Recent advances on CD4+ T cells in atherosclerosis and its implications for therapy
(2017) In European Journal of Pharmacology 816. p.58-66- Abstract
Atherosclerosis is an arterial inflammatory disease and the primary cause of cardiovascular disease. T helper (Th) cells are an important part in atherosclerotic plaque as they can be either disease promoting or protective. A body of evidence points to a pro-atherosclerotic role of Th1 cells, whereas the role of Th2, Th17 and iNKT cells seems more complex and dependent on surrounding factors, including the developmental stage of the disease. Opposed to Th1 cells, there is convincing support for an anti-atherogenic role of Tregs. Recent data identify the plasticity of Th cells as an important challenge in understanding the functional role of different Th cell subsets in atherosclerosis. Much of the knowledge of Th cell function in... (More)
Atherosclerosis is an arterial inflammatory disease and the primary cause of cardiovascular disease. T helper (Th) cells are an important part in atherosclerotic plaque as they can be either disease promoting or protective. A body of evidence points to a pro-atherosclerotic role of Th1 cells, whereas the role of Th2, Th17 and iNKT cells seems more complex and dependent on surrounding factors, including the developmental stage of the disease. Opposed to Th1 cells, there is convincing support for an anti-atherogenic role of Tregs. Recent data identify the plasticity of Th cells as an important challenge in understanding the functional role of different Th cell subsets in atherosclerosis. Much of the knowledge of Th cell function in atherosclerosis is based on findings from experimental models and translating this into human disease is challenging. Targeting Th cells and/or their specific cytokines represents an attractive option for future therapy against atherosclerosis, although the benefits and the risk of modulation of Th cells with these novel drug targets must first be carefully assessed.
(Less)
- author
- Grönberg, Caitríona LU ; Nilsson, Jan LU and Wigren, Maria LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atherosclerosis, CD4+ T helper cells, Cytokines, Inflammation, Therapy
- in
- European Journal of Pharmacology
- volume
- 816
- pages
- 58 - 66
- publisher
- Elsevier
- external identifiers
-
- scopus:85018347824
- pmid:28457923
- ISSN
- 0014-2999
- DOI
- 10.1016/j.ejphar.2017.04.029
- language
- English
- LU publication?
- yes
- id
- 0692b213-6f2f-4785-abc6-d4d8b3ae7bbb
- date added to LUP
- 2017-05-24 14:15:19
- date last changed
- 2024-03-17 14:37:23
@article{0692b213-6f2f-4785-abc6-d4d8b3ae7bbb,
abstract = {{<p>Atherosclerosis is an arterial inflammatory disease and the primary cause of cardiovascular disease. T helper (Th) cells are an important part in atherosclerotic plaque as they can be either disease promoting or protective. A body of evidence points to a pro-atherosclerotic role of Th1 cells, whereas the role of Th2, Th17 and iNKT cells seems more complex and dependent on surrounding factors, including the developmental stage of the disease. Opposed to Th1 cells, there is convincing support for an anti-atherogenic role of Tregs. Recent data identify the plasticity of Th cells as an important challenge in understanding the functional role of different Th cell subsets in atherosclerosis. Much of the knowledge of Th cell function in atherosclerosis is based on findings from experimental models and translating this into human disease is challenging. Targeting Th cells and/or their specific cytokines represents an attractive option for future therapy against atherosclerosis, although the benefits and the risk of modulation of Th cells with these novel drug targets must first be carefully assessed.</p>}},
author = {{Grönberg, Caitríona and Nilsson, Jan and Wigren, Maria}},
issn = {{0014-2999}},
keywords = {{Atherosclerosis; CD4+ T helper cells; Cytokines; Inflammation; Therapy}},
language = {{eng}},
pages = {{58--66}},
publisher = {{Elsevier}},
series = {{European Journal of Pharmacology}},
title = {{Recent advances on CD4<sup>+</sup> T cells in atherosclerosis and its implications for therapy}},
url = {{http://dx.doi.org/10.1016/j.ejphar.2017.04.029}},
doi = {{10.1016/j.ejphar.2017.04.029}},
volume = {{816}},
year = {{2017}},
}