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A new case of photoallergic contact dermatitis caused by benzophenones in magazine covers

Samaran, Quentin ; Raison-Peyron, Nadia ; Clark, Evangeline ; Svedman, Cecilia LU ; Dahlin, Jakob LU ; Dereure, Olivier ; Bruze, Magnus LU and Bourrain, Jean Luc (2022) In Contact Dermatitis 86(4). p.300-307
Abstract

Background: Allergic contact dermatitis (ACD) and photoallergic contact dermatitis (PACD) to benzophenone present in printing ink have been reported. However, precise chemical analyses and extended photo-patch tests have not been performed in these cases. Objectives: To determine which components present in a magazine cover are responsible for a patient's skin reaction, to determine the primary sensitizer, and precisely diagnose ACD and PACD. Methods: After initial photo-patch tests were performed on a patient with a history of reaction to magazine covers after sun exposure, gas chromatography–mass spectrometry and high-performance liquid chromatography analyses of the magazine covers, and additional photo-patch tests were performed.... (More)

Background: Allergic contact dermatitis (ACD) and photoallergic contact dermatitis (PACD) to benzophenone present in printing ink have been reported. However, precise chemical analyses and extended photo-patch tests have not been performed in these cases. Objectives: To determine which components present in a magazine cover are responsible for a patient's skin reaction, to determine the primary sensitizer, and precisely diagnose ACD and PACD. Methods: After initial photo-patch tests were performed on a patient with a history of reaction to magazine covers after sun exposure, gas chromatography–mass spectrometry and high-performance liquid chromatography analyses of the magazine covers, and additional photo-patch tests were performed. Results: The first photo-patch test results confirmed PACD to ketoprofen and fenofibrate and evoked PACD to the magazine covers. 4-methyl benzophenone (4-MBP) and 1-hydroxy-cyclohexyl-phenyl-ketone (1-HCPK) were found in the magazine cover. Additional photo-patch tests confirmed PACD to 1-HCPK and to benzophenone, and photo-aggravated ACD to 4-MBP. The primary sensitizer was ketoprofen. Conclusions: Benzophenones are present in a wide variety of products, without always being listed on the packaging. Patients previously sensitized to other ketones, such as ketoprofen, may react to benzophenones without being able to avoid contact with these molecules. New regulations may be needed for more efficient eviction advice.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
1-hydroxy-cyclohexyl-phenyl-ketone, 4-methyl benzophenone, CAS number 119-61-9, CAS number 134-84-9, CAS number 6197-30-4, ketoprofen, octocrylene, photoallergy, unsubstituted benzophenone
in
Contact Dermatitis
volume
86
issue
4
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:35089601
  • scopus:85124510760
ISSN
0105-1873
DOI
10.1111/cod.14057
language
English
LU publication?
yes
id
08037495-c345-454f-81be-b331e8a638bd
date added to LUP
2022-04-13 12:29:27
date last changed
2024-09-11 00:03:42
@article{08037495-c345-454f-81be-b331e8a638bd,
  abstract     = {{<p>Background: Allergic contact dermatitis (ACD) and photoallergic contact dermatitis (PACD) to benzophenone present in printing ink have been reported. However, precise chemical analyses and extended photo-patch tests have not been performed in these cases. Objectives: To determine which components present in a magazine cover are responsible for a patient's skin reaction, to determine the primary sensitizer, and precisely diagnose ACD and PACD. Methods: After initial photo-patch tests were performed on a patient with a history of reaction to magazine covers after sun exposure, gas chromatography–mass spectrometry and high-performance liquid chromatography analyses of the magazine covers, and additional photo-patch tests were performed. Results: The first photo-patch test results confirmed PACD to ketoprofen and fenofibrate and evoked PACD to the magazine covers. 4-methyl benzophenone (4-MBP) and 1-hydroxy-cyclohexyl-phenyl-ketone (1-HCPK) were found in the magazine cover. Additional photo-patch tests confirmed PACD to 1-HCPK and to benzophenone, and photo-aggravated ACD to 4-MBP. The primary sensitizer was ketoprofen. Conclusions: Benzophenones are present in a wide variety of products, without always being listed on the packaging. Patients previously sensitized to other ketones, such as ketoprofen, may react to benzophenones without being able to avoid contact with these molecules. New regulations may be needed for more efficient eviction advice.</p>}},
  author       = {{Samaran, Quentin and Raison-Peyron, Nadia and Clark, Evangeline and Svedman, Cecilia and Dahlin, Jakob and Dereure, Olivier and Bruze, Magnus and Bourrain, Jean Luc}},
  issn         = {{0105-1873}},
  keywords     = {{1-hydroxy-cyclohexyl-phenyl-ketone; 4-methyl benzophenone; CAS number 119-61-9; CAS number 134-84-9; CAS number 6197-30-4; ketoprofen; octocrylene; photoallergy; unsubstituted benzophenone}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{300--307}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{A new case of photoallergic contact dermatitis caused by benzophenones in magazine covers}},
  url          = {{http://dx.doi.org/10.1111/cod.14057}},
  doi          = {{10.1111/cod.14057}},
  volume       = {{86}},
  year         = {{2022}},
}