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Vitamin K and cancer

Dahlberg, Sofia; Ede, Jacob and Schött, Ulf LU (2017) In Scandinavian Journal of Clinical and Laboratory Investigation
Abstract

Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent... (More)

Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
anticoagulants, apoptosis, cell cycle checkpoints, growth arrest-specific protein 6, matrix Gla protein, neoplasm, osteocalcin, PIVKA-II, steroid and xenobiotic receptor, Vitamin K
in
Scandinavian Journal of Clinical and Laboratory Investigation
pages
13 pages
publisher
Informa Healthcare
external identifiers
  • scopus:85029671703
ISSN
0036-5513
DOI
10.1080/00365513.2017.1379090
language
English
LU publication?
yes
id
071ed190-3f65-4c56-bdad-586ddba50c2f
date added to LUP
2017-10-05 13:40:09
date last changed
2018-01-07 12:20:50
@article{071ed190-3f65-4c56-bdad-586ddba50c2f,
  abstract     = {<p>Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.</p>},
  author       = {Dahlberg, Sofia and Ede, Jacob and Schött, Ulf},
  issn         = {0036-5513},
  keyword      = {anticoagulants,apoptosis,cell cycle checkpoints,growth arrest-specific protein 6,matrix Gla protein,neoplasm,osteocalcin,PIVKA-II,steroid and xenobiotic receptor,Vitamin K},
  language     = {eng},
  month        = {09},
  pages        = {13},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical and Laboratory Investigation},
  title        = {Vitamin K and cancer},
  url          = {http://dx.doi.org/10.1080/00365513.2017.1379090},
  year         = {2017},
}