosis. Much of the knowledge of Th cell function in... (More)

Atherosclerosis is an arterial inflammatory disease and the primary cause of cardiovascular disease. T helper (Th) cells are an important part in atherosclerotic plaque as they can be either disease promoting or protective. A body of evidence points to a pro-atherosclerotic role of Th1 cells, whereas the role of Th2, Th17 and iNKT cells seems more complex and dependent on surrounding factors, including the developmental stage of the disease. Opposed to Th1 cells, there is convincing support for an anti-atherogenic role of Tregs. Recent data identify the plasticity of Th cells as an important challenge in understanding the functional role of different Th cell subsets in atherosclerosis. Much of the knowledge of Th cell function in atherosclerosis is based on findings from experimental models and translating this into human disease is challenging. Targeting Th cells and/or their specific cytokines represents an attractive option for future therapy against atherosclerosis, although the benefits and the risk of modulation of Th cells with these novel drug targets must first be carefully assessed.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, CD4+ T helper cells, Cytokines, Inflammation, Therapy
in
European Journal of Pharmacology
volume
816
pages
58 - 66
publisher
Elsevier
external identifiers
  • scopus:85018347824
ISSN
0014-2999
DOI
10.1016/j.ejphar.2017.04.029
language
English
LU publication?
yes
id
0692b213-6f2f-4785-abc6-d4d8b3ae7bbb
date added to LUP
2017-05-24 14:15:19
date last changed
2018-01-07 12:05:16
@article{0692b213-6f2f-4785-abc6-d4d8b3ae7bbb,
  abstract     = {<p>Atherosclerosis is an arterial inflammatory disease and the primary cause of cardiovascular disease. T helper (Th) cells are an important part in atherosclerotic plaque as they can be either disease promoting or protective. A body of evidence points to a pro-atherosclerotic role of Th1 cells, whereas the role of Th2, Th17 and iNKT cells seems more complex and dependent on surrounding factors, including the developmental stage of the disease. Opposed to Th1 cells, there is convincing support for an anti-atherogenic role of Tregs. Recent data identify the plasticity of Th cells as an important challenge in understanding the functional role of different Th cell subsets in atherosclerosis. Much of the knowledge of Th cell function in atherosclerosis is based on findings from experimental models and translating this into human disease is challenging. Targeting Th cells and/or their specific cytokines represents an attractive option for future therapy against atherosclerosis, although the benefits and the risk of modulation of Th cells with these novel drug targets must first be carefully assessed.</p>},
  author       = {Grönberg, Caitríona and Nilsson, Jan and Wigren, Maria},
  issn         = {0014-2999},
  keyword      = {Atherosclerosis,CD4+ T helper cells,Cytokines,Inflammation,Therapy},
  language     = {eng},
  pages        = {58--66},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Recent advances on CD4<sup>+</sup> T cells in atherosclerosis and its implications for therapy},
  url          = {http://dx.doi.org/10.1016/j.ejphar.2017.04.029},
  volume       = {816},
  year         = {2017},
}