Vitamin K and cancer
(2017) In Scandinavian Journal of Clinical and Laboratory Investigation 77(8). p.555-567- Abstract
Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent... (More)
Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.
(Less)
- author
- Dahlberg, Sofia
LU
; Ede, Jacob
LU
and Schött, Ulf LU
- organization
- publishing date
- 2017-09-21
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anticoagulants, apoptosis, cell cycle checkpoints, growth arrest-specific protein 6, matrix Gla protein, neoplasm, osteocalcin, PIVKA-II, steroid and xenobiotic receptor, Vitamin K
- in
- Scandinavian Journal of Clinical and Laboratory Investigation
- volume
- 77
- issue
- 8
- pages
- 555 - 567
- publisher
- Informa Healthcare
- external identifiers
-
- scopus:85029671703
- pmid:28933567
- ISSN
- 0036-5513
- DOI
- 10.1080/00365513.2017.1379090
- project
- Koagulation vid kirurgi och kritisk sjukdom
- language
- English
- LU publication?
- yes
- id
- 071ed190-3f65-4c56-bdad-586ddba50c2f
- date added to LUP
- 2017-10-05 13:40:09
- date last changed
- 2025-01-07 22:01:41
@article{071ed190-3f65-4c56-bdad-586ddba50c2f, abstract = {{<p>Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.</p>}}, author = {{Dahlberg, Sofia and Ede, Jacob and Schött, Ulf}}, issn = {{0036-5513}}, keywords = {{anticoagulants; apoptosis; cell cycle checkpoints; growth arrest-specific protein 6; matrix Gla protein; neoplasm; osteocalcin; PIVKA-II; steroid and xenobiotic receptor; Vitamin K}}, language = {{eng}}, month = {{09}}, number = {{8}}, pages = {{555--567}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Clinical and Laboratory Investigation}}, title = {{Vitamin K and cancer}}, url = {{http://dx.doi.org/10.1080/00365513.2017.1379090}}, doi = {{10.1080/00365513.2017.1379090}}, volume = {{77}}, year = {{2017}}, }