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Factors associated with meniscal body extrusion on knee MRI in overweight and obese women

Zhang, F. LU ; Bierma-Zeinstra, S M; Oei, E. H. G.; Turkiewicz, A. LU ; Englund, M. LU and Runhaar, J. (2017) In Osteoarthritis and Cartilage 25(5). p.694-699
Abstract

Objective: To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline data of the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study, Netherlands, comprising overweight or obese women aged 50-60 years, free of clinical knee OA. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1.5 T magnetic resonance imaging (MRI) of both knees. Using the mid-coronal MRI slice, one blinded observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. The association between baseline factors and meniscal... (More)

Objective: To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline data of the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study, Netherlands, comprising overweight or obese women aged 50-60 years, free of clinical knee OA. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1.5 T magnetic resonance imaging (MRI) of both knees. Using the mid-coronal MRI slice, one blinded observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. The association between baseline factors and meniscal extrusion, were analyzed with a random effects regression model. In addition, we used a fixed effect regression model for evaluation of knee-specific factors. Results: Mean age of the included women (n = 395) was 55.7 years and mean body mass index (BMI) 32.4 kg/m2. Of all knees, 23% had an absolute medial meniscus body extrusion ≥3.0 mm and 4% had lateral meniscus body extrusion ≥3.0 mm. In the multivariable model, the medial meniscus extrusion was increased by 0.44 mm (95% confidence interval [CI] 0.11, 0.77) when a medial meniscus tear was present, by 0.20 mm per 5 kg/m2 (95% CI 0.05, 0.35) increase in BMI and by 0.25 in the presence of mild knee symptoms (95% CI 0.05 to 0.44). Kellgren-Lawrence (KL) grade ≥1 and tibia width were associated with increased both medial and lateral extrusion. Conclusion: In women, ipsilateral meniscus tear and high BMI are factors associated with medial meniscus body extrusion.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Knee, Magnetic resonance imaging, Meniscus, Osteoarthritis, Women
in
Osteoarthritis and Cartilage
volume
25
issue
5
pages
694 - 699
publisher
Elsevier
external identifiers
  • scopus:85011003068
  • wos:000401095500011
ISSN
1063-4584
DOI
10.1016/j.joca.2016.12.001
language
English
LU publication?
yes
id
07b77630-c8e3-45b1-b751-0e8d15d7fb14
date added to LUP
2017-02-17 13:07:10
date last changed
2018-05-06 04:31:01
@article{07b77630-c8e3-45b1-b751-0e8d15d7fb14,
  abstract     = {<p>Objective: To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline data of the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study, Netherlands, comprising overweight or obese women aged 50-60 years, free of clinical knee OA. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1.5 T magnetic resonance imaging (MRI) of both knees. Using the mid-coronal MRI slice, one blinded observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. The association between baseline factors and meniscal extrusion, were analyzed with a random effects regression model. In addition, we used a fixed effect regression model for evaluation of knee-specific factors. Results: Mean age of the included women (n = 395) was 55.7 years and mean body mass index (BMI) 32.4 kg/m<sup>2</sup>. Of all knees, 23% had an absolute medial meniscus body extrusion ≥3.0 mm and 4% had lateral meniscus body extrusion ≥3.0 mm. In the multivariable model, the medial meniscus extrusion was increased by 0.44 mm (95% confidence interval [CI] 0.11, 0.77) when a medial meniscus tear was present, by 0.20 mm per 5 kg/m<sup>2</sup> (95% CI 0.05, 0.35) increase in BMI and by 0.25 in the presence of mild knee symptoms (95% CI 0.05 to 0.44). Kellgren-Lawrence (KL) grade ≥1 and tibia width were associated with increased both medial and lateral extrusion. Conclusion: In women, ipsilateral meniscus tear and high BMI are factors associated with medial meniscus body extrusion.</p>},
  author       = {Zhang, F. and Bierma-Zeinstra, S M and Oei, E. H. G. and Turkiewicz, A. and Englund, M. and Runhaar, J.},
  issn         = {1063-4584},
  keyword      = {Knee,Magnetic resonance imaging,Meniscus,Osteoarthritis,Women},
  language     = {eng},
  number       = {5},
  pages        = {694--699},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Factors associated with meniscal body extrusion on knee MRI in overweight and obese women},
  url          = {http://dx.doi.org/10.1016/j.joca.2016.12.001},
  volume       = {25},
  year         = {2017},
}