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Vitamin K and cancer

Dahlberg, Sofia LU ; Ede, Jacob LU orcid and Schött, Ulf LU (2017) In Scandinavian Journal of Clinical and Laboratory Investigation 77(8). p.555-567
Abstract

Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent... (More)

Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anticoagulants, apoptosis, cell cycle checkpoints, growth arrest-specific protein 6, matrix Gla protein, neoplasm, osteocalcin, PIVKA-II, steroid and xenobiotic receptor, Vitamin K
in
Scandinavian Journal of Clinical and Laboratory Investigation
volume
77
issue
8
pages
555 - 567
publisher
Informa Healthcare
external identifiers
  • scopus:85029671703
  • pmid:28933567
ISSN
0036-5513
DOI
10.1080/00365513.2017.1379090
project
Koagulation vid kirurgi och kritisk sjukdom
language
English
LU publication?
yes
id
071ed190-3f65-4c56-bdad-586ddba50c2f
date added to LUP
2017-10-05 13:40:09
date last changed
2024-02-13 08:13:43
@article{071ed190-3f65-4c56-bdad-586ddba50c2f,
  abstract     = {{<p>Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.</p>}},
  author       = {{Dahlberg, Sofia and Ede, Jacob and Schött, Ulf}},
  issn         = {{0036-5513}},
  keywords     = {{anticoagulants; apoptosis; cell cycle checkpoints; growth arrest-specific protein 6; matrix Gla protein; neoplasm; osteocalcin; PIVKA-II; steroid and xenobiotic receptor; Vitamin K}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{8}},
  pages        = {{555--567}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical and Laboratory Investigation}},
  title        = {{Vitamin K and cancer}},
  url          = {{http://dx.doi.org/10.1080/00365513.2017.1379090}},
  doi          = {{10.1080/00365513.2017.1379090}},
  volume       = {{77}},
  year         = {{2017}},
}