Postoperative pain treatment after spinal fusion surgery : A systematic review with meta-analyses and trial sequential analyses
Geisler, Anja LU
; Zachodnik, Josephine
LU
; Køppen, Kasper
; Chakari, Rehan
and Bech-Azeddine, Rachid
(2022)
In Pain Reports
7(3).
p.1005-1005
- Abstract
Patients undergoing spinal surgery are at high risk of acute and persistent postoperative pain. Therefore, adequate pain relief is crucial. This systematic review aimed to provide answers about best-proven postoperative analgesic treatment for patients undergoing lumbar 1- or 2-level fusions for degenerative spine diseases. We performed a search in PubMed, Embase, and The Cochrane Library for randomized controlled trials. The primary outcome was opioid consumption after 24 hours postoperatively. We performed meta-analyses, trial sequential analyses, and Grading of Recommendations assessment to accommodate systematic errors. Forty-four randomized controlled trials were included with 2983 participants. Five subgroups emerged: nonsteroidal... (More)
Patients undergoing spinal surgery are at high risk of acute and persistent postoperative pain. Therefore, adequate pain relief is crucial. This systematic review aimed to provide answers about best-proven postoperative analgesic treatment for patients undergoing lumbar 1- or 2-level fusions for degenerative spine diseases. We performed a search in PubMed, Embase, and The Cochrane Library for randomized controlled trials. The primary outcome was opioid consumption after 24 hours postoperatively. We performed meta-analyses, trial sequential analyses, and Grading of Recommendations assessment to accommodate systematic errors. Forty-four randomized controlled trials were included with 2983 participants. Five subgroups emerged: nonsteroidal anti-inflammatory drugs (NSAIDs), epidural, ketamine, local infiltration analgesia, and intrathecal morphine. The results showed a significant reduction in opioid consumption for treatment with NSAID (P < 0.0008) and epidural (P < 0.0006) (predefined minimal clinical relevance of 10 mg). Concerning secondary outcomes, significant reductions in pain scores were detected after 6 hours at rest (NSAID [P < 0.0001] and intrathecal morphine [P < 0.0001]), 6 hours during mobilization (intrathecal morphine [P = 0.003]), 24 hours at rest (epidural [P < 0.00001] and ketamine [P < 0.00001]), and 24 hours during mobilization (intrathecal morphine [P = 0.03]). The effect of wound infiltration was nonsignificant. The quality of evidence was low to very low for most trials. The results from this systematic review showed that some analgesic interventions have the capability to reduce opioid consumption compared with control groups. However, because of the high risk of bias and low evidence, it was impossible to recommend a "gold standard" for the analgesic treatment after 1- or 2-level spinal fusion surgery.
(Less)
- author
- Geisler, Anja
LU
; Zachodnik, Josephine
LU
; Køppen, Kasper
; Chakari, Rehan
and Bech-Azeddine, Rachid
- organization
- publishing date
- 2022-05-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Analgesics, Pain, Pain treatment, Spinal fusion
- in
- Pain Reports
- volume
- 7
- issue
- 3
- pages
- 1005 - 1005
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85132678964
- pmid:35505790
- ISSN
- 2471-2531
- DOI
- 10.1097/PR9.0000000000001005
- language
- English
- LU publication?
- yes
- id
- 086e4428-79fa-40e2-9035-e380213c691f
- date added to LUP
- 2022-09-13 11:24:24
- date last changed
- 2024-06-13 19:19:43
@article{086e4428-79fa-40e2-9035-e380213c691f,
abstract = {{<p>Patients undergoing spinal surgery are at high risk of acute and persistent postoperative pain. Therefore, adequate pain relief is crucial. This systematic review aimed to provide answers about best-proven postoperative analgesic treatment for patients undergoing lumbar 1- or 2-level fusions for degenerative spine diseases. We performed a search in PubMed, Embase, and The Cochrane Library for randomized controlled trials. The primary outcome was opioid consumption after 24 hours postoperatively. We performed meta-analyses, trial sequential analyses, and Grading of Recommendations assessment to accommodate systematic errors. Forty-four randomized controlled trials were included with 2983 participants. Five subgroups emerged: nonsteroidal anti-inflammatory drugs (NSAIDs), epidural, ketamine, local infiltration analgesia, and intrathecal morphine. The results showed a significant reduction in opioid consumption for treatment with NSAID (P < 0.0008) and epidural (P < 0.0006) (predefined minimal clinical relevance of 10 mg). Concerning secondary outcomes, significant reductions in pain scores were detected after 6 hours at rest (NSAID [P < 0.0001] and intrathecal morphine [P < 0.0001]), 6 hours during mobilization (intrathecal morphine [P = 0.003]), 24 hours at rest (epidural [P < 0.00001] and ketamine [P < 0.00001]), and 24 hours during mobilization (intrathecal morphine [P = 0.03]). The effect of wound infiltration was nonsignificant. The quality of evidence was low to very low for most trials. The results from this systematic review showed that some analgesic interventions have the capability to reduce opioid consumption compared with control groups. However, because of the high risk of bias and low evidence, it was impossible to recommend a "gold standard" for the analgesic treatment after 1- or 2-level spinal fusion surgery.</p>}},
author = {{Geisler, Anja and Zachodnik, Josephine and Køppen, Kasper and Chakari, Rehan and Bech-Azeddine, Rachid}},
issn = {{2471-2531}},
keywords = {{Analgesics; Pain; Pain treatment; Spinal fusion}},
language = {{eng}},
month = {{05}},
number = {{3}},
pages = {{1005--1005}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Pain Reports}},
title = {{Postoperative pain treatment after spinal fusion surgery : A systematic review with meta-analyses and trial sequential analyses}},
url = {{http://dx.doi.org/10.1097/PR9.0000000000001005}},
doi = {{10.1097/PR9.0000000000001005}},
volume = {{7}},
year = {{2022}},
}