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Pathogenic T-cell responses in patients with autoimmune thrombocytopenic purpura

Semple, John W LU (2003) In Journal of Pediatric Hematology/Oncology 25 Suppl 1. p.3-11
Abstract

Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system, particularly in the spleen. This review surveys the recent current literature and updates our understanding of the cell-mediated immunology of AITP. It will focus on the relationship between T-cell reactivities and cytokine profiles in patients with AITP. Understanding these cellular immune aspects of AITP is vital for developing antigen-specific immunotherapies to treat the disease.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Cytokines/genetics, Humans, Purpura, Thrombocytopenic, Idiopathic/genetics, T-Lymphocytes/immunology
in
Journal of Pediatric Hematology/Oncology
volume
25 Suppl 1
pages
3 - 11
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0345166925
  • pmid:14668632
ISSN
1077-4114
DOI
10.1097/00043426-200312001-00003
language
English
LU publication?
no
id
06d2d67d-9d72-401d-8cca-ce1712e91aaa
date added to LUP
2022-11-09 15:25:41
date last changed
2025-01-11 13:41:07
@article{06d2d67d-9d72-401d-8cca-ce1712e91aaa,
  abstract     = {{<p>Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system, particularly in the spleen. This review surveys the recent current literature and updates our understanding of the cell-mediated immunology of AITP. It will focus on the relationship between T-cell reactivities and cytokine profiles in patients with AITP. Understanding these cellular immune aspects of AITP is vital for developing antigen-specific immunotherapies to treat the disease.</p>}},
  author       = {{Semple, John W}},
  issn         = {{1077-4114}},
  keywords     = {{Cytokines/genetics; Humans; Purpura, Thrombocytopenic, Idiopathic/genetics; T-Lymphocytes/immunology}},
  language     = {{eng}},
  pages        = {{3--11}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Pediatric Hematology/Oncology}},
  title        = {{Pathogenic T-cell responses in patients with autoimmune thrombocytopenic purpura}},
  url          = {{http://dx.doi.org/10.1097/00043426-200312001-00003}},
  doi          = {{10.1097/00043426-200312001-00003}},
  volume       = {{25 Suppl 1}},
  year         = {{2003}},
}