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Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)

Wilkinson, JD ; Shaw, S ; Andersen, KE ; Brandao, FM ; Bruynzeel, DP ; Bruze, Magnus LU ; Camarasa, JMG ; Diepgen, TL ; Ducombs, G and Frosch, PJ , et al. (2002) In Contact Dermatitis 46(4). p.207-210
Abstract
A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diazolidinyl urea, formaldehyde, imidazolidinyl urea, methyldibromoglutaronitrile, patch test sensitization, parabens, preservatives, quaternium-15, 5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one
in
Contact Dermatitis
volume
46
issue
4
pages
207 - 210
publisher
Wiley-Blackwell
external identifiers
  • wos:000176797000004
  • pmid:12081698
  • scopus:0036318486
ISSN
0105-1873
DOI
10.1034/j.1600-0536.2002.460404.x
language
English
LU publication?
yes
id
086c5ca1-f4db-4514-8663-0a70d958eac2 (old id 892992)
date added to LUP
2016-04-01 12:20:34
date last changed
2022-08-28 19:30:58
@article{086c5ca1-f4db-4514-8663-0a70d958eac2,
  abstract     = {{A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.}},
  author       = {{Wilkinson, JD and Shaw, S and Andersen, KE and Brandao, FM and Bruynzeel, DP and Bruze, Magnus and Camarasa, JMG and Diepgen, TL and Ducombs, G and Frosch, PJ and Goossens, A and Lachappelle, JM and Lahti, A and Menne, T and Seidenari, S and Tosti, A and Wahlberg, JE}},
  issn         = {{0105-1873}},
  keywords     = {{diazolidinyl urea; formaldehyde; imidazolidinyl urea; methyldibromoglutaronitrile; patch test sensitization; parabens; preservatives; quaternium-15; 5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{207--210}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)}},
  url          = {{http://dx.doi.org/10.1034/j.1600-0536.2002.460404.x}},
  doi          = {{10.1034/j.1600-0536.2002.460404.x}},
  volume       = {{46}},
  year         = {{2002}},
}