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Mapping the calcitonin receptor in human brain stem

Bower, Rebekah L.; Eftekhari, Sajedeh LU ; Waldvogel, Henry J.; Faull, Richard L M; Tajti, János; Edvinsson, Lars LU ; Hay, Debbie L. and Walker, Christopher S. (2016) In American Journal of Physiology - Regulatory Integrative and Comparative Physiology 310(9). p.788-793
Abstract

The calcitonin receptor (CTR) is relevant to three hormonal systems: amylin, calcitonin, and calcitonin gene-related peptide (CGRP). Receptors for amylin and calcitonin are targets for treating obesity, diabetes, and bone disorders. CGRP receptors represent a target for pain and migraine. Amylin receptors (AMY) are a heterodimer formed by the coexpression of CTR with receptor activity-modifying proteins (RAMPs). CTR with RAMP1 responds potently to both amylin and CGRP. The brain stem is a major site of action for circulating amylin and is a rich site of CGRP binding. This study aimed to enhance our understanding of these hormone systems by mapping CTR expression in the human brain stem, specifically the medulla oblongata. Widespread... (More)

The calcitonin receptor (CTR) is relevant to three hormonal systems: amylin, calcitonin, and calcitonin gene-related peptide (CGRP). Receptors for amylin and calcitonin are targets for treating obesity, diabetes, and bone disorders. CGRP receptors represent a target for pain and migraine. Amylin receptors (AMY) are a heterodimer formed by the coexpression of CTR with receptor activity-modifying proteins (RAMPs). CTR with RAMP1 responds potently to both amylin and CGRP. The brain stem is a major site of action for circulating amylin and is a rich site of CGRP binding. This study aimed to enhance our understanding of these hormone systems by mapping CTR expression in the human brain stem, specifically the medulla oblongata. Widespread CTR-like immunoreactivity was observed throughout the medulla. Dense CTR staining was noted in several discrete nuclei, including the nucleus of the solitary tract, the hypoglossal nucleus, the cuneate nucleus, spinal trigeminal nucleus, the gracile nucleus, and the inferior olivary nucleus. CTR staining was also observed in the area postrema, the lateral reticular nucleus, and the pyramidal tract. The extensive expression of CTR in the medulla suggests that CTR may be involved in a wider range of functions than currently appreciated.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amylin, Brain stem, Calcitonin gene-related peptide, Migraine, Obesity
in
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
volume
310
issue
9
pages
788 - 793
publisher
American Physiological Society
external identifiers
  • Scopus:84984618911
  • WOS:000376465900002
ISSN
0363-6119
DOI
10.1152/ajpregu.00539.2015
language
English
LU publication?
yes
id
06e909fb-92e7-430e-8ee0-7c65477569b1
date added to LUP
2016-10-04 09:31:05
date last changed
2017-01-29 04:32:48
@article{06e909fb-92e7-430e-8ee0-7c65477569b1,
  abstract     = {<p>The calcitonin receptor (CTR) is relevant to three hormonal systems: amylin, calcitonin, and calcitonin gene-related peptide (CGRP). Receptors for amylin and calcitonin are targets for treating obesity, diabetes, and bone disorders. CGRP receptors represent a target for pain and migraine. Amylin receptors (AMY) are a heterodimer formed by the coexpression of CTR with receptor activity-modifying proteins (RAMPs). CTR with RAMP1 responds potently to both amylin and CGRP. The brain stem is a major site of action for circulating amylin and is a rich site of CGRP binding. This study aimed to enhance our understanding of these hormone systems by mapping CTR expression in the human brain stem, specifically the medulla oblongata. Widespread CTR-like immunoreactivity was observed throughout the medulla. Dense CTR staining was noted in several discrete nuclei, including the nucleus of the solitary tract, the hypoglossal nucleus, the cuneate nucleus, spinal trigeminal nucleus, the gracile nucleus, and the inferior olivary nucleus. CTR staining was also observed in the area postrema, the lateral reticular nucleus, and the pyramidal tract. The extensive expression of CTR in the medulla suggests that CTR may be involved in a wider range of functions than currently appreciated.</p>},
  author       = {Bower, Rebekah L. and Eftekhari, Sajedeh and Waldvogel, Henry J. and Faull, Richard L M and Tajti, János and Edvinsson, Lars and Hay, Debbie L. and Walker, Christopher S.},
  issn         = {0363-6119},
  keyword      = {Amylin,Brain stem,Calcitonin gene-related peptide,Migraine,Obesity},
  language     = {eng},
  month        = {05},
  number       = {9},
  pages        = {788--793},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology - Regulatory Integrative and Comparative Physiology},
  title        = {Mapping the calcitonin receptor in human brain stem},
  url          = {http://dx.doi.org/10.1152/ajpregu.00539.2015},
  volume       = {310},
  year         = {2016},
}