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Cohesin in haematopoiesis and leukaemia

Galeev, Roman LU and Larsson, Jonas LU (2018) In Current Opinion in Hematology 25(4). p.259-265
Abstract

Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic modifications as well as the organization and architecture of chromatin has become increasingly recognized. In this review, we will focus on the role of the chromatin organizing protein complex cohesin in regulation of normal and malignant haematopoiesis. Recent findings Several functional studies in both mouse and human systems have implicated cohesin as a critical regulator of self-renewal and differentiation in... (More)

Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic modifications as well as the organization and architecture of chromatin has become increasingly recognized. In this review, we will focus on the role of the chromatin organizing protein complex cohesin in regulation of normal and malignant haematopoiesis. Recent findings Several functional studies in both mouse and human systems have implicated cohesin as a critical regulator of self-renewal and differentiation in HSCs. Together with the discovery of recurrent mutations of cohesin genes in myeloid malignancies, this points towards a direct role of perturbed cohesin function in leukemogenesis. Summary The work reviewed here provides new insights about the role of the cohesin complex and chromatin architecture in normal and malignant HSCs, and indicates how cohesin may be specifically targeted for therapeutic benefit in the future.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chromosomal Architecture, Cohesin, Haematopoiesis, Leukaemia, Stem Cells
in
Current Opinion in Hematology
volume
25
issue
4
pages
7 pages
publisher
Lippincott Williams and Wilkins Ltd.
external identifiers
  • scopus:85050221218
ISSN
1065-6251
DOI
10.1097/MOH.0000000000000431n
language
English
LU publication?
yes
id
082278f3-5d30-4e8c-910b-06682468bf06
date added to LUP
2018-09-03 15:56:57
date last changed
2019-02-20 11:25:38
@article{082278f3-5d30-4e8c-910b-06682468bf06,
  abstract     = {<p>Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic modifications as well as the organization and architecture of chromatin has become increasingly recognized. In this review, we will focus on the role of the chromatin organizing protein complex cohesin in regulation of normal and malignant haematopoiesis. Recent findings Several functional studies in both mouse and human systems have implicated cohesin as a critical regulator of self-renewal and differentiation in HSCs. Together with the discovery of recurrent mutations of cohesin genes in myeloid malignancies, this points towards a direct role of perturbed cohesin function in leukemogenesis. Summary The work reviewed here provides new insights about the role of the cohesin complex and chromatin architecture in normal and malignant HSCs, and indicates how cohesin may be specifically targeted for therapeutic benefit in the future.</p>},
  author       = {Galeev, Roman and Larsson, Jonas},
  issn         = {1065-6251},
  keyword      = {Chromosomal Architecture,Cohesin,Haematopoiesis,Leukaemia,Stem Cells},
  language     = {eng},
  number       = {4},
  pages        = {259--265},
  publisher    = {Lippincott Williams and Wilkins Ltd.},
  series       = {Current Opinion in Hematology},
  title        = {Cohesin in haematopoiesis and leukaemia},
  url          = {http://dx.doi.org/10.1097/MOH.0000000000000431n},
  volume       = {25},
  year         = {2018},
}