Mathematical modeling of the protein corona : Implications for nanoparticulate delivery systems
(2016) 2. p.53-65- Abstract
This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, but most intriguing are the observed differences in delivery effi ciency in vivo compared with protein-free in vitro conditions. In order to understand possible situations that the nanoparticle will face in a protein-rich biological environment, we will fi rst describe the formation of a protein corona and thereafter discuss potential... (More)
This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, but most intriguing are the observed differences in delivery effi ciency in vivo compared with protein-free in vitro conditions. In order to understand possible situations that the nanoparticle will face in a protein-rich biological environment, we will fi rst describe the formation of a protein corona and thereafter discuss potential perturbations of the delivery systems when moving from in vitro testing to in vivo applications. We emphasize the role of mathematical modeling in optimizing the design of functionalized nanoparticles to achieve high success of delivery.
(Less)
- author
- Dell'Orco, Daniele LU ; Lundqvist, Martin LU ; Linse, Sara LU and Cedervall, Tommy LU
- organization
- publishing date
- 2016-04-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Delivery, Mathematical modeling, Nanoparticle, Protein corona, Targeting
- host publication
- Handbook of Immunological Properties of Engineered Nanomaterials: : Haematocompatibility of Engineered Nanomaterials - Haematocompatibility of Engineered Nanomaterials
- volume
- 2
- edition
- 2
- pages
- 13 pages
- publisher
- World Scientific Publishing
- external identifiers
-
- scopus:85019836058
- ISBN
- 9789814699167
- 9789814699174
- DOI
- 10.1142/9677
- language
- English
- LU publication?
- yes
- id
- 077e5c86-f674-47c3-9869-de953fc9dfc6
- date added to LUP
- 2017-06-27 12:06:14
- date last changed
- 2025-01-07 16:02:32
@inbook{077e5c86-f674-47c3-9869-de953fc9dfc6, abstract = {{<p>This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, but most intriguing are the observed differences in delivery effi ciency in vivo compared with protein-free in vitro conditions. In order to understand possible situations that the nanoparticle will face in a protein-rich biological environment, we will fi rst describe the formation of a protein corona and thereafter discuss potential perturbations of the delivery systems when moving from in vitro testing to in vivo applications. We emphasize the role of mathematical modeling in optimizing the design of functionalized nanoparticles to achieve high success of delivery.</p>}}, author = {{Dell'Orco, Daniele and Lundqvist, Martin and Linse, Sara and Cedervall, Tommy}}, booktitle = {{Handbook of Immunological Properties of Engineered Nanomaterials: : Haematocompatibility of Engineered Nanomaterials}}, isbn = {{9789814699167}}, keywords = {{Delivery; Mathematical modeling; Nanoparticle; Protein corona; Targeting}}, language = {{eng}}, month = {{04}}, pages = {{53--65}}, publisher = {{World Scientific Publishing}}, title = {{Mathematical modeling of the protein corona : Implications for nanoparticulate delivery systems}}, url = {{http://dx.doi.org/10.1142/9677}}, doi = {{10.1142/9677}}, volume = {{2}}, year = {{2016}}, }