Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Neurocognitive function following out-of-hospital cardiac arrest : A systematic review

Zook, Nancy ; Voss, Sarah ; Blennow Nordström, Erik LU orcid ; Brett, Stephen J. ; Jenkinson, Elizabeth ; Shaw, Pauline ; White, Paul and Benger, Jonathan (2022) In Resuscitation 170. p.238-246
Abstract

Objectives: The primary aim of this review was to investigate neurocognitive outcomes following out-of-hospital cardiac arrest (OHCA). Specifically, the focus was on identifying the different neurocognitive domains that are assessed, the measures used, and the level of, and criteria for, impairment. Design and review methods: A systematic review of the literature from 2006 to 2021 was completed using Medline, Cinahl and Psychinfo. Criteria for inclusion were studies with participants over the age of 18, OHCA and at least one neurocognitive function measure. Qualitative and case studies were excluded. Reviewers assessed criteria and risk of bias using a modified version of Downs and Black. Results: Forty-three studies were identified.... (More)

Objectives: The primary aim of this review was to investigate neurocognitive outcomes following out-of-hospital cardiac arrest (OHCA). Specifically, the focus was on identifying the different neurocognitive domains that are assessed, the measures used, and the level of, and criteria for, impairment. Design and review methods: A systematic review of the literature from 2006 to 2021 was completed using Medline, Cinahl and Psychinfo. Criteria for inclusion were studies with participants over the age of 18, OHCA and at least one neurocognitive function measure. Qualitative and case studies were excluded. Reviewers assessed criteria and risk of bias using a modified version of Downs and Black. Results: Forty-three studies were identified. Most studies had a low risk of bias (n = 31) or moderate risk of bias (n = 11) and one had a high risk; however, only six reported effect sizes or power analyses. Multiple measures of neurocognitive outcomes were used (>50) and level of impairment criteria varied considerably. Memory impairments were frequently found and were also more likely to be impaired followed by executive function and processing speed. Discussion: This review highlights the heterogeneity of measures and approaches used to assess neurocognitive outcomes following OHCA as well as the need to improve risk of bias concerning generalizability. Improved understanding of the approaches used for assessment and the subsequent findings will facilitate a standardized evaluation of neurocognitive outcomes following OHCA.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Executive functions, Memory, Neurocognitive outcomes, Out-of-hospital cardiac arrest
in
Resuscitation
volume
170
pages
238 - 246
publisher
Elsevier
external identifiers
  • pmid:34648921
  • scopus:85118354033
ISSN
0300-9572
DOI
10.1016/j.resuscitation.2021.10.005
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021
id
070b8b1e-0d84-4433-b03d-4b6a77e08f8c
date added to LUP
2021-11-22 11:38:09
date last changed
2024-06-15 20:53:09
@article{070b8b1e-0d84-4433-b03d-4b6a77e08f8c,
  abstract     = {{<p>Objectives: The primary aim of this review was to investigate neurocognitive outcomes following out-of-hospital cardiac arrest (OHCA). Specifically, the focus was on identifying the different neurocognitive domains that are assessed, the measures used, and the level of, and criteria for, impairment. Design and review methods: A systematic review of the literature from 2006 to 2021 was completed using Medline, Cinahl and Psychinfo. Criteria for inclusion were studies with participants over the age of 18, OHCA and at least one neurocognitive function measure. Qualitative and case studies were excluded. Reviewers assessed criteria and risk of bias using a modified version of Downs and Black. Results: Forty-three studies were identified. Most studies had a low risk of bias (n = 31) or moderate risk of bias (n = 11) and one had a high risk; however, only six reported effect sizes or power analyses. Multiple measures of neurocognitive outcomes were used (&gt;50) and level of impairment criteria varied considerably. Memory impairments were frequently found and were also more likely to be impaired followed by executive function and processing speed. Discussion: This review highlights the heterogeneity of measures and approaches used to assess neurocognitive outcomes following OHCA as well as the need to improve risk of bias concerning generalizability. Improved understanding of the approaches used for assessment and the subsequent findings will facilitate a standardized evaluation of neurocognitive outcomes following OHCA.</p>}},
  author       = {{Zook, Nancy and Voss, Sarah and Blennow Nordström, Erik and Brett, Stephen J. and Jenkinson, Elizabeth and Shaw, Pauline and White, Paul and Benger, Jonathan}},
  issn         = {{0300-9572}},
  keywords     = {{Executive functions; Memory; Neurocognitive outcomes; Out-of-hospital cardiac arrest}},
  language     = {{eng}},
  pages        = {{238--246}},
  publisher    = {{Elsevier}},
  series       = {{Resuscitation}},
  title        = {{Neurocognitive function following out-of-hospital cardiac arrest : A systematic review}},
  url          = {{http://dx.doi.org/10.1016/j.resuscitation.2021.10.005}},
  doi          = {{10.1016/j.resuscitation.2021.10.005}},
  volume       = {{170}},
  year         = {{2022}},
}