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Plasma Adrenaline Increases in Anesthetized Patients Given Electro-acupuncture Before Surgery

Kvorning, Nina and Åkeson, Jonas LU (2010) In Pain Medicine 11(7). p.1126-1131
Abstract
Purpose. In anesthetized patients, electro-acupuncture (EA) has been found to reduce sevoflurane-induced suppression of cranial and spinal motor responses to surgery without influencing the level of anesthesia. The underlying mechanisms are unclear. In the present study, blood samples were analyzed to evaluate if the increased clinical motor responses to surgery in patients subjected to EA under sevoflurane anesthesia are also reflected in higher plasma levels of catecholamines, adrenocorticotrophic hormone (ACTH), or cortisol. Methods. Blood samples were obtained before anesthetic induction, soon after the study or control procedures had been completed under general anesthesia, and after 30 minutes of surgery under steady-state anesthesia... (More)
Purpose. In anesthetized patients, electro-acupuncture (EA) has been found to reduce sevoflurane-induced suppression of cranial and spinal motor responses to surgery without influencing the level of anesthesia. The underlying mechanisms are unclear. In the present study, blood samples were analyzed to evaluate if the increased clinical motor responses to surgery in patients subjected to EA under sevoflurane anesthesia are also reflected in higher plasma levels of catecholamines, adrenocorticotrophic hormone (ACTH), or cortisol. Methods. Blood samples were obtained before anesthetic induction, soon after the study or control procedures had been completed under general anesthesia, and after 30 minutes of surgery under steady-state anesthesia with 1.8% of sevoflurane, in 45 healthy female patients, scheduled for sterilization by laparoscopy, randomized for bilateral 2 Hz-burst EA (study group; n = 22) or control (control group; n = 23) procedures. Result. Plasma levels of adrenaline were found to approach the higher preanesthetic level after 30 minutes of surgery in patients given EA stimulation but to remain low in control patients (P < 0.05)-in agreement with the stronger clinical motor responses to skin incision in the EA group. Plasma levels of noradrenaline, ACTH, and cortisol did not change in or differ between the two groups. Conclusion. The clinical facilitation of both cranial and spinal motor responses to surgery in patients given acupuncture under sevoflurane anesthesia is associated with increased plasma levels of adrenaline, possibly reflecting sympathetic activation. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Noradrenaline, Cortisol, Catecholamine, Inhalational, Anesthesia, Adrenocorticotrophic Hormone, Acupuncture, Adrenaline, Surgery, Sevoflurane, Pain
in
Pain Medicine
volume
11
issue
7
pages
1126 - 1131
publisher
Wiley-Blackwell
external identifiers
  • wos:000279125000018
  • scopus:77955167836
ISSN
1526-2375
DOI
10.1111/j.1526-4637.2010.00878.x
language
English
LU publication?
yes
id
07072004-b5df-425f-b0cc-f2ce5d87a716 (old id 1629953)
date added to LUP
2010-07-22 09:39:37
date last changed
2018-11-21 19:48:05
@article{07072004-b5df-425f-b0cc-f2ce5d87a716,
  abstract     = {Purpose. In anesthetized patients, electro-acupuncture (EA) has been found to reduce sevoflurane-induced suppression of cranial and spinal motor responses to surgery without influencing the level of anesthesia. The underlying mechanisms are unclear. In the present study, blood samples were analyzed to evaluate if the increased clinical motor responses to surgery in patients subjected to EA under sevoflurane anesthesia are also reflected in higher plasma levels of catecholamines, adrenocorticotrophic hormone (ACTH), or cortisol. Methods. Blood samples were obtained before anesthetic induction, soon after the study or control procedures had been completed under general anesthesia, and after 30 minutes of surgery under steady-state anesthesia with 1.8% of sevoflurane, in 45 healthy female patients, scheduled for sterilization by laparoscopy, randomized for bilateral 2 Hz-burst EA (study group; n = 22) or control (control group; n = 23) procedures. Result. Plasma levels of adrenaline were found to approach the higher preanesthetic level after 30 minutes of surgery in patients given EA stimulation but to remain low in control patients (P &lt; 0.05)-in agreement with the stronger clinical motor responses to skin incision in the EA group. Plasma levels of noradrenaline, ACTH, and cortisol did not change in or differ between the two groups. Conclusion. The clinical facilitation of both cranial and spinal motor responses to surgery in patients given acupuncture under sevoflurane anesthesia is associated with increased plasma levels of adrenaline, possibly reflecting sympathetic activation.},
  author       = {Kvorning, Nina and Åkeson, Jonas},
  issn         = {1526-2375},
  keyword      = {Noradrenaline,Cortisol,Catecholamine,Inhalational,Anesthesia,Adrenocorticotrophic Hormone,Acupuncture,Adrenaline,Surgery,Sevoflurane,Pain},
  language     = {eng},
  number       = {7},
  pages        = {1126--1131},
  publisher    = {Wiley-Blackwell},
  series       = {Pain Medicine},
  title        = {Plasma Adrenaline Increases in Anesthetized Patients Given Electro-acupuncture Before Surgery},
  url          = {http://dx.doi.org/10.1111/j.1526-4637.2010.00878.x},
  volume       = {11},
  year         = {2010},
}