Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)
(2002) In Contact Dermatitis 46(4). p.207-210- Abstract
- A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/892992
- author
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diazolidinyl urea, formaldehyde, imidazolidinyl urea, methyldibromoglutaronitrile, patch test sensitization, parabens, preservatives, quaternium-15, 5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one
- in
- Contact Dermatitis
- volume
- 46
- issue
- 4
- pages
- 207 - 210
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000176797000004
- pmid:12081698
- scopus:0036318486
- ISSN
- 0105-1873
- DOI
- 10.1034/j.1600-0536.2002.460404.x
- language
- English
- LU publication?
- yes
- id
- 086c5ca1-f4db-4514-8663-0a70d958eac2 (old id 892992)
- date added to LUP
- 2016-04-01 12:20:34
- date last changed
- 2022-08-28 19:30:58
@article{086c5ca1-f4db-4514-8663-0a70d958eac2, abstract = {{A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.}}, author = {{Wilkinson, JD and Shaw, S and Andersen, KE and Brandao, FM and Bruynzeel, DP and Bruze, Magnus and Camarasa, JMG and Diepgen, TL and Ducombs, G and Frosch, PJ and Goossens, A and Lachappelle, JM and Lahti, A and Menne, T and Seidenari, S and Tosti, A and Wahlberg, JE}}, issn = {{0105-1873}}, keywords = {{diazolidinyl urea; formaldehyde; imidazolidinyl urea; methyldibromoglutaronitrile; patch test sensitization; parabens; preservatives; quaternium-15; 5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one}}, language = {{eng}}, number = {{4}}, pages = {{207--210}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)}}, url = {{http://dx.doi.org/10.1034/j.1600-0536.2002.460404.x}}, doi = {{10.1034/j.1600-0536.2002.460404.x}}, volume = {{46}}, year = {{2002}}, }