Reactions to awareness of activated protein C resistance carriership: a descriptive study of 270 women.
(2003) In Acta Obstetricia et Gynecologica Scandinavica 82(5). p.467-470- Abstract
- Background. Around 25 million Caucasian women are carriers of the FV Leiden mutation that causes activated protein C (APC) resistance. This is a heritable condition with a lifelong increased risk of venous thromboembolism. We performed this study to investigate women's reactions to their awareness of being APC-resistant and the consequences of this awareness.
Methods. All APC-resistant women (n = 270) included in a prior study on APC resistance and pregnancy (n = 2480) were invited by written questionnaire to describe their reactions to having APC resistance, how this had changed their lives, and how they experienced our information. Answers were obtained from 215 of the 270 women (80%).
Results. More... (More) - Background. Around 25 million Caucasian women are carriers of the FV Leiden mutation that causes activated protein C (APC) resistance. This is a heritable condition with a lifelong increased risk of venous thromboembolism. We performed this study to investigate women's reactions to their awareness of being APC-resistant and the consequences of this awareness.
Methods. All APC-resistant women (n = 270) included in a prior study on APC resistance and pregnancy (n = 2480) were invited by written questionnaire to describe their reactions to having APC resistance, how this had changed their lives, and how they experienced our information. Answers were obtained from 215 of the 270 women (80%).
Results. More than 94% of the APC-resistant women were satisfied with knowing themselves to be APC-resistant and pleased that they had enrolled in the study. Of the women on combined oral contraceptives (COC), 84% changed their method of contraception, but 16% continued on COC. One-third of the women reported becoming more worried or afraid of getting pregnant again as a result of their awareness of being APC-resistant. The proportion of women who sought legal abortions during a 2-year period after receiving this information was similar in both subgroups: 4.4% (12/270) vs. 4.3% (94/2210), p = 0.9.
Conclusions. We conclude that most APC-resistant women were pleased to learn of their APC resistance status, that there was not an increased incidence of legal abortions, but almost one-third reported being more worried or afraid of getting pregnant again. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/113962
- author
- Lindqvist, Pelle LU and Dahlbäck, Björn LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 82
- issue
- 5
- pages
- 467 - 470
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:12752078
- wos:000182832900010
- scopus:0037901100
- ISSN
- 1600-0412
- DOI
- 10.1034/j.1600-0412.2003.00118.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Chemistry, Malmö (013016000), Obstetrics and Gynaecology (013242700), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 0890be05-4773-4bb8-af4a-539307c43ea1 (old id 113962)
- date added to LUP
- 2016-04-01 15:47:56
- date last changed
- 2022-01-28 07:11:22
@article{0890be05-4773-4bb8-af4a-539307c43ea1,
abstract = {{Background. Around 25 million Caucasian women are carriers of the FV Leiden mutation that causes activated protein C (APC) resistance. This is a heritable condition with a lifelong increased risk of venous thromboembolism. We performed this study to investigate women's reactions to their awareness of being APC-resistant and the consequences of this awareness.<br/><br>
<br/><br>
Methods. All APC-resistant women (n = 270) included in a prior study on APC resistance and pregnancy (n = 2480) were invited by written questionnaire to describe their reactions to having APC resistance, how this had changed their lives, and how they experienced our information. Answers were obtained from 215 of the 270 women (80%).<br/><br>
<br/><br>
Results. More than 94% of the APC-resistant women were satisfied with knowing themselves to be APC-resistant and pleased that they had enrolled in the study. Of the women on combined oral contraceptives (COC), 84% changed their method of contraception, but 16% continued on COC. One-third of the women reported becoming more worried or afraid of getting pregnant again as a result of their awareness of being APC-resistant. The proportion of women who sought legal abortions during a 2-year period after receiving this information was similar in both subgroups: 4.4% (12/270) vs. 4.3% (94/2210), p = 0.9.<br/><br>
<br/><br>
Conclusions. We conclude that most APC-resistant women were pleased to learn of their APC resistance status, that there was not an increased incidence of legal abortions, but almost one-third reported being more worried or afraid of getting pregnant again.}},
author = {{Lindqvist, Pelle and Dahlbäck, Björn}},
issn = {{1600-0412}},
language = {{eng}},
number = {{5}},
pages = {{467--470}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Obstetricia et Gynecologica Scandinavica}},
title = {{Reactions to awareness of activated protein C resistance carriership: a descriptive study of 270 women.}},
url = {{https://lup.lub.lu.se/search/files/4475454/623772.pdf}},
doi = {{10.1034/j.1600-0412.2003.00118.x}},
volume = {{82}},
year = {{2003}},
}