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Roles and regulation of tRNA-derived small RNAs in animals

Muthukumar, Sowndarya LU ; Li, Cai Tao ; Liu, Ru Juan and Bellodi, Cristian LU (2024) In Nature Reviews Molecular Cell Biology
Abstract

A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA degradation. These small RNAs have recently been implicated in an evolutionarily conserved repertoire of biological processes. In this Review, we discuss the biogenesis and molecular functions of tdRs in mammals, including tdR-mediated gene regulation in cell metabolism, immune responses, transgenerational inheritance, development and cancer. We also discuss the accumulation of tRNA-derived stress-induced RNAs as a distinct adaptive cellular response to pathophysiological conditions. Furthermore, we highlight new conceptual advances linking RNA modifications with tdR... (More)

A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA degradation. These small RNAs have recently been implicated in an evolutionarily conserved repertoire of biological processes. In this Review, we discuss the biogenesis and molecular functions of tdRs in mammals, including tdR-mediated gene regulation in cell metabolism, immune responses, transgenerational inheritance, development and cancer. We also discuss the accumulation of tRNA-derived stress-induced RNAs as a distinct adaptive cellular response to pathophysiological conditions. Furthermore, we highlight new conceptual advances linking RNA modifications with tdR activities and discuss challenges in studying tdR biology in health and disease.

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author
; ; and
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type
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publication status
epub
subject
in
Nature Reviews Molecular Cell Biology
publisher
Nature Publishing Group
external identifiers
  • pmid:38182846
  • scopus:85181467469
ISSN
1471-0072
DOI
10.1038/s41580-023-00690-z
language
English
LU publication?
yes
id
0788bf1d-1093-436e-84ad-0cc3059d78ae
date added to LUP
2024-02-06 13:51:00
date last changed
2024-04-22 20:55:26
@article{0788bf1d-1093-436e-84ad-0cc3059d78ae,
  abstract     = {{<p>A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA degradation. These small RNAs have recently been implicated in an evolutionarily conserved repertoire of biological processes. In this Review, we discuss the biogenesis and molecular functions of tdRs in mammals, including tdR-mediated gene regulation in cell metabolism, immune responses, transgenerational inheritance, development and cancer. We also discuss the accumulation of tRNA-derived stress-induced RNAs as a distinct adaptive cellular response to pathophysiological conditions. Furthermore, we highlight new conceptual advances linking RNA modifications with tdR activities and discuss challenges in studying tdR biology in health and disease.</p>}},
  author       = {{Muthukumar, Sowndarya and Li, Cai Tao and Liu, Ru Juan and Bellodi, Cristian}},
  issn         = {{1471-0072}},
  language     = {{eng}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Reviews Molecular Cell Biology}},
  title        = {{Roles and regulation of tRNA-derived small RNAs in animals}},
  url          = {{http://dx.doi.org/10.1038/s41580-023-00690-z}},
  doi          = {{10.1038/s41580-023-00690-z}},
  year         = {{2024}},
}