The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
(2012) In Nature Immunology 13(4). p.412-419- Abstract
- The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate... (More)
- The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus. (Less)
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https://lup.lub.lu.se/record/2366718
- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Immunology
- volume
- 13
- issue
- 4
- pages
- 412 - 419
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000301886800016
- pmid:22344248
- scopus:84862776978
- pmid:22344248
- ISSN
- 1529-2908
- DOI
- 10.1038/ni.2255
- language
- English
- LU publication?
- yes
- id
- 08871447-352b-447c-98b7-82f1586caa18 (old id 2366718)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22344248?dopt=Abstract
- date added to LUP
- 2016-04-04 09:26:31
- date last changed
- 2022-08-23 07:05:08
@article{08871447-352b-447c-98b7-82f1586caa18,
abstract = {{The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus.}},
author = {{Luc, Sidinh and Luis, Tiago C and Boukarabila, Hanane and Macaulay, Iain C and Buza-Vidas, Natalija and Bouriez-Jones, Tiphaine and Lutteropp, Michael and Woll, Petter S and Loughran, Stephen J and Mead, Adam J and Hultquist, Anne and Brown, John and Mizukami, Takuo and Matsuoka, Sahoko and Ferry, Helen and Anderson, Kristina and Duarte, Sara and Atkinson, Deborah and Soneji, Shamit and Domanski, Aniela and Farley, Alison and Sanjuan-Pla, Alejandra and Carella, Cintia and Patient, Roger and de Bruijn, Marella and Enver, Tariq and Nerlov, Claus and Blackburn, Clare and Godin, Isabelle and Jacobsen, Sten Eirik W}},
issn = {{1529-2908}},
language = {{eng}},
number = {{4}},
pages = {{412--419}},
publisher = {{Nature Publishing Group}},
series = {{Nature Immunology}},
title = {{The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.}},
url = {{http://dx.doi.org/10.1038/ni.2255}},
doi = {{10.1038/ni.2255}},
volume = {{13}},
year = {{2012}},
}