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Nanoassemblies from vitamin C derivatives

Lo Nostro, P. ; Ambrosi, M. ; Fratini, E. ; Ridi, F. ; Carretti, E. ; Lagi, M. ; Alfredsson, V. LU ; Ninham, B. W. and Baglioni, P. (2007) 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 2. p.9-12
Abstract

Vitamin C is one of the most effective natural antioxidants. However, due to its poor solubility in non-aqueous environments, its use is restricted to water-based systems. In order to extend its advantages to lipophilic media, vitamin C must be converted into amphiphilic derivatives. Two new vitamin C-based surfactants were synthesized: a bolaform derivative (1,12-diascorbyl dodecanedioate, BOLA12), and a double chain product (2-octyl-dodecanoyl6-0- ascorbic acid, 8ASC10). Once dispersed in water above 0.5% w/w, BOLA12 forms hollow nanotubes that transform into clear micellar solutions on heating. 8ASC10 is poorly soluble in aqueous media, but it dissolves easily in cyclohexane where it forms true organogels. Cryo-TEM, XRD, SAXS,... (More)

Vitamin C is one of the most effective natural antioxidants. However, due to its poor solubility in non-aqueous environments, its use is restricted to water-based systems. In order to extend its advantages to lipophilic media, vitamin C must be converted into amphiphilic derivatives. Two new vitamin C-based surfactants were synthesized: a bolaform derivative (1,12-diascorbyl dodecanedioate, BOLA12), and a double chain product (2-octyl-dodecanoyl6-0- ascorbic acid, 8ASC10). Once dispersed in water above 0.5% w/w, BOLA12 forms hollow nanotubes that transform into clear micellar solutions on heating. 8ASC10 is poorly soluble in aqueous media, but it dissolves easily in cyclohexane where it forms true organogels. Cryo-TEM, XRD, SAXS, conductivity, viscosity and DSC experiments were performed in order to study the aggregation properties and morphology of these nanoassemblies.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Antioxidant, Ascorbic acid, Nanoparticles, Organogel, Vitamin C
host publication
2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
volume
2
pages
4 pages
conference name
2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
conference location
Santa Clara, CA, United States
conference dates
2007-05-20 - 2007-05-24
external identifiers
  • scopus:34547973920
ISBN
9781420063424
9781420061833
language
English
LU publication?
yes
id
084fa301-c63e-47e7-9464-fb7176be2ca6
date added to LUP
2019-05-29 08:52:41
date last changed
2020-01-13 01:55:57
@inproceedings{084fa301-c63e-47e7-9464-fb7176be2ca6,
  abstract     = {<p>Vitamin C is one of the most effective natural antioxidants. However, due to its poor solubility in non-aqueous environments, its use is restricted to water-based systems. In order to extend its advantages to lipophilic media, vitamin C must be converted into amphiphilic derivatives. Two new vitamin C-based surfactants were synthesized: a bolaform derivative (1,12-diascorbyl dodecanedioate, BOLA12), and a double chain product (2-octyl-dodecanoyl6-0- ascorbic acid, 8ASC10). Once dispersed in water above 0.5% w/w, BOLA12 forms hollow nanotubes that transform into clear micellar solutions on heating. 8ASC10 is poorly soluble in aqueous media, but it dissolves easily in cyclohexane where it forms true organogels. Cryo-TEM, XRD, SAXS, conductivity, viscosity and DSC experiments were performed in order to study the aggregation properties and morphology of these nanoassemblies.</p>},
  author       = {Lo Nostro, P. and Ambrosi, M. and Fratini, E. and Ridi, F. and Carretti, E. and Lagi, M. and Alfredsson, V. and Ninham, B. W. and Baglioni, P.},
  booktitle    = {2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings},
  isbn         = {9781420063424},
  language     = {eng},
  month        = {08},
  pages        = {9--12},
  title        = {Nanoassemblies from vitamin C derivatives},
  volume       = {2},
  year         = {2007},
}