Impulsive-compulsive behaviours and striatal neuroactivity in mildly parkinsonian rats under D2/3 agonist and L-DOPA treatment
(2025) In npj Parkinson's Disease 11(1).- Abstract
Dopamine replacement therapy for Parkinson's disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining bilateral striatal injections of 6-hydroxydopamine. Daily treatment with ropinirole (2.5 mg/kg), L-DOPA (24.0 mg/kg), or their combination was given for six weeks while animals were examined using tests of compulsive checking and motor stereotypies not previously used in the ICB literature. Independently of L-DOPA cotreatment, ropinirole induced a stereotyped hyperactivity pattern, compulsive checking, and maladaptive choices in the rat version of the Iowa gambling task. Compared to both... (More)
Dopamine replacement therapy for Parkinson's disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining bilateral striatal injections of 6-hydroxydopamine. Daily treatment with ropinirole (2.5 mg/kg), L-DOPA (24.0 mg/kg), or their combination was given for six weeks while animals were examined using tests of compulsive checking and motor stereotypies not previously used in the ICB literature. Independently of L-DOPA cotreatment, ropinirole induced a stereotyped hyperactivity pattern, compulsive checking, and maladaptive choices in the rat version of the Iowa gambling task. Compared to both L-DOPA and vehicle, ropinirole elicited a distinct pattern of striatal neuroactivity, shifting the expression of a cellular activity marker from dorsolateral to centro-medial regions. Our results reveal quite distinct profiles of ICBs and striatal activation upon treatment with ropinirole or L-DOPA, providing clues of therapeutic relevance to Parkinson's ICBs.
(Less)
- author
- Wolfschlag, Mirjam
LU
; Espa, Elena
LU
; Skovgård, Katrine LU ; Halje, Pär LU
and Cenci, Maria Angela LU
- organization
-
- Psychiatry (Lund)
- Basal Ganglia Pathophysiology (research group)
- Clinical addiction research unit (research group)
- MultiPark: Multidisciplinary research focused on Parkinson's disease
- Integrative Neurophysiology (research group)
- eSSENCE: The e-Science Collaboration
- LU Profile Area: Natural and Artificial Cognition
- Neuronano Research Center (NRC) (research group)
- LU Profile Area: Proactive Ageing
- publishing date
- 2025-05-29
- type
- Contribution to journal
- publication status
- published
- subject
- in
- npj Parkinson's Disease
- volume
- 11
- issue
- 1
- article number
- 142
- publisher
- Springer Nature
- external identifiers
-
- scopus:105006927183
- pmid:40442152
- ISSN
- 2373-8057
- DOI
- 10.1038/s41531-025-00996-z
- language
- English
- LU publication?
- yes
- additional info
- © 2025. The Author(s).
- id
- 07e0a858-9f2a-491c-a893-ba81bc2442c2
- date added to LUP
- 2025-06-30 09:19:10
- date last changed
- 2025-07-01 04:02:32
@article{07e0a858-9f2a-491c-a893-ba81bc2442c2, abstract = {{<p>Dopamine replacement therapy for Parkinson's disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining bilateral striatal injections of 6-hydroxydopamine. Daily treatment with ropinirole (2.5 mg/kg), L-DOPA (24.0 mg/kg), or their combination was given for six weeks while animals were examined using tests of compulsive checking and motor stereotypies not previously used in the ICB literature. Independently of L-DOPA cotreatment, ropinirole induced a stereotyped hyperactivity pattern, compulsive checking, and maladaptive choices in the rat version of the Iowa gambling task. Compared to both L-DOPA and vehicle, ropinirole elicited a distinct pattern of striatal neuroactivity, shifting the expression of a cellular activity marker from dorsolateral to centro-medial regions. Our results reveal quite distinct profiles of ICBs and striatal activation upon treatment with ropinirole or L-DOPA, providing clues of therapeutic relevance to Parkinson's ICBs.</p>}}, author = {{Wolfschlag, Mirjam and Espa, Elena and Skovgård, Katrine and Halje, Pär and Cenci, Maria Angela}}, issn = {{2373-8057}}, language = {{eng}}, month = {{05}}, number = {{1}}, publisher = {{Springer Nature}}, series = {{npj Parkinson's Disease}}, title = {{Impulsive-compulsive behaviours and striatal neuroactivity in mildly parkinsonian rats under D2/3 agonist and L-DOPA treatment}}, url = {{http://dx.doi.org/10.1038/s41531-025-00996-z}}, doi = {{10.1038/s41531-025-00996-z}}, volume = {{11}}, year = {{2025}}, }