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Cardiac arrest in COVID-19 : characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation

Sultanian, Pedram ; Lundgren, Peter ; Strömsöe, Anneli ; Aune, Solveig ; Bergström, Göran ; Hagberg, Eva ; Hollenberg, Jacob ; Lindqvist, Jonny ; Djärv, Therese and Castelheim, Albert , et al. (2021) In European Heart Journal 42(11). p.1094-1106
Abstract

AIM: To study the characteristics and outcome among cardiac arrest cases with COVID-19 and differences between the pre-pandemic and the pandemic period in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA). METHOD AND RESULTS: We included all patients reported to the Swedish Registry for Cardiopulmonary Resuscitation from 1 January to 20 July 2020. We defined 16 March 2020 as the start of the pandemic. We assessed overall and 30-day mortality using Cox regression and logistic regression, respectively. We studied 1946 cases of OHCA and 1080 cases of IHCA during the entire period. During the pandemic, 88 (10.0%) of OHCAs and 72 (16.1%) of IHCAs had ongoing COVID-19. With regards to OHCA during the pandemic, the... (More)

AIM: To study the characteristics and outcome among cardiac arrest cases with COVID-19 and differences between the pre-pandemic and the pandemic period in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA). METHOD AND RESULTS: We included all patients reported to the Swedish Registry for Cardiopulmonary Resuscitation from 1 January to 20 July 2020. We defined 16 March 2020 as the start of the pandemic. We assessed overall and 30-day mortality using Cox regression and logistic regression, respectively. We studied 1946 cases of OHCA and 1080 cases of IHCA during the entire period. During the pandemic, 88 (10.0%) of OHCAs and 72 (16.1%) of IHCAs had ongoing COVID-19. With regards to OHCA during the pandemic, the odds ratio for 30-day mortality in COVID-19-positive cases, compared with COVID-19-negative cases, was 3.40 [95% confidence interval (CI) 1.31-11.64]; the corresponding hazard ratio was 1.45 (95% CI 1.13-1.85). Adjusted 30-day survival was 4.7% for patients with COVID-19, 9.8% for patients without COVID-19, and 7.6% in the pre-pandemic period. With regards to IHCA during the pandemic, the odds ratio for COVID-19-positive cases, compared with COVID-19-negative cases, was 2.27 (95% CI 1.27-4.24); the corresponding hazard ratio was 1.48 (95% CI 1.09-2.01). Adjusted 30-day survival was 23.1% in COVID-19-positive cases, 39.5% in patients without COVID-19, and 36.4% in the pre-pandemic period. CONCLUSION: During the pandemic phase, COVID-19 was involved in at least 10% of all OHCAs and 16% of IHCAs, and, among COVID-19 cases, 30-day mortality was increased 3.4-fold in OHCA and 2.3-fold in IHCA.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiac arrest, COVID-19
in
European Heart Journal
volume
42
issue
11
pages
13 pages
publisher
Oxford University Press
external identifiers
  • scopus:85102963965
  • pmid:33543259
ISSN
1522-9645
DOI
10.1093/eurheartj/ehaa1067
language
English
LU publication?
yes
id
071d4c1f-0067-43cb-875e-97661e340f62
date added to LUP
2021-03-31 08:46:18
date last changed
2024-03-08 10:16:32
@article{071d4c1f-0067-43cb-875e-97661e340f62,
  abstract     = {{<p>AIM: To study the characteristics and outcome among cardiac arrest cases with COVID-19 and differences between the pre-pandemic and the pandemic period in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA). METHOD AND RESULTS: We included all patients reported to the Swedish Registry for Cardiopulmonary Resuscitation from 1 January to 20 July 2020. We defined 16 March 2020 as the start of the pandemic. We assessed overall and 30-day mortality using Cox regression and logistic regression, respectively. We studied 1946 cases of OHCA and 1080 cases of IHCA during the entire period. During the pandemic, 88 (10.0%) of OHCAs and 72 (16.1%) of IHCAs had ongoing COVID-19. With regards to OHCA during the pandemic, the odds ratio for 30-day mortality in COVID-19-positive cases, compared with COVID-19-negative cases, was 3.40 [95% confidence interval (CI) 1.31-11.64]; the corresponding hazard ratio was 1.45 (95% CI 1.13-1.85). Adjusted 30-day survival was 4.7% for patients with COVID-19, 9.8% for patients without COVID-19, and 7.6% in the pre-pandemic period. With regards to IHCA during the pandemic, the odds ratio for COVID-19-positive cases, compared with COVID-19-negative cases, was 2.27 (95% CI 1.27-4.24); the corresponding hazard ratio was 1.48 (95% CI 1.09-2.01). Adjusted 30-day survival was 23.1% in COVID-19-positive cases, 39.5% in patients without COVID-19, and 36.4% in the pre-pandemic period. CONCLUSION: During the pandemic phase, COVID-19 was involved in at least 10% of all OHCAs and 16% of IHCAs, and, among COVID-19 cases, 30-day mortality was increased 3.4-fold in OHCA and 2.3-fold in IHCA.</p>}},
  author       = {{Sultanian, Pedram and Lundgren, Peter and Strömsöe, Anneli and Aune, Solveig and Bergström, Göran and Hagberg, Eva and Hollenberg, Jacob and Lindqvist, Jonny and Djärv, Therese and Castelheim, Albert and Thorén, Anna and Hessulf, Fredrik and Svensson, Leif and Claesson, Andreas and Friberg, Hans and Nordberg, Per and Omerovic, Elmir and Rosengren, Annika and Herlitz, Johan and Rawshani, Araz}},
  issn         = {{1522-9645}},
  keywords     = {{Cardiac arrest; COVID-19}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1094--1106}},
  publisher    = {{Oxford University Press}},
  series       = {{European Heart Journal}},
  title        = {{Cardiac arrest in COVID-19 : characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation}},
  url          = {{http://dx.doi.org/10.1093/eurheartj/ehaa1067}},
  doi          = {{10.1093/eurheartj/ehaa1067}},
  volume       = {{42}},
  year         = {{2021}},
}