Risk of atherosclerotic cardiovascular disease after cancer diagnosis : findings from three prospective cohort studies
Liu, Qiang ; Wang, Qiaoli LU
; Wang, Kai
; Han, Han
; Wang, Molin
; Wang, Jing
; Song, Mingyang
and Giovannucci, Edward
(2025)
In Journal of the National Cancer Institute
- Abstract
BACKGROUND: To determine the association between cancer diagnosis and subsequent risk of ASCVD, and to examine the trajectory of the association over time after cancer diagnosis.
METHODS: We prospectively followed 108,689 women in the Nurses' Health Study (NHS) (1984-2020), 113,569 women in the NHSII (1991-2019), and 45,328 men in the Health Professionals Follow-up Study (HPFS) (1986-2016) who were free of ASCVD and cancer at baseline. We conducted multivariable-adjusted time-varying Cox proportional hazards regression models to assess ASCVD risk following individual cancer diagnosis.
RESULTS: During up to 36 years of follow-up, 4,334 new-onset ASCVD events among 49,603 incident cancer cases were documented. After adjusting... (More)
BACKGROUND: To determine the association between cancer diagnosis and subsequent risk of ASCVD, and to examine the trajectory of the association over time after cancer diagnosis.
METHODS: We prospectively followed 108,689 women in the Nurses' Health Study (NHS) (1984-2020), 113,569 women in the NHSII (1991-2019), and 45,328 men in the Health Professionals Follow-up Study (HPFS) (1986-2016) who were free of ASCVD and cancer at baseline. We conducted multivariable-adjusted time-varying Cox proportional hazards regression models to assess ASCVD risk following individual cancer diagnosis.
RESULTS: During up to 36 years of follow-up, 4,334 new-onset ASCVD events among 49,603 incident cancer cases were documented. After adjusting for shared risk factors, cervical cancer (HR: 1.56; 95%CI: 1.06-2.29) and Hodgkin lymphoma (HR: 2.80; 95%CI: 1.89-4.15) was associated with increased risk of ASCVD incidence, while prostate cancer was associated with a lower ASCVD incidence (HR: 0.91; 95% CI: 0.85-0.97). Compared to cancer-free individuals, breast cancer survivors experienced lower ASCVD risk during the first 7.5 years but gradually increased afterwards (Pnon-linearity=0.01). The risk of ASCVD increased over time among patients with cancers of the colorectum (P = .003), lung (P = .002), and endometrium (P = .04). No significant association with ASCVD risk was observed for cancers of the oral cavity and pharynx, sarcoma, melanoma, kidney, thyroid, leukemia, or ovary.
CONCLUSIONS: Cervical cancer or Hodgkin lymphoma was associated with an increased risk of new-onset ASCVD, independent of shared risk factors, while no increased risk was found with other cancers. ASCVD risk trajectories varied over time after diagnosis according to cancer types.
(Less)
- author
- Liu, Qiang
; Wang, Qiaoli
LU
; Wang, Kai
; Han, Han
; Wang, Molin
; Wang, Jing
; Song, Mingyang
and Giovannucci, Edward
- publishing date
- 2025-05-30
- type
- Contribution to journal
- publication status
- epub
- in
- Journal of the National Cancer Institute
- publisher
- Oxford University Press
- external identifiers
-
- pmid:40445187
- ISSN
- 1460-2105
- DOI
- 10.1093/jnci/djaf122
- language
- English
- LU publication?
- no
- additional info
- © The Author(s) 2025. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
- id
- 075d9134-9e83-437f-a33a-7a51118cc209
- date added to LUP
- 2025-06-26 18:09:23
- date last changed
- 2025-06-27 08:14:34
@article{075d9134-9e83-437f-a33a-7a51118cc209,
abstract = {{<p>BACKGROUND: To determine the association between cancer diagnosis and subsequent risk of ASCVD, and to examine the trajectory of the association over time after cancer diagnosis.</p><p>METHODS: We prospectively followed 108,689 women in the Nurses' Health Study (NHS) (1984-2020), 113,569 women in the NHSII (1991-2019), and 45,328 men in the Health Professionals Follow-up Study (HPFS) (1986-2016) who were free of ASCVD and cancer at baseline. We conducted multivariable-adjusted time-varying Cox proportional hazards regression models to assess ASCVD risk following individual cancer diagnosis.</p><p>RESULTS: During up to 36 years of follow-up, 4,334 new-onset ASCVD events among 49,603 incident cancer cases were documented. After adjusting for shared risk factors, cervical cancer (HR: 1.56; 95%CI: 1.06-2.29) and Hodgkin lymphoma (HR: 2.80; 95%CI: 1.89-4.15) was associated with increased risk of ASCVD incidence, while prostate cancer was associated with a lower ASCVD incidence (HR: 0.91; 95% CI: 0.85-0.97). Compared to cancer-free individuals, breast cancer survivors experienced lower ASCVD risk during the first 7.5 years but gradually increased afterwards (Pnon-linearity=0.01). The risk of ASCVD increased over time among patients with cancers of the colorectum (P = .003), lung (P = .002), and endometrium (P = .04). No significant association with ASCVD risk was observed for cancers of the oral cavity and pharynx, sarcoma, melanoma, kidney, thyroid, leukemia, or ovary.</p><p>CONCLUSIONS: Cervical cancer or Hodgkin lymphoma was associated with an increased risk of new-onset ASCVD, independent of shared risk factors, while no increased risk was found with other cancers. ASCVD risk trajectories varied over time after diagnosis according to cancer types.</p>}},
author = {{Liu, Qiang and Wang, Qiaoli and Wang, Kai and Han, Han and Wang, Molin and Wang, Jing and Song, Mingyang and Giovannucci, Edward}},
issn = {{1460-2105}},
language = {{eng}},
month = {{05}},
publisher = {{Oxford University Press}},
series = {{Journal of the National Cancer Institute}},
title = {{Risk of atherosclerotic cardiovascular disease after cancer diagnosis : findings from three prospective cohort studies}},
url = {{http://dx.doi.org/10.1093/jnci/djaf122}},
doi = {{10.1093/jnci/djaf122}},
year = {{2025}},
}