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Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) : A prospective birth cohort in northern Sweden

Barman, Malin ; Murray, Fiona ; Bernardi, Angelina I. ; Broberg, Karin LU orcid ; Bölte, Sven ; Hesselmar, Bill ; Jacobsson, Bo ; Jonsson, Karin ; Kippler, Maria and Rabe, Hardis , et al. (2018) In BMJ Open 8(10).
Abstract

Introduction Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of the prospective birth cohort, 'Nutritional impact on Immunological maturation during Childhood in relation to the Environment' (NICE). The primary aim of the NICE cohort is to clarify the effect of key environmental exposures - diet, microbes and environmental toxicants - during pregnancy and early childhood, on the maturation of the infant's... (More)

Introduction Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of the prospective birth cohort, 'Nutritional impact on Immunological maturation during Childhood in relation to the Environment' (NICE). The primary aim of the NICE cohort is to clarify the effect of key environmental exposures - diet, microbes and environmental toxicants - during pregnancy and early childhood, on the maturation of the infant's immune system, including initiation of sensitisation and allergy as well as some secondary outcomes: Infant growth, obesity, neurological development and oral health. Methods and analysis The NICE cohort will recruit about 650 families during mid-pregnancy. The principal inclusion criterion will be planned birth at the Sunderby Hospital in the north of Sweden, during 2015-2018. Questionnaires data and biological samples will be collected at 10 time-points, from pregnancy until the children reach 4 years of age. Samples will be collected primarily from mothers and children, and from fathers. Biological samples include blood, urine, placenta, breast milk, meconium, faeces, saliva and hair. Information regarding allergic heredity, diet, socioeconomic status, lifestyle including smoking, siblings, pet ownership, etc will be collected using questionnaires. Sensitisation to common allergens will be assessed by skin prick testing and allergic disease will be diagnosed by a paediatrician at 1 and 4 years of age. At 4 years of age, the children will also be examined regarding growth, neurobehavioural and neurophysiological status and oral health. Ethics and dissemination The NICE cohort has been approved by the Regional Ethical Review Board in Umeå, Sweden (2013/18-31M). Results will be disseminated through peer-reviewed journals and communicated on scientific conferences.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergy, birth cohort, immunology, microbiology, nutrition, toxicants
in
BMJ Open
volume
8
issue
10
article number
e022013
publisher
BMJ Publishing Group
external identifiers
  • scopus:85055073603
  • pmid:30344169
ISSN
2044-6055
DOI
10.1136/bmjopen-2018-022013
language
English
LU publication?
no
id
08142efd-5a6e-4ac2-8dfb-a85b8e3eb91c
date added to LUP
2019-02-14 12:09:25
date last changed
2024-06-12 07:49:10
@article{08142efd-5a6e-4ac2-8dfb-a85b8e3eb91c,
  abstract     = {{<p>Introduction Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of the prospective birth cohort, 'Nutritional impact on Immunological maturation during Childhood in relation to the Environment' (NICE). The primary aim of the NICE cohort is to clarify the effect of key environmental exposures - diet, microbes and environmental toxicants - during pregnancy and early childhood, on the maturation of the infant's immune system, including initiation of sensitisation and allergy as well as some secondary outcomes: Infant growth, obesity, neurological development and oral health. Methods and analysis The NICE cohort will recruit about 650 families during mid-pregnancy. The principal inclusion criterion will be planned birth at the Sunderby Hospital in the north of Sweden, during 2015-2018. Questionnaires data and biological samples will be collected at 10 time-points, from pregnancy until the children reach 4 years of age. Samples will be collected primarily from mothers and children, and from fathers. Biological samples include blood, urine, placenta, breast milk, meconium, faeces, saliva and hair. Information regarding allergic heredity, diet, socioeconomic status, lifestyle including smoking, siblings, pet ownership, etc will be collected using questionnaires. Sensitisation to common allergens will be assessed by skin prick testing and allergic disease will be diagnosed by a paediatrician at 1 and 4 years of age. At 4 years of age, the children will also be examined regarding growth, neurobehavioural and neurophysiological status and oral health. Ethics and dissemination The NICE cohort has been approved by the Regional Ethical Review Board in Umeå, Sweden (2013/18-31M). Results will be disseminated through peer-reviewed journals and communicated on scientific conferences.</p>}},
  author       = {{Barman, Malin and Murray, Fiona and Bernardi, Angelina I. and Broberg, Karin and Bölte, Sven and Hesselmar, Bill and Jacobsson, Bo and Jonsson, Karin and Kippler, Maria and Rabe, Hardis and Ross, Alastair B. and Sjöberg, Fei and Strömberg, Nicklas and Vahter, Marie and Wold, Agnes E. and Sandberg, Ann Sofie and Sandin, Anna}},
  issn         = {{2044-6055}},
  keywords     = {{allergy; birth cohort; immunology; microbiology; nutrition; toxicants}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) : A prospective birth cohort in northern Sweden}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2018-022013}},
  doi          = {{10.1136/bmjopen-2018-022013}},
  volume       = {{8}},
  year         = {{2018}},
}