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Mathematical modeling of the protein corona : Implications for nanoparticulate delivery systems

Dell'Orco, Daniele LU ; Lundqvist, Martin LU ; Linse, Sara LU and Cedervall, Tommy LU (2016) In Handbook of Immunological Properties of Engineered Nanomaterials: 2. p.53-65
Abstract

This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, but most intriguing are the observed differences in delivery effi ciency in vivo compared with protein-free in vitro conditions. In order to understand possible situations that the nanoparticle will face in a protein-rich biological environment, we will fi rst describe the formation of a protein corona and thereafter discuss potential... (More)

This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, but most intriguing are the observed differences in delivery effi ciency in vivo compared with protein-free in vitro conditions. In order to understand possible situations that the nanoparticle will face in a protein-rich biological environment, we will fi rst describe the formation of a protein corona and thereafter discuss potential perturbations of the delivery systems when moving from in vitro testing to in vivo applications. We emphasize the role of mathematical modeling in optimizing the design of functionalized nanoparticles to achieve high success of delivery.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Delivery, Mathematical modeling, Nanoparticle, Protein corona, Targeting
in
Handbook of Immunological Properties of Engineered Nanomaterials:
volume
2
pages
13 pages
publisher
World Scientific Publishing Co. Pte. Ltd., Hackensack, NJ
external identifiers
  • scopus:85019836058
ISBN
9789814699167
9789814699174
DOI
10.1142/9677
language
English
LU publication?
yes
id
077e5c86-f674-47c3-9869-de953fc9dfc6
date added to LUP
2017-06-27 12:06:14
date last changed
2017-08-23 13:24:01
@inbook{077e5c86-f674-47c3-9869-de953fc9dfc6,
  abstract     = {<p>This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, but most intriguing are the observed differences in delivery effi ciency in vivo compared with protein-free in vitro conditions. In order to understand possible situations that the nanoparticle will face in a protein-rich biological environment, we will fi rst describe the formation of a protein corona and thereafter discuss potential perturbations of the delivery systems when moving from in vitro testing to in vivo applications. We emphasize the role of mathematical modeling in optimizing the design of functionalized nanoparticles to achieve high success of delivery.</p>},
  author       = {Dell'Orco, Daniele and Lundqvist, Martin and Linse, Sara and Cedervall, Tommy},
  isbn         = {9789814699167},
  keyword      = {Delivery,Mathematical modeling,Nanoparticle,Protein corona,Targeting},
  language     = {eng},
  month        = {04},
  pages        = {53--65},
  publisher    = {World Scientific Publishing Co. Pte. Ltd., Hackensack, NJ},
  series       = {Handbook of Immunological Properties of Engineered Nanomaterials: },
  title        = {Mathematical modeling of the protein corona : Implications for nanoparticulate delivery systems},
  url          = {http://dx.doi.org/10.1142/9677},
  volume       = {2},
  year         = {2016},
}